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- W3118406422 abstract "Abstract Background Glioblastoma multiforme (GBM) is one of the most daunting issues to modern therapeutics, with a higher mortality rate post-diagnosis. Temozolomide (TMZ) is the only available treatment; however, the frequent resistance leaves the oncologists at a dead end. Therefore, new approaches to circumvent the GBM are highly desired. We have employed TiO 2 nanosticks loaded with TMZ as nanomedicine for TMZ-resistant GBM resection in this contribution. Results The ultrasonication triple-action effect could greatly facilitate tumor ablation by enhancing the TiO 2 nanosticks traversing across BBB, releasing the TMZ payload from TiO 2 nanosticks and reactive oxygen species (ROS) generation from TiO 2 nanosticks within the GBM milieu. The tumor ablation was confirmed by MTT and Annexin(v)-PI assays, apoptotic proteins expression via western blot and ROS level detection in vitro , whereas tumor volume, weight, survival rate, and relative photon flux in the xenograft and orthoptic TMZ-resistant GBM murine models as in vivo. Conclusion We found this nanomedicine-based ultrasound modality highly efficient in GBM treatment and is of future clinical application value due to the employment of already FDA-approved techniques and nanomedicine." @default.
- W3118406422 created "2021-01-18" @default.
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- W3118406422 date "2021-07-10" @default.
- W3118406422 modified "2023-10-11" @default.
- W3118406422 title "Ultrasound-activated nano-TiO2 loaded with temozolomide paves the way for resection of chemoresistant glioblastoma multiforme" @default.
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- W3118406422 doi "https://doi.org/10.1186/s12645-021-00088-6" @default.
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