FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118487076> ?p ?o ?g. }

• W3118487076 abstract "Abstract Background SARS coronavirus 2 (SARS-CoV-2) is responsible for high morbidity and mortality worldwide, mostly due to the exacerbated inflammatory response observed in critically ill patients. However, little is known about the kinetics of the systemic immune response and its association with survival in SARS-CoV-2+ patients admitted in ICU. We aimed to compare the immuno-inflammatory features according to organ failure severity and in-ICU mortality. Methods Six-week multicentre study ( N = 3) including SARS-CoV-2+ patients admitted in ICU. Analysis of plasma biomarkers at days 0 and 3–4 according to organ failure worsening (increase in SOFA score) and 60-day mortality. Results 101 patients were included. Patients had severe respiratory diseases with PaO2/FiO2 of 155 [111–251] mmHg), SAPS II of 37 [31–45] and SOFA score of 4 [3–7]. Eighty-three patients (83%) required endotracheal intubation/mechanical ventilation and among them, 64% were treated with prone position. IL-1β was barely detectable. Baseline IL-6 levels positively correlated with organ failure severity. Baseline IL-6 and CRP levels were significantly higher in patients in the worsening group than in the non-worsening group (278 [70–622] vs. 71 [29–153] pg/mL, P < 0.01; and 178 [100–295] vs. 100 [37–213] mg/L, P < 0.05, respectively). Baseline IL-6 and CRP levels were significantly higher in non-survivors compared to survivors but fibrinogen levels and lymphocyte counts were not different between groups. After adjustment on SOFA score and time from symptom onset to first dosage, IL-6 and CRP remained significantly associated with mortality. IL-6 changes between Day 0 and Day 3–4 were not different according to the outcome. A contrario , kinetics of CRP and lymphocyte count were different between survivors and non-survivors. Conclusions In SARS-CoV-2+ patients admitted in ICU, a systemic pro-inflammatory signature was associated with clinical worsening and 60-day mortality." @default.
• W3118487076 created "2021-01-18" @default.
• W3118487076 creator A5012908221 @default.
• W3118487076 creator A5016535365 @default.
• W3118487076 creator A5017203226 @default.
• W3118487076 creator A5018007709 @default.
• W3118487076 creator A5024477949 @default.
• W3118487076 creator A5025425418 @default.
• W3118487076 creator A5034819453 @default.
• W3118487076 creator A5038388507 @default.
• W3118487076 creator A5043310848 @default.
• W3118487076 creator A5061491747 @default.
• W3118487076 creator A5061562246 @default.
• W3118487076 creator A5063427876 @default.
• W3118487076 creator A5072996405 @default.
• W3118487076 creator A5073173280 @default.
• W3118487076 creator A5075184503 @default.
• W3118487076 creator A5080411088 @default.
• W3118487076 creator A5081636619 @default.
• W3118487076 creator A5082387473 @default.
• W3118487076 creator A5086607741 @default.
• W3118487076 creator A5087187401 @default.
• W3118487076 creator A5087333640 @default.
• W3118487076 date "2021-01-13" @default.
• W3118487076 modified "2023-10-18" @default.
• W3118487076 title "Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients" @default.
• W3118487076 cites W1852206174 @default.
• W3118487076 cites W1947409115 @default.
• W3118487076 cites W1986187535 @default.
• W3118487076 cites W2073275833 @default.
• W3118487076 cites W2075856463 @default.
• W3118487076 cites W2078121682 @default.
• W3118487076 cites W2102095525 @default.
• W3118487076 cites W2132260239 @default.
• W3118487076 cites W2151578177 @default.
• W3118487076 cites W2166221102 @default.
• W3118487076 cites W2166867592 @default.
• W3118487076 cites W2325491525 @default.
• W3118487076 cites W2591419591 @default.
• W3118487076 cites W2798105113 @default.
• W3118487076 cites W2903302497 @default.
• W3118487076 cites W3001118548 @default.
• W3118487076 cites W3004280078 @default.
• W3118487076 cites W3010338568 @default.
• W3118487076 cites W3014003872 @default.
• W3118487076 cites W3014294089 @default.
• W3118487076 cites W3016288338 @default.
• W3118487076 cites W3019471008 @default.
• W3118487076 cites W3019785070 @default.
• W3118487076 cites W3019953082 @default.
• W3118487076 cites W3044304208 @default.
• W3118487076 cites W3080981445 @default.
• W3118487076 cites W3093261446 @default.
• W3118487076 cites W3165656738 @default.
• W3118487076 cites W4247943214 @default.
• W3118487076 doi "https://doi.org/10.1186/s13613-020-00798-x" @default.
• W3118487076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8188151" @default.
• W3118487076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34106340" @default.
• W3118487076 hasPublicationYear "2021" @default.
• W3118487076 type Work @default.
• W3118487076 sameAs 3118487076 @default.
• W3118487076 citedByCount "65" @default.
• W3118487076 countsByYear W31184870762021 @default.
• W3118487076 countsByYear W31184870762022 @default.
• W3118487076 countsByYear W31184870762023 @default.
• W3118487076 crossrefType "journal-article" @default.
• W3118487076 hasAuthorship W3118487076A5012908221 @default.
• W3118487076 hasAuthorship W3118487076A5016535365 @default.
• W3118487076 hasAuthorship W3118487076A5017203226 @default.
• W3118487076 hasAuthorship W3118487076A5018007709 @default.
• W3118487076 hasAuthorship W3118487076A5024477949 @default.
• W3118487076 hasAuthorship W3118487076A5025425418 @default.
• W3118487076 hasAuthorship W3118487076A5034819453 @default.
• W3118487076 hasAuthorship W3118487076A5038388507 @default.
• W3118487076 hasAuthorship W3118487076A5043310848 @default.
• W3118487076 hasAuthorship W3118487076A5061491747 @default.
• W3118487076 hasAuthorship W3118487076A5061562246 @default.
• W3118487076 hasAuthorship W3118487076A5063427876 @default.
• W3118487076 hasAuthorship W3118487076A5072996405 @default.
• W3118487076 hasAuthorship W3118487076A5073173280 @default.
• W3118487076 hasAuthorship W3118487076A5075184503 @default.
• W3118487076 hasAuthorship W3118487076A5080411088 @default.
• W3118487076 hasAuthorship W3118487076A5081636619 @default.
• W3118487076 hasAuthorship W3118487076A5082387473 @default.
• W3118487076 hasAuthorship W3118487076A5086607741 @default.
• W3118487076 hasAuthorship W3118487076A5087187401 @default.
• W3118487076 hasAuthorship W3118487076A5087333640 @default.
• W3118487076 hasBestOaLocation W31184870761 @default.
• W3118487076 hasConcept C126322002 @default.
• W3118487076 hasConcept C2776252253 @default.
• W3118487076 hasConcept C2776376669 @default.
• W3118487076 hasConcept C2776888751 @default.
• W3118487076 hasConcept C2776914184 @default.
• W3118487076 hasConcept C2777080012 @default.
• W3118487076 hasConcept C2777465075 @default.
• W3118487076 hasConcept C2778716859 @default.
• W3118487076 hasConcept C2779526319 @default.
• W3118487076 hasConcept C30036603 @default.
• W3118487076 hasConcept C42219234 @default.
• W3118487076 hasConcept C71924100 @default.

• next