FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118443275> ?p ?o ?g. }

• W3118443275 endingPage "S104" @default.
• W3118443275 startingPage "S103" @default.
• W3118443275 abstract "Abstract Background Cancer patients (pts) frequently receive empiric antibiotics without clear indication. This retrospective study investigated the relationship between the systemic inflammatory response syndrome (SIRS), early antibiotic (Anb) use, and bacteremia in solid tumor pts presenting to the emergency department (ED). Methods We extracted data from the electronic medical records of adults with solid tumors admitted to a tertiary care hospital through the ED for any reason over a 2 year period. Pts with neutropenic fever, organ transplant, trauma, or cardiopulmonary arrest were excluded. Rates of SIRS and bacteremia among pts receiving early Anb (eAnb, within 8 hours of admission) were compared to all others using χ 2. Binomial regression and receiver operator curves assessed predictors of bacteremia. Results Of 3580 eligible pts, 1344 pts were SIRS positive (≥ 2 criteria) and 2236 were SIRS negative; 501 (37%) and 493 (22%), respectively, received eAnb (p&lt; 0.001). eAnb use increased with additional SIRS criteria (Fig 1). Of SIRS positive pts, 860 (64%) had BCs drawn within 48 hrs of presentation, of which 19% were positive. Of SIRS negative pts, 826 (37%) had cultures drawn within 48 hrs of presentation, of which 14% were positive (19% vs 14%, p=0.004). Of pts who had BCs drawn, the proportion of positive BCs among those who received eAnb and those who did not was identical (16% in each group; p=1). Of 276 pts ultimately proven to have bacteremia within 48 hrs, only 59% were SIRS positive, and only 49% received eAnb in the ED. By regression, only two SIRS components predicted bacteremia, fever (OR 1.8 ± 0.39, p=0.01) and tachycardia (1.4 ± 0.22, p=0.03), and SIRS criteria as a whole were poorly predictive of bacteremia (AUC 0.57, Table 1). A more robust model, which included additional labs and vital signs, was only marginally better (AUC 0.61, Table 2). Figure 1: Proportion of patients receiving early antibiotics by SIRS score Table 1: SIRS as a predictor of bacteremia Table 2: Best predictive model of bacteremia Conclusion Clinicians still use SIRS criteria to determine the need for eAnb. However, SIRS criteria are poor predictors of bacteremia in solid tumor pts, who frequently manifest them due to complications of cancer or cancer-directed therapy rather than infection. Furthermore, patients who are SIRS negative may be bacteremic. More reliable models are needed to guide judicious use of Anb in the solid tumor population. Disclosures All Authors: No reported disclosures" @default.
• W3118443275 created "2021-01-18" @default.
• W3118443275 creator A5033027008 @default.
• W3118443275 creator A5033234911 @default.
• W3118443275 creator A5050671493 @default.
• W3118443275 creator A5068082924 @default.
• W3118443275 date "2020-10-01" @default.
• W3118443275 modified "2023-09-23" @default.
• W3118443275 title "198. Clinical Prediction of Bacteremia and the Need for Early Antibiotic Therapy in Solid Tumor Cancer Patients" @default.
• W3118443275 doi "https://doi.org/10.1093/ofid/ofaa439.242" @default.
• W3118443275 hasPublicationYear "2020" @default.
• W3118443275 type Work @default.
• W3118443275 sameAs 3118443275 @default.
• W3118443275 citedByCount "0" @default.
• W3118443275 crossrefType "journal-article" @default.
• W3118443275 hasAuthorship W3118443275A5033027008 @default.
• W3118443275 hasAuthorship W3118443275A5033234911 @default.
• W3118443275 hasAuthorship W3118443275A5050671493 @default.
• W3118443275 hasAuthorship W3118443275A5068082924 @default.
• W3118443275 hasBestOaLocation W31184432751 @default.
• W3118443275 hasConcept C118552586 @default.
• W3118443275 hasConcept C121608353 @default.
• W3118443275 hasConcept C126322002 @default.
• W3118443275 hasConcept C167135981 @default.
• W3118443275 hasConcept C2778384902 @default.
• W3118443275 hasConcept C2779443120 @default.
• W3118443275 hasConcept C2780724011 @default.
• W3118443275 hasConcept C2781090800 @default.
• W3118443275 hasConcept C501593827 @default.
• W3118443275 hasConcept C71924100 @default.
• W3118443275 hasConcept C86803240 @default.
• W3118443275 hasConcept C89423630 @default.
• W3118443275 hasConceptScore W3118443275C118552586 @default.
• W3118443275 hasConceptScore W3118443275C121608353 @default.
• W3118443275 hasConceptScore W3118443275C126322002 @default.
• W3118443275 hasConceptScore W3118443275C167135981 @default.
• W3118443275 hasConceptScore W3118443275C2778384902 @default.
• W3118443275 hasConceptScore W3118443275C2779443120 @default.
• W3118443275 hasConceptScore W3118443275C2780724011 @default.
• W3118443275 hasConceptScore W3118443275C2781090800 @default.
• W3118443275 hasConceptScore W3118443275C501593827 @default.
• W3118443275 hasConceptScore W3118443275C71924100 @default.
• W3118443275 hasConceptScore W3118443275C86803240 @default.
• W3118443275 hasConceptScore W3118443275C89423630 @default.
• W3118443275 hasIssue "Supplement_1" @default.
• W3118443275 hasLocation W31184432751 @default.
• W3118443275 hasLocation W31184432752 @default.
• W3118443275 hasLocation W31184432753 @default.
• W3118443275 hasOpenAccess W3118443275 @default.
• W3118443275 hasPrimaryLocation W31184432751 @default.
• W3118443275 hasRelatedWork W10741706 @default.
• W3118443275 hasRelatedWork W11093380 @default.
• W3118443275 hasRelatedWork W12355033 @default.
• W3118443275 hasRelatedWork W16072843 @default.
• W3118443275 hasRelatedWork W17038076 @default.
• W3118443275 hasRelatedWork W3519569 @default.
• W3118443275 hasRelatedWork W5996334 @default.
• W3118443275 hasRelatedWork W7811702 @default.
• W3118443275 hasRelatedWork W8605139 @default.
• W3118443275 hasRelatedWork W19473011 @default.
• W3118443275 hasVolume "7" @default.
• W3118443275 isParatext "false" @default.
• W3118443275 isRetracted "false" @default.
• W3118443275 magId "3118443275" @default.
• W3118443275 workType "article" @default.