Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118496387> ?p ?o ?g. }
- W3118496387 endingPage "378" @default.
- W3118496387 startingPage "364" @default.
- W3118496387 abstract "The existing approaches for healing mandibular condylar osteochondral defects, which are prevalent in temporomandibular joint disorders (TMD), are sparse and not reparative. To address this, regenerative medicine in situ has transpired as a potential therapeutic solution as it can effectively regenerate composite tissues. Herein, injectable self-crosslinking thiolated hyaluronic acid (HA-SH)/type I collagen (Col I) blend hydrogel and BCP ceramics combined with rabbit bone mesenchymal stem cells (rBMSCs)/chondrocytes were used to fabricate a new bi-layer scaffold to simulate specific structure of rabbit condylar osteochondral defects. The in vitro results demonstrated that the blend hydrogel scaffold provided suitable microenvironment for simultaneously realizing proliferation and chondrogenic specific matrix secretion of both rBMSCs and chondrocytes, while BCP ceramics facilitated rBMSCs proliferation and osteogenic differentiation. The in vivo results confirmed that compared with cell-free implant, the rBMSCs/chondrocytes-loaded bi-layer scaffold could effectively promote the regeneration of both fibrocartilage and subchondral bone, suggesting that the bi-layer scaffold presented a promising option for cell-mediated mandibular condylar cartilage regeneration." @default.
- W3118496387 created "2021-01-18" @default.
- W3118496387 creator A5014318984 @default.
- W3118496387 creator A5040959671 @default.
- W3118496387 creator A5048864122 @default.
- W3118496387 creator A5063533426 @default.
- W3118496387 creator A5067189270 @default.
- W3118496387 creator A5069206830 @default.
- W3118496387 creator A5071026135 @default.
- W3118496387 creator A5072277102 @default.
- W3118496387 creator A5087454640 @default.
- W3118496387 creator A5091791565 @default.
- W3118496387 date "2021-03-01" @default.
- W3118496387 modified "2023-09-25" @default.
- W3118496387 title "Cell-mediated injectable blend hydrogel-BCP ceramic scaffold for in situ condylar osteochondral repair" @default.
- W3118496387 cites W1527621576 @default.
- W3118496387 cites W1564650535 @default.
- W3118496387 cites W1918719004 @default.
- W3118496387 cites W1965177570 @default.
- W3118496387 cites W1988530401 @default.
- W3118496387 cites W1989312946 @default.
- W3118496387 cites W2004526732 @default.
- W3118496387 cites W2021143006 @default.
- W3118496387 cites W2021224420 @default.
- W3118496387 cites W2022377256 @default.
- W3118496387 cites W2027905532 @default.
- W3118496387 cites W2040056294 @default.
- W3118496387 cites W2040689246 @default.
- W3118496387 cites W2041401385 @default.
- W3118496387 cites W2050008980 @default.
- W3118496387 cites W2054129051 @default.
- W3118496387 cites W2057349098 @default.
- W3118496387 cites W2061062077 @default.
- W3118496387 cites W2071261725 @default.
- W3118496387 cites W2074246845 @default.
- W3118496387 cites W2080846775 @default.
- W3118496387 cites W2090146091 @default.
- W3118496387 cites W2090977911 @default.
- W3118496387 cites W2095598603 @default.
- W3118496387 cites W2099748589 @default.
- W3118496387 cites W2101195334 @default.
- W3118496387 cites W2129431680 @default.
- W3118496387 cites W2133096089 @default.
- W3118496387 cites W2154816802 @default.
- W3118496387 cites W2164880987 @default.
- W3118496387 cites W2226812708 @default.
- W3118496387 cites W2322190065 @default.
- W3118496387 cites W2339936856 @default.
- W3118496387 cites W2468418787 @default.
- W3118496387 cites W2527936520 @default.
- W3118496387 cites W2616272279 @default.
- W3118496387 cites W2626007220 @default.
- W3118496387 cites W2724205981 @default.
- W3118496387 cites W2744149796 @default.
- W3118496387 cites W2772429441 @default.
- W3118496387 cites W2781891680 @default.
- W3118496387 cites W2791374813 @default.
- W3118496387 cites W2887299383 @default.
- W3118496387 cites W2898290235 @default.
- W3118496387 cites W2905343977 @default.
- W3118496387 cites W2914994953 @default.
- W3118496387 cites W2943188777 @default.
- W3118496387 cites W4245265600 @default.
- W3118496387 doi "https://doi.org/10.1016/j.actbio.2020.12.056" @default.
- W3118496387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33453407" @default.
- W3118496387 hasPublicationYear "2021" @default.
- W3118496387 type Work @default.
- W3118496387 sameAs 3118496387 @default.
- W3118496387 citedByCount "16" @default.
- W3118496387 countsByYear W31184963872021 @default.
- W3118496387 countsByYear W31184963872022 @default.
- W3118496387 countsByYear W31184963872023 @default.
- W3118496387 crossrefType "journal-article" @default.
- W3118496387 hasAuthorship W3118496387A5014318984 @default.
- W3118496387 hasAuthorship W3118496387A5040959671 @default.
- W3118496387 hasAuthorship W3118496387A5048864122 @default.
- W3118496387 hasAuthorship W3118496387A5063533426 @default.
- W3118496387 hasAuthorship W3118496387A5067189270 @default.
- W3118496387 hasAuthorship W3118496387A5069206830 @default.
- W3118496387 hasAuthorship W3118496387A5071026135 @default.
- W3118496387 hasAuthorship W3118496387A5072277102 @default.
- W3118496387 hasAuthorship W3118496387A5087454640 @default.
- W3118496387 hasAuthorship W3118496387A5091791565 @default.
- W3118496387 hasConcept C105702510 @default.
- W3118496387 hasConcept C10854531 @default.
- W3118496387 hasConcept C136229726 @default.
- W3118496387 hasConcept C142724271 @default.
- W3118496387 hasConcept C171056886 @default.
- W3118496387 hasConcept C192562407 @default.
- W3118496387 hasConcept C198826908 @default.
- W3118496387 hasConcept C204787440 @default.
- W3118496387 hasConcept C2776164576 @default.
- W3118496387 hasConcept C2777529286 @default.
- W3118496387 hasConcept C2780550940 @default.
- W3118496387 hasConcept C2781218938 @default.
- W3118496387 hasConcept C28328180 @default.
- W3118496387 hasConcept C3020332539 @default.
- W3118496387 hasConcept C35496256 @default.