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- W3118491421 abstract "Objectives: In Wilms Tumor (WT) secondary malignancies caused by the side effects of intensive treatments remain one of the important problems. Therefore, there is a need for new studies to identify low- and high-risk groups for WT and to improve the treatment regimens of children in the low-risk group. Therefore, in our study, we aimed to determine the prognostic significance of the cyclooxygenase-2 (COX-2) biomarker in WT. Materials and Methods: Our study included 24 patients diagnosed with WT between January 2010 and December 2019. The correlation between COX-2 expression and significant prognostic parameters was investigated by studying COX-2 antibody using the immunohistochemical method. Results: COX-2 expression was observed in 22 of the patients, and the expression was more evident especially in the epithelial component. There was no significant correlation between COX-2 positivity and prognostic parameters. Conclusions: In our study, no significant relationship was found between significant prognostic parameters and COX-2 expression. We think that the COX-2 pathway is effective during the development phase of WT, since COX-2 expression was observed in almost all patients, therefore it may be beneficial to add COX-2 inhibitors to the treatment, and that a sufficient number of studies should be conducted in this respect." @default.
- W3118491421 created "2021-01-18" @default.
- W3118491421 creator A5014700239 @default.
- W3118491421 creator A5089795895 @default.
- W3118491421 date "2020-12-29" @default.
- W3118491421 modified "2023-09-23" @default.
- W3118491421 title "Prognostic Significance of COX-2 Expression in Wilms' Tumor" @default.
- W3118491421 doi "https://doi.org/10.22541/au.160924069.93875109/v1" @default.
- W3118491421 hasPublicationYear "2020" @default.
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