Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118390988> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3118390988 endingPage "41" @default.
- W3118390988 startingPage "37" @default.
- W3118390988 abstract "Currently, brucellosis is a reemerged zoonotic infectious disease with an increased incidence in recent years. A simple, rapid and sensitive method for diagnosing brucellosis can help to reduce medical burden and economic loss. Previously, a multiple epitope recombinant protein was constructed based on linear B-cell epitope prediction tools. In this study, the recombinant protein was used as an antigen to study the immune response produced by immunized mice, and goat serum was used to verify its diagnostic accuracy. The production of antibodies was successfully induced in the vaccinated mice. Flow cytometric analysis revealed that the percentage of CD4+, CD8+ and the CD4+/CD8+ ratios were increased by T cell subsets in mouse splenocytes, indicating that the recombinant protein induced a strong immune response had strong immunoreactivity. Using indirect ELISA, the recombinant protein correctly diagnosed positive and negative brucellosis samples. Compared with the whole bacterial antigen, the recombinant protein had a weaker sensitivity but a stronger specificity. Animal experiments showed that the recombinant protein had good antigenicity, and indirect ELISA indicates that it can be used as an antigen to diagnose brucellosis. Therefore, the recombinant protein is a potential candidate antigen for brucellosis vaccine development and serological diagnosis." @default.
- W3118390988 created "2021-01-18" @default.
- W3118390988 creator A5011320158 @default.
- W3118390988 creator A5041666851 @default.
- W3118390988 creator A5069614761 @default.
- W3118390988 creator A5077810228 @default.
- W3118390988 creator A5074324668 @default.
- W3118390988 date "2021-02-01" @default.
- W3118390988 modified "2023-10-09" @default.
- W3118390988 title "Study on immunogenicity and antigenicity of a novel brucella multiepitope recombined protein" @default.
- W3118390988 cites W1884755575 @default.
- W3118390988 cites W1981318764 @default.
- W3118390988 cites W1990748933 @default.
- W3118390988 cites W2004964780 @default.
- W3118390988 cites W2022434858 @default.
- W3118390988 cites W2025291938 @default.
- W3118390988 cites W2063996876 @default.
- W3118390988 cites W2105324605 @default.
- W3118390988 cites W2108944515 @default.
- W3118390988 cites W2152433395 @default.
- W3118390988 cites W224130115 @default.
- W3118390988 cites W2301640802 @default.
- W3118390988 cites W2395403452 @default.
- W3118390988 cites W2586589562 @default.
- W3118390988 cites W2588890568 @default.
- W3118390988 cites W2605242490 @default.
- W3118390988 cites W2766298563 @default.
- W3118390988 cites W2796592868 @default.
- W3118390988 doi "https://doi.org/10.1016/j.bbrc.2020.12.098" @default.
- W3118390988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33429198" @default.
- W3118390988 hasPublicationYear "2021" @default.
- W3118390988 type Work @default.
- W3118390988 sameAs 3118390988 @default.
- W3118390988 citedByCount "8" @default.
- W3118390988 countsByYear W31183909882021 @default.
- W3118390988 countsByYear W31183909882022 @default.
- W3118390988 countsByYear W31183909882023 @default.
- W3118390988 crossrefType "journal-article" @default.
- W3118390988 hasAuthorship W3118390988A5011320158 @default.
- W3118390988 hasAuthorship W3118390988A5041666851 @default.
- W3118390988 hasAuthorship W3118390988A5069614761 @default.
- W3118390988 hasAuthorship W3118390988A5074324668 @default.
- W3118390988 hasAuthorship W3118390988A5077810228 @default.
- W3118390988 hasConcept C104317684 @default.
- W3118390988 hasConcept C147483822 @default.
- W3118390988 hasConcept C159047783 @default.
- W3118390988 hasConcept C159654299 @default.
- W3118390988 hasConcept C195616568 @default.
- W3118390988 hasConcept C203014093 @default.
- W3118390988 hasConcept C2779026604 @default.
- W3118390988 hasConcept C2780767784 @default.
- W3118390988 hasConcept C2780868878 @default.
- W3118390988 hasConcept C2781429187 @default.
- W3118390988 hasConcept C40767141 @default.
- W3118390988 hasConcept C45189115 @default.
- W3118390988 hasConcept C55493867 @default.
- W3118390988 hasConcept C86803240 @default.
- W3118390988 hasConcept C8891405 @default.
- W3118390988 hasConceptScore W3118390988C104317684 @default.
- W3118390988 hasConceptScore W3118390988C147483822 @default.
- W3118390988 hasConceptScore W3118390988C159047783 @default.
- W3118390988 hasConceptScore W3118390988C159654299 @default.
- W3118390988 hasConceptScore W3118390988C195616568 @default.
- W3118390988 hasConceptScore W3118390988C203014093 @default.
- W3118390988 hasConceptScore W3118390988C2779026604 @default.
- W3118390988 hasConceptScore W3118390988C2780767784 @default.
- W3118390988 hasConceptScore W3118390988C2780868878 @default.
- W3118390988 hasConceptScore W3118390988C2781429187 @default.
- W3118390988 hasConceptScore W3118390988C40767141 @default.
- W3118390988 hasConceptScore W3118390988C45189115 @default.
- W3118390988 hasConceptScore W3118390988C55493867 @default.
- W3118390988 hasConceptScore W3118390988C86803240 @default.
- W3118390988 hasConceptScore W3118390988C8891405 @default.
- W3118390988 hasFunder F4320321001 @default.
- W3118390988 hasLocation W31183909881 @default.
- W3118390988 hasOpenAccess W3118390988 @default.
- W3118390988 hasPrimaryLocation W31183909881 @default.
- W3118390988 hasRelatedWork W1974701537 @default.
- W3118390988 hasRelatedWork W2013855543 @default.
- W3118390988 hasRelatedWork W2072925709 @default.
- W3118390988 hasRelatedWork W2120682552 @default.
- W3118390988 hasRelatedWork W2365265574 @default.
- W3118390988 hasRelatedWork W2387854940 @default.
- W3118390988 hasRelatedWork W2617717260 @default.
- W3118390988 hasRelatedWork W2841858102 @default.
- W3118390988 hasRelatedWork W3113090860 @default.
- W3118390988 hasRelatedWork W4210976760 @default.
- W3118390988 hasVolume "540" @default.
- W3118390988 isParatext "false" @default.
- W3118390988 isRetracted "false" @default.
- W3118390988 magId "3118390988" @default.
- W3118390988 workType "article" @default.