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• W3118507382 abstract "Inflammatory disorders like diabetes, systemic lupus erythematodes, inflammatory lung diseases, rheumatoid arthritis and multiple sclerosis, but also rejection of transplanted organs and GvHD, form a major burden of disease. Current classes of immune suppressive drugs to treat these disorders are never curative and side effects are common. Therefore there is a need for new drugs with improved and more targeted modes of action. Potential candidates are the DNA methyl transferase inhibitor 5-azacytidine (Aza) and its derivative 5-aza 2'deoxycitidine (DAC). Aza and DAC have been tested in several pre-clinical in vivo studies. In order to obtain an overview of disorders for which Aza and/or DAC can be a potential treatment, and to find out where information is lacking, we systematically reviewed pre-clinical animal studies assessing Aza or DAC as a potential therapy for distinct inflammatory disorders. Also, study quality and risk of bias was systematically assessed. In the 35 identified studies, we show that both Aza and DAC do not only seem to be able to alleviate a number of inflammatory disorders, but also prevent solid organ rejection and GvHD in in vivo pre-clinical animal models. Aza/DAC are known to upregulate FOXP3, a master transcription factor for Treg, in vitro. Seventeen studies described the effect on Treg, of which 16 studies showed an increase in Treg. Increasing Treg therefore seems to be a common mechanism in preventing inflammatory disorders by Aza/DAC. We also found, however, that many essential methodological details were poorly reported leading to an unclear risk of bias. Therefore, reported effects might be an overestimation of the true effect." @default.
• W3118507382 created "2021-01-18" @default.
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• W3118507382 date "2021-01-06" @default.
• W3118507382 modified "2023-10-12" @default.
• W3118507382 title "Immune responses to azacytidine in animal models of inflammatory disorders: a systematic review" @default.
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• W3118507382 cites W176299508 @default.
• W3118507382 cites W1918204060 @default.
• W3118507382 cites W1955453756 @default.
• W3118507382 cites W1974450480 @default.
• W3118507382 cites W1982333846 @default.
• W3118507382 cites W1987392597 @default.
• W3118507382 cites W2004848541 @default.
• W3118507382 cites W2007520054 @default.
• W3118507382 cites W2010070416 @default.
• W3118507382 cites W2017394727 @default.
• W3118507382 cites W2020170592 @default.
• W3118507382 cites W2021010625 @default.
• W3118507382 cites W2025667794 @default.
• W3118507382 cites W2029385426 @default.
• W3118507382 cites W2031006855 @default.
• W3118507382 cites W2034234108 @default.
• W3118507382 cites W2038581469 @default.
• W3118507382 cites W2042586707 @default.
• W3118507382 cites W2043276364 @default.
• W3118507382 cites W2047808599 @default.
• W3118507382 cites W2049069390 @default.
• W3118507382 cites W2050392402 @default.
• W3118507382 cites W2051877520 @default.
• W3118507382 cites W2052522631 @default.
• W3118507382 cites W2052605694 @default.
• W3118507382 cites W2053084899 @default.
• W3118507382 cites W2054545444 @default.
• W3118507382 cites W2058571677 @default.
• W3118507382 cites W2077477281 @default.
• W3118507382 cites W2079676415 @default.
• W3118507382 cites W2081840941 @default.
• W3118507382 cites W2084002035 @default.
• W3118507382 cites W2094972344 @default.
• W3118507382 cites W2096152863 @default.
• W3118507382 cites W2098976753 @default.
• W3118507382 cites W2099261151 @default.
• W3118507382 cites W2110676296 @default.
• W3118507382 cites W2111860362 @default.
• W3118507382 cites W2114037935 @default.
• W3118507382 cites W2131647194 @default.
• W3118507382 cites W2146226755 @default.
• W3118507382 cites W2152642587 @default.
• W3118507382 cites W2164074199 @default.
• W3118507382 cites W2168400988 @default.
• W3118507382 cites W2242046211 @default.
• W3118507382 cites W2253581382 @default.
• W3118507382 cites W2335127767 @default.
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• W3118507382 cites W2607364818 @default.
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• W3118507382 doi "https://doi.org/10.1186/s12967-020-02615-2" @default.
• W3118507382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7788785" @default.
• W3118507382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33407530" @default.
• W3118507382 hasPublicationYear "2021" @default.
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