FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118478737> ?p ?o ?g. }

• W3118478737 endingPage "108579" @default.
• W3118478737 startingPage "108579" @default.
• W3118478737 abstract "O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) is a unique enzyme introducing O-GlcNAc moiety on target proteins, and it critically regulates various cellular processes in diverse cell types. However, its roles in hematopoietic stem and progenitor cells (HSPCs) remain elusive. Here, using Ogt conditional knockout mice, we show that OGT is essential for HSPCs. Ogt is highly expressed in HSPCs, and its disruption induces rapid loss of HSPCs with increased reactive oxygen species and apoptosis. In particular, Ogt-deficient hematopoietic stem cells (HSCs) lose quiescence, cannot be maintained in vivo, and become vulnerable to regenerative and competitive stress. Interestingly, Ogt-deficient HSCs accumulate defective mitochondria due to impaired mitophagy with decreased key mitophagy regulator, Pink1, through dysregulation of H3K4me3. Furthermore, overexpression of PINK1 restores mitophagy and the number of Ogt-deficient HSCs. Collectively, our results reveal that OGT critically regulates maintenance and stress response of HSCs by ensuring mitochondrial quality through PINK1-dependent mitophagy." @default.
• W3118478737 created "2021-01-18" @default.
• W3118478737 creator A5000336395 @default.
• W3118478737 creator A5002357141 @default.
• W3118478737 creator A5005105498 @default.
• W3118478737 creator A5005213203 @default.
• W3118478737 creator A5009363901 @default.
• W3118478737 creator A5010172641 @default.
• W3118478737 creator A5014442377 @default.
• W3118478737 creator A5022935726 @default.
• W3118478737 creator A5023580077 @default.
• W3118478737 creator A5026161536 @default.
• W3118478737 creator A5029593209 @default.
• W3118478737 creator A5036193214 @default.
• W3118478737 creator A5043894598 @default.
• W3118478737 creator A5044647383 @default.
• W3118478737 creator A5050855780 @default.
• W3118478737 creator A5052011362 @default.
• W3118478737 creator A5052090382 @default.
• W3118478737 creator A5067715504 @default.
• W3118478737 creator A5073658591 @default.
• W3118478737 creator A5081617473 @default.
• W3118478737 creator A5082668676 @default.
• W3118478737 creator A5086949282 @default.
• W3118478737 creator A5088494477 @default.
• W3118478737 date "2021-01-01" @default.
• W3118478737 modified "2023-10-17" @default.
• W3118478737 title "OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy" @default.
• W3118478737 cites W1570460795 @default.
• W3118478737 cites W1968197570 @default.
• W3118478737 cites W1974182237 @default.
• W3118478737 cites W1979058918 @default.
• W3118478737 cites W1985119207 @default.
• W3118478737 cites W1995091371 @default.
• W3118478737 cites W2009195999 @default.
• W3118478737 cites W2011059916 @default.
• W3118478737 cites W2014459126 @default.
• W3118478737 cites W2018024152 @default.
• W3118478737 cites W2019443416 @default.
• W3118478737 cites W2019455536 @default.
• W3118478737 cites W2021209236 @default.
• W3118478737 cites W2023620203 @default.
• W3118478737 cites W2027661066 @default.
• W3118478737 cites W2032197035 @default.
• W3118478737 cites W2034132952 @default.
• W3118478737 cites W2041801261 @default.
• W3118478737 cites W2044370075 @default.
• W3118478737 cites W2048934049 @default.
• W3118478737 cites W2049279804 @default.
• W3118478737 cites W2049311574 @default.
• W3118478737 cites W2051948190 @default.
• W3118478737 cites W2052904272 @default.
• W3118478737 cites W2055309955 @default.
• W3118478737 cites W2055807959 @default.
• W3118478737 cites W2061237420 @default.
• W3118478737 cites W2068936500 @default.
• W3118478737 cites W2069918359 @default.
• W3118478737 cites W2070151086 @default.
• W3118478737 cites W2074516296 @default.
• W3118478737 cites W2107279676 @default.
• W3118478737 cites W2109361919 @default.
• W3118478737 cites W2114104545 @default.
• W3118478737 cites W2120036668 @default.
• W3118478737 cites W2124733101 @default.
• W3118478737 cites W2130410032 @default.
• W3118478737 cites W2136331786 @default.
• W3118478737 cites W2138311396 @default.
• W3118478737 cites W2151024354 @default.
• W3118478737 cites W2180342052 @default.
• W3118478737 cites W2233886519 @default.
• W3118478737 cites W2313855869 @default.
• W3118478737 cites W2337123977 @default.
• W3118478737 cites W2343796589 @default.
• W3118478737 cites W2464384284 @default.
• W3118478737 cites W2531784077 @default.
• W3118478737 cites W2576311803 @default.
• W3118478737 cites W2592615787 @default.
• W3118478737 cites W2610977937 @default.
• W3118478737 cites W2613861803 @default.
• W3118478737 cites W2737043580 @default.
• W3118478737 cites W2768858549 @default.
• W3118478737 cites W2769575215 @default.
• W3118478737 cites W2772722011 @default.
• W3118478737 cites W2783409125 @default.
• W3118478737 cites W2799842393 @default.
• W3118478737 cites W2803147266 @default.
• W3118478737 cites W2887998229 @default.
• W3118478737 cites W2900119089 @default.
• W3118478737 cites W2903482407 @default.
• W3118478737 cites W2905094310 @default.
• W3118478737 cites W2911143204 @default.
• W3118478737 cites W2970388083 @default.
• W3118478737 cites W2980344383 @default.
• W3118478737 cites W3006297827 @default.
• W3118478737 cites W3007233540 @default.
• W3118478737 cites W629466480 @default.
• W3118478737 doi "https://doi.org/10.1016/j.celrep.2020.108579" @default.
• W3118478737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33406421" @default.

• next