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• W3118377679 abstract "Alcoholic steatohepatitis (ASH) is a complex multifactorial disease that can lead to liver fibrosis and cirrhosis if not treated promptly. Alcohol‑induced oxidative stress and inflammation are the main factors that cause steatohepatitis and liver injury; however, probiotic bacteria in the gastrointestinal tract have been revealed to regulate immune responses and reduce oxidative stress, suggesting that functional probiotics could help to prevent ASH and liver injury. Despite numerous reports on the interactions between ASH and probiotics, the mechanisms underlying probiotic‑mediated liver protection remain unknown. Therefore, the aim of the present study was to screen probiotics with high antioxidant capacity and investigate the ability of different probiotic combinations to reduce alcoholic liver disease (ALD) in a mouse model. It was identified that <em>Lactobacillus plantarum</em> (TSP05), <em>Lactobacillus fermentum</em> (TSF331) and <em>Lactobacillus reuteri</em> (TSR332) neutralized free radicals and displayed high antioxidant activity <em>in vitro</em>. In addition, these three functional probiotic strains protected mice from alcohol‑induced liver injury <em>in vivo</em>. Mice treated with the probiotics demonstrated significantly lower alanine aminotransferase, aspartate aminotransferase and triglyceride levels, which were associated with the downregulation of the proinflammatory cytokines TNF‑α and IL‑6. Furthermore, probiotic treatment upregulated glutathione and glutathione peroxidase activity, which are bioindicators of oxidative stress in the liver. Collectively, the present results indicated that <em>Lactobacillus</em> strains TSP05, TSF331 and TSR332 reduced oxidative stress and inflammatory responses, thus preventing ASH development and liver injury." @default.
• W3118377679 created "2021-01-18" @default.
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• W3118377679 date "2021-01-07" @default.
• W3118377679 modified "2023-09-30" @default.
• W3118377679 title "<i>Lactobacillus</i> spp. reduces ethanol‑induced liver oxidative stress and inflammation in a mouse model of alcoholic steatohepatitis" @default.
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• W3118377679 doi "https://doi.org/10.3892/etm.2021.9619" @default.
• W3118377679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7812587" @default.
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• W3118377679 hasPublicationYear "2021" @default.
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