FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118418576> ?p ?o ?g. }

• W3118418576 abstract "Abstract Background A body distribution with high intramuscular fat and low abdominal fat is the ideal goal for broiler breeding. Preadipocytes with different origins have differences in terms of metabolism and gene expression. The transcriptome analysis performed in this study of intramuscular preadipocytes (DIMFPs) and adipose tissue-derived preadipocytes (DAFPs) aimed to explore the characteristics of lipid deposition in different chicken preadipocytes by dedifferentiation in vitro. Results Compared with DAFPs, the total lipid content in DIMFPs was reduced ( P < 0.05 ). Moreover, 72 DEGs related to lipid metabolism were screened, which were involved in adipocyte differentiation, fatty acid transport and fatty acid synthesis, lipid stabilization, and lipolysis. Among the 72 DEGs, 19 DEGs were enriched in the PPAR signaling pathway, indicating its main contribution to the regulation of the difference in lipid deposition between DAFPs and DIMFPs. Among these 19 genes, the representative APOA1 , ADIPOQ , FABP3 , FABP4 , FABP7 , HMGCS2 , LPL and RXRG genes were downregulated, but the ACSL1 , FABP5 , PCK2 , PDPK1 , PPARG , SCD , SCD5 , and SLC27A6 genes were upregulated ( P < 0.05 or P < 0.01) in the DIMFPs. In addition, the well-known pathways affecting lipid metabolism (MAPK, TGF-beta and calcium) and the pathways related to cell communication were enriched, which may also contribute to the regulation of lipid deposition. Finally, the regulatory network for the difference in lipid deposition between chicken DAFPs and DIMFPs was proposed based on the above information. Conclusions Our data suggested a difference in lipid deposition between DIMFPs and DAFPs of chickens in vitro and proposed a molecular regulatory network for the difference in lipid deposition between chicken DAFPs and DIMFPs. The lipid content was significantly increased in DAFPs by the direct mediation of PPAR signaling pathways. These findings provide new insights into the regulation of tissue-specific fat deposition and the optimization of body fat distribution in broilers." @default.
• W3118418576 created "2021-01-18" @default.
• W3118418576 creator A5012677271 @default.
• W3118418576 creator A5017521861 @default.
• W3118418576 creator A5028519608 @default.
• W3118418576 creator A5045582315 @default.
• W3118418576 creator A5049264813 @default.
• W3118418576 creator A5049555519 @default.
• W3118418576 creator A5072606946 @default.
• W3118418576 creator A5078433811 @default.
• W3118418576 creator A5089530056 @default.
• W3118418576 date "2021-04-03" @default.
• W3118418576 modified "2023-10-17" @default.
• W3118418576 title "Identification of the molecular regulation of differences in lipid deposition in dedifferentiated preadipocytes from different chicken tissues" @default.
• W3118418576 cites W1490184649 @default.
• W3118418576 cites W1978892253 @default.
• W3118418576 cites W1986831880 @default.
• W3118418576 cites W1998896231 @default.
• W3118418576 cites W2005528434 @default.
• W3118418576 cites W2014762278 @default.
• W3118418576 cites W2022554606 @default.
• W3118418576 cites W2028769116 @default.
• W3118418576 cites W2033512683 @default.
• W3118418576 cites W2033762238 @default.
• W3118418576 cites W2036805462 @default.
• W3118418576 cites W2071181652 @default.
• W3118418576 cites W2078756062 @default.
• W3118418576 cites W2098817509 @default.
• W3118418576 cites W2107277218 @default.
• W3118418576 cites W2113286739 @default.
• W3118418576 cites W2131333342 @default.
• W3118418576 cites W2148023110 @default.
• W3118418576 cites W2154431984 @default.
• W3118418576 cites W2166817392 @default.
• W3118418576 cites W2199314036 @default.
• W3118418576 cites W2285841122 @default.
• W3118418576 cites W2315578804 @default.
• W3118418576 cites W2513364222 @default.
• W3118418576 cites W2529379129 @default.
• W3118418576 cites W2603368068 @default.
• W3118418576 cites W2737653105 @default.
• W3118418576 cites W2742741939 @default.
• W3118418576 cites W2753406012 @default.
• W3118418576 cites W2772999440 @default.
• W3118418576 cites W2847741275 @default.
• W3118418576 cites W2972889868 @default.
• W3118418576 cites W2980890829 @default.
• W3118418576 cites W2985018733 @default.
• W3118418576 cites W3003160848 @default.
• W3118418576 cites W3016776790 @default.
• W3118418576 cites W3081278094 @default.
• W3118418576 cites W3096897951 @default.
• W3118418576 cites W4294216483 @default.
• W3118418576 cites W4321429322 @default.
• W3118418576 doi "https://doi.org/10.1186/s12864-021-07459-8" @default.
• W3118418576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8019497" @default.
• W3118418576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33812382" @default.
• W3118418576 hasPublicationYear "2021" @default.
• W3118418576 type Work @default.
• W3118418576 sameAs 3118418576 @default.
• W3118418576 citedByCount "10" @default.
• W3118418576 countsByYear W31184185762021 @default.
• W3118418576 countsByYear W31184185762022 @default.
• W3118418576 countsByYear W31184185762023 @default.
• W3118418576 crossrefType "journal-article" @default.
• W3118418576 hasAuthorship W3118418576A5012677271 @default.
• W3118418576 hasAuthorship W3118418576A5017521861 @default.
• W3118418576 hasAuthorship W3118418576A5028519608 @default.
• W3118418576 hasAuthorship W3118418576A5045582315 @default.
• W3118418576 hasAuthorship W3118418576A5049264813 @default.
• W3118418576 hasAuthorship W3118418576A5049555519 @default.
• W3118418576 hasAuthorship W3118418576A5072606946 @default.
• W3118418576 hasAuthorship W3118418576A5078433811 @default.
• W3118418576 hasAuthorship W3118418576A5089530056 @default.
• W3118418576 hasBestOaLocation W31184185761 @default.
• W3118418576 hasConcept C104317684 @default.
• W3118418576 hasConcept C126322002 @default.
• W3118418576 hasConcept C134018914 @default.
• W3118418576 hasConcept C140985366 @default.
• W3118418576 hasConcept C150194340 @default.
• W3118418576 hasConcept C162317418 @default.
• W3118418576 hasConcept C171089720 @default.
• W3118418576 hasConcept C25095133 @default.
• W3118418576 hasConcept C2776175234 @default.
• W3118418576 hasConcept C2776635132 @default.
• W3118418576 hasConcept C2779828298 @default.
• W3118418576 hasConcept C4733338 @default.
• W3118418576 hasConcept C543025807 @default.
• W3118418576 hasConcept C55493867 @default.
• W3118418576 hasConcept C71924100 @default.
• W3118418576 hasConcept C86803240 @default.
• W3118418576 hasConceptScore W3118418576C104317684 @default.
• W3118418576 hasConceptScore W3118418576C126322002 @default.
• W3118418576 hasConceptScore W3118418576C134018914 @default.
• W3118418576 hasConceptScore W3118418576C140985366 @default.
• W3118418576 hasConceptScore W3118418576C150194340 @default.
• W3118418576 hasConceptScore W3118418576C162317418 @default.
• W3118418576 hasConceptScore W3118418576C171089720 @default.
• W3118418576 hasConceptScore W3118418576C25095133 @default.
• W3118418576 hasConceptScore W3118418576C2776175234 @default.

• next