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• W3118382495 abstract "Adjuvant chemotherapy for high-risk Stage II colorectal cancer (CRC) is weakly recommended; however, no consensus exists on high-risk definition. Prognostic biomarker identification is important for selecting patients with poor prognosis who may benefit from adjuvant chemotherapy.Using Microarray data analyses, ELF3 was identified as a candidate gene highly expressed in Stage II CRC with distant recurrences. ELF3 mRNA expression in 168 Stage II CRC patients was subjected to quantitative RT-PCR analysis and ELF3 protein expression in 185 patients was quantified by immunohistochemical analysis. The relationship between mRNA and protein expression levels and patient characteristics were also investigated.The overall recurrence rate and relapse-free survival were significantly poorer in the ELF3 high-expression than the low-expression group at the mRNA and protein levels. High ELF3 mRNA and protein expression levels were independent poor prognostic factors.High ELF3 expression was associated with recurrence of Stage II." @default.
• W3118382495 created "2021-01-18" @default.
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• W3118382495 date "2021-01-01" @default.
• W3118382495 modified "2023-10-16" @default.
• W3118382495 title "ELF3 Overexpression as Prognostic Biomarker for Recurrence of Stage II Colorectal Cancer" @default.
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• W3118382495 doi "https://doi.org/10.21873/invivo.12248" @default.
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