Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118424178> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3118424178 endingPage "S835" @default.
- W3118424178 startingPage "S834" @default.
- W3118424178 abstract "Abstract Background Valganciclovir (VGC), an oral prodrug of ganciclovir (GCV), is 60% bioavailable. Manufacturer-recommended doses are adjusted for creatinine clearance (CrCl), but not weight (wt), while GCV doses are adjusted for CrCl and wt. Patients exposed to excess GCV by not wt-adjusting VGC doses may be at risk of hematologic toxicity. The purpose of this study was to investigate the impact of body weight on VGC toxicity in solid organ transplant (SOT) recipients. Methods This was a multicenter retrospective study at three academic medical centers of adult SOT recipients who received VGC for CMV prophylaxis between January 2016 and August 2019. The primary outcome was first occurrence of leukopenia within six months post-transplant. The primary predictor was the ratio between the patient’s estimated GCV exposure based on the initial VGC dose prescribed and the equivalent prophylactic GCV dose accounting for the patient’s CrCl and wt (rVGC:GCV). Results The study included 231 patients, mostly lung (59%) and kidney (KT, 28%) transplants (Table 1). The rVGCV:GCV was 4.4 (range, 0.6-25.1, SD 4.5), and was significantly higher in KT (7.7 vs 3.0, p < 0.001). Leukopenia occurred in 133 patients (57.5%). After adjustment for type of transplant, rVGC:GCV ratio was not associated with increased odds (OR 0.97, 95% CI 0.91-1.04) or hazard of (HR 0.99, 95% CI 0.95-1.04) leukopenia. Exploratory analysis suggested threshold effects and interaction with transplant type: a rVGCV:VGC of > 3 was associated with time to leukopenia (HR 2.02, 95% CI 1.09-3.74) among non-KT patients but not KT patients (HR 0.99, 95% CI 0.56-1.76) (Figure 1). Table 1 Figure 1 Conclusion Initial doses of VGC used for SOT CMV prophylaxis are estimated to result in significantly higher GCV exposures than IV GCV doses. A relationship with risk of leukopenia was only seen in non-KT patients, possibly because of rapid recovery of renal function and dose adjustment in KT patients. Disclosures Jason C. Gallagher, PharmD, FIDP, FCCP, FIDSA, BCPS, Allergan (Consultant)Astellas (Consultant)Merck (Consultant, Grant/Research Support)Nabriva (Consultant)Qpex (Consultant)scPharmaceuticals (Consultant)Shionogi (Consultant)Spero (Consultant)Tetraphase (Consultant)" @default.
- W3118424178 created "2021-01-18" @default.
- W3118424178 creator A5007968839 @default.
- W3118424178 creator A5026787087 @default.
- W3118424178 creator A5026965181 @default.
- W3118424178 creator A5033772317 @default.
- W3118424178 creator A5039537858 @default.
- W3118424178 creator A5059487804 @default.
- W3118424178 date "2020-10-01" @default.
- W3118424178 modified "2023-10-16" @default.
- W3118424178 title "1703. Hematologic Toxicity of Valganciclovir Prophylaxis in Solid Organ Transplant Recipients as a Function of Weight-adjusted Ganciclovir Exposure" @default.
- W3118424178 doi "https://doi.org/10.1093/ofid/ofaa439.1881" @default.
- W3118424178 hasPublicationYear "2020" @default.
- W3118424178 type Work @default.
- W3118424178 sameAs 3118424178 @default.
- W3118424178 citedByCount "0" @default.
- W3118424178 crossrefType "journal-article" @default.
- W3118424178 hasAuthorship W3118424178A5007968839 @default.
- W3118424178 hasAuthorship W3118424178A5026787087 @default.
- W3118424178 hasAuthorship W3118424178A5026965181 @default.
- W3118424178 hasAuthorship W3118424178A5033772317 @default.
- W3118424178 hasAuthorship W3118424178A5039537858 @default.
- W3118424178 hasAuthorship W3118424178A5059487804 @default.
- W3118424178 hasBestOaLocation W31184241781 @default.
- W3118424178 hasConcept C126322002 @default.
- W3118424178 hasConcept C126894567 @default.
- W3118424178 hasConcept C141071460 @default.
- W3118424178 hasConcept C159641895 @default.
- W3118424178 hasConcept C203014093 @default.
- W3118424178 hasConcept C207103383 @default.
- W3118424178 hasConcept C2522874641 @default.
- W3118424178 hasConcept C2776317777 @default.
- W3118424178 hasConcept C2777965375 @default.
- W3118424178 hasConcept C2779820661 @default.
- W3118424178 hasConcept C2780873365 @default.
- W3118424178 hasConcept C29730261 @default.
- W3118424178 hasConcept C44249647 @default.
- W3118424178 hasConcept C71924100 @default.
- W3118424178 hasConcept C90924648 @default.
- W3118424178 hasConceptScore W3118424178C126322002 @default.
- W3118424178 hasConceptScore W3118424178C126894567 @default.
- W3118424178 hasConceptScore W3118424178C141071460 @default.
- W3118424178 hasConceptScore W3118424178C159641895 @default.
- W3118424178 hasConceptScore W3118424178C203014093 @default.
- W3118424178 hasConceptScore W3118424178C207103383 @default.
- W3118424178 hasConceptScore W3118424178C2522874641 @default.
- W3118424178 hasConceptScore W3118424178C2776317777 @default.
- W3118424178 hasConceptScore W3118424178C2777965375 @default.
- W3118424178 hasConceptScore W3118424178C2779820661 @default.
- W3118424178 hasConceptScore W3118424178C2780873365 @default.
- W3118424178 hasConceptScore W3118424178C29730261 @default.
- W3118424178 hasConceptScore W3118424178C44249647 @default.
- W3118424178 hasConceptScore W3118424178C71924100 @default.
- W3118424178 hasConceptScore W3118424178C90924648 @default.
- W3118424178 hasIssue "Supplement_1" @default.
- W3118424178 hasLocation W31184241781 @default.
- W3118424178 hasLocation W31184241782 @default.
- W3118424178 hasLocation W31184241783 @default.
- W3118424178 hasOpenAccess W3118424178 @default.
- W3118424178 hasPrimaryLocation W31184241781 @default.
- W3118424178 hasRelatedWork W12494486 @default.
- W3118424178 hasRelatedWork W12731474 @default.
- W3118424178 hasRelatedWork W13840798 @default.
- W3118424178 hasRelatedWork W17696164 @default.
- W3118424178 hasRelatedWork W18214132 @default.
- W3118424178 hasRelatedWork W18903012 @default.
- W3118424178 hasRelatedWork W3890397 @default.
- W3118424178 hasRelatedWork W6623693 @default.
- W3118424178 hasRelatedWork W6871978 @default.
- W3118424178 hasRelatedWork W8880177 @default.
- W3118424178 hasVolume "7" @default.
- W3118424178 isParatext "false" @default.
- W3118424178 isRetracted "false" @default.
- W3118424178 magId "3118424178" @default.
- W3118424178 workType "article" @default.