FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118406134> ?p ?o ?g. }

• W3118406134 abstract "Abstract Alcohol use disorders are associated with altered stress responses, but the impact of stress or stress hormones on alcohol-associated tissue injury remain unknown. We evaluated the effects of chronic restraint stress on alcohol-induced gut barrier dysfunction and liver damage in mice. To determine whether corticosterone is the stress hormone associated with the stress-induced effects, we evaluated the effect of chronic corticosterone treatment on alcoholic tissue injury at the Gut-Liver-Brain (GLB) axis. Chronic restraint stress synergized alcohol-induced epithelial tight junction disruption and mucosal barrier dysfunction in the mouse intestine. These effects of stress on the gut were reproduced by corticosterone treatment. Corticosterone synergized alcohol-induced expression of inflammatory cytokines and chemokines in the colonic mucosa, and it potentiated the alcohol-induced endotoxemia and systemic inflammation. Corticosterone also potentiated alcohol-induced liver damage and neuroinflammation. Metagenomic analyses of 16S RNA from fecal samples indicated that corticosterone modulates alcohol-induced changes in the diversity and abundance of gut microbiota. In Caco-2 cell monolayers, corticosterone dose-dependently potentiated ethanol and acetaldehyde-induced tight junction disruption and barrier dysfunction. These data indicate that chronic stress and corticosterone exacerbate alcohol-induced mucosal barrier dysfunction, endotoxemia, and systemic alcohol responses. Corticosterone-mediated promotion of alcohol-induced intestinal epithelial barrier dysfunction and modulation of gut microbiota may play a crucial role in the mechanism of stress-induced promotion of alcohol-associated tissue injury at the GLB axis." @default.
• W3118406134 created "2021-01-18" @default.
• W3118406134 creator A5001935220 @default.
• W3118406134 creator A5014897747 @default.
• W3118406134 creator A5030069750 @default.
• W3118406134 creator A5043439845 @default.
• W3118406134 creator A5048295218 @default.
• W3118406134 creator A5067873267 @default.
• W3118406134 creator A5085571191 @default.
• W3118406134 date "2021-01-12" @default.
• W3118406134 modified "2023-10-14" @default.
• W3118406134 title "Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis" @default.
• W3118406134 cites W1909001249 @default.
• W3118406134 cites W1955956111 @default.
• W3118406134 cites W1966100684 @default.
• W3118406134 cites W1967075670 @default.
• W3118406134 cites W1988232165 @default.
• W3118406134 cites W1990652217 @default.
• W3118406134 cites W2001339909 @default.
• W3118406134 cites W2001368120 @default.
• W3118406134 cites W2001807421 @default.
• W3118406134 cites W2009962309 @default.
• W3118406134 cites W2014895573 @default.
• W3118406134 cites W2021067562 @default.
• W3118406134 cites W2023393695 @default.
• W3118406134 cites W2025175138 @default.
• W3118406134 cites W2029206647 @default.
• W3118406134 cites W2033574728 @default.
• W3118406134 cites W2052353081 @default.
• W3118406134 cites W2055615060 @default.
• W3118406134 cites W2056700437 @default.
• W3118406134 cites W2057607705 @default.
• W3118406134 cites W2062679887 @default.
• W3118406134 cites W2072970694 @default.
• W3118406134 cites W2074802748 @default.
• W3118406134 cites W2075627423 @default.
• W3118406134 cites W2075678565 @default.
• W3118406134 cites W2080414792 @default.
• W3118406134 cites W2095622480 @default.
• W3118406134 cites W2101976554 @default.
• W3118406134 cites W2107974372 @default.
• W3118406134 cites W2109758577 @default.
• W3118406134 cites W2109887747 @default.
• W3118406134 cites W2116613162 @default.
• W3118406134 cites W2117427121 @default.
• W3118406134 cites W2133856765 @default.
• W3118406134 cites W2137195441 @default.
• W3118406134 cites W2144101679 @default.
• W3118406134 cites W2144164560 @default.
• W3118406134 cites W2144241574 @default.
• W3118406134 cites W2151528895 @default.
• W3118406134 cites W2154267400 @default.
• W3118406134 cites W2158056092 @default.
• W3118406134 cites W2158714604 @default.
• W3118406134 cites W2159121293 @default.
• W3118406134 cites W2165287767 @default.
• W3118406134 cites W2165763519 @default.
• W3118406134 cites W2335154487 @default.
• W3118406134 cites W2346126968 @default.
• W3118406134 cites W2346182089 @default.
• W3118406134 cites W2562459144 @default.
• W3118406134 cites W2567810317 @default.
• W3118406134 cites W2597760243 @default.
• W3118406134 cites W2607482562 @default.
• W3118406134 cites W2734346863 @default.
• W3118406134 cites W2737435763 @default.
• W3118406134 cites W2740555439 @default.
• W3118406134 cites W2744370763 @default.
• W3118406134 cites W2767147988 @default.
• W3118406134 cites W2794786155 @default.
• W3118406134 cites W2800763374 @default.
• W3118406134 cites W2808957885 @default.
• W3118406134 cites W2809066811 @default.
• W3118406134 cites W2885163899 @default.
• W3118406134 cites W2891714351 @default.
• W3118406134 cites W2898382334 @default.
• W3118406134 cites W2899606608 @default.
• W3118406134 cites W2906203106 @default.
• W3118406134 cites W2910227631 @default.
• W3118406134 cites W2947532365 @default.
• W3118406134 cites W2968952134 @default.
• W3118406134 cites W2990614114 @default.
• W3118406134 cites W2998313718 @default.
• W3118406134 cites W3047844189 @default.
• W3118406134 cites W4245214185 @default.
• W3118406134 doi "https://doi.org/10.1038/s41598-020-80637-y" @default.
• W3118406134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7804442" @default.
• W3118406134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33436875" @default.
• W3118406134 hasPublicationYear "2021" @default.
• W3118406134 type Work @default.
• W3118406134 sameAs 3118406134 @default.
• W3118406134 citedByCount "32" @default.
• W3118406134 countsByYear W31184061342021 @default.
• W3118406134 countsByYear W31184061342022 @default.
• W3118406134 countsByYear W31184061342023 @default.
• W3118406134 crossrefType "journal-article" @default.
• W3118406134 hasAuthorship W3118406134A5001935220 @default.
• W3118406134 hasAuthorship W3118406134A5014897747 @default.
• W3118406134 hasAuthorship W3118406134A5030069750 @default.
• W3118406134 hasAuthorship W3118406134A5043439845 @default.

• next