FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118542260> ?p ?o ?g. }

• W3118542260 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease (COVID-19) which has recently emerged as a potential threat to global public health. SARS-CoV-2 is the third known human coronavirus that has huge impact on the human population after SARS-CoV and MERS-CoV. Although some vaccines and therapeutic drugs are currently in clinical trials, none of them are approved for commercial use yet. As with SARS-CoV, SARS-CoV-2 utilizes angiotensin-converting enzyme 2 (ACE2) as the cell entry receptor to enter into the host cell. In this study, we have transiently produced human ACE2 fused with the Fc region of human IgG1 in Nicotiana benthamiana and the in vitro neutralization efficacy of the plant-produced ACE2-Fc fusion protein was assessed. The recombinant ACE2-Fc fusion protein was expressed in N. benthamiana at 100 μg/g leaf fresh weight on day 6 post-infiltration. The recombinant fusion protein showed potent binding to receptor binding domain (RBD) of SARS-CoV-2. Importantly, the plant-produced fusion protein exhibited potent anti-SARS-CoV-2 activity in vitro . Treatment with ACE2-Fc fusion protein after viral infection dramatically inhibit SARS-CoV-2 infectivity in Vero cells with an IC 50 value of 0.84 μg/ml. Moreover, treatment with ACE2-Fc fusion protein at the pre-entry stage suppressed SARS-CoV-2 infection with an IC 50 of 94.66 μg/ml. These findings put a spotlight on the plant-produced ACE2-Fc fusion protein as a potential therapeutic candidate against SARS-CoV-2." @default.
• W3118542260 created "2021-01-18" @default.
• W3118542260 creator A5016081392 @default.
• W3118542260 creator A5021269330 @default.
• W3118542260 creator A5023102968 @default.
• W3118542260 creator A5024744454 @default.
• W3118542260 creator A5027042022 @default.
• W3118542260 creator A5040378824 @default.
• W3118542260 creator A5049878186 @default.
• W3118542260 creator A5058705683 @default.
• W3118542260 creator A5065894996 @default.
• W3118542260 creator A5068973023 @default.
• W3118542260 date "2021-01-07" @default.
• W3118542260 modified "2023-10-05" @default.
• W3118542260 title "Development of Plant-Produced Recombinant ACE2-Fc Fusion Protein as a Potential Therapeutic Agent Against SARS-CoV-2" @default.
• W3118542260 cites W1544561280 @default.
• W3118542260 cites W1964982019 @default.
• W3118542260 cites W1965435260 @default.
• W3118542260 cites W1966238900 @default.
• W3118542260 cites W1968800426 @default.
• W3118542260 cites W1976617934 @default.
• W3118542260 cites W1981256679 @default.
• W3118542260 cites W1982533785 @default.
• W3118542260 cites W2009052421 @default.
• W3118542260 cites W2013327564 @default.
• W3118542260 cites W2015554071 @default.
• W3118542260 cites W2023835210 @default.
• W3118542260 cites W2025629542 @default.
• W3118542260 cites W2025939977 @default.
• W3118542260 cites W2033190476 @default.
• W3118542260 cites W2054228154 @default.
• W3118542260 cites W2091671824 @default.
• W3118542260 cites W2094530716 @default.
• W3118542260 cites W2096758348 @default.
• W3118542260 cites W2114638149 @default.
• W3118542260 cites W2121386372 @default.
• W3118542260 cites W2123959544 @default.
• W3118542260 cites W2125697196 @default.
• W3118542260 cites W2133723912 @default.
• W3118542260 cites W2138361815 @default.
• W3118542260 cites W2138906847 @default.
• W3118542260 cites W2141247392 @default.
• W3118542260 cites W2141570973 @default.
• W3118542260 cites W2145849674 @default.
• W3118542260 cites W2146476111 @default.
• W3118542260 cites W2161150359 @default.
• W3118542260 cites W2164321625 @default.
• W3118542260 cites W2166771922 @default.
• W3118542260 cites W2166971565 @default.
• W3118542260 cites W2167381455 @default.
• W3118542260 cites W2167384912 @default.
• W3118542260 cites W2189310977 @default.
• W3118542260 cites W2409640005 @default.
• W3118542260 cites W2419274037 @default.
• W3118542260 cites W2466982071 @default.
• W3118542260 cites W2560447133 @default.
• W3118542260 cites W2586724023 @default.
• W3118542260 cites W2593542946 @default.
• W3118542260 cites W2802659015 @default.
• W3118542260 cites W2912449970 @default.
• W3118542260 cites W2990803441 @default.
• W3118542260 cites W2991037039 @default.
• W3118542260 cites W3003668884 @default.
• W3118542260 cites W3004071935 @default.
• W3118542260 cites W3004280078 @default.
• W3118542260 cites W3006703916 @default.
• W3118542260 cites W3007626557 @default.
• W3118542260 cites W3007933225 @default.
• W3118542260 cites W3009654169 @default.
• W3118542260 cites W3009932851 @default.
• W3118542260 cites W3010126769 @default.
• W3118542260 cites W3011959119 @default.
• W3118542260 cites W3013348202 @default.
• W3118542260 cites W3014426942 @default.
• W3118542260 cites W3015003375 @default.
• W3118542260 cites W3015371627 @default.
• W3118542260 cites W3016137283 @default.
• W3118542260 cites W3016473145 @default.
• W3118542260 cites W3017779455 @default.
• W3118542260 cites W3017850114 @default.
• W3118542260 cites W3019663170 @default.
• W3118542260 cites W3025162994 @default.
• W3118542260 cites W3033349936 @default.
• W3118542260 doi "https://doi.org/10.3389/fpls.2020.604663" @default.
• W3118542260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7874119" @default.
• W3118542260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33584747" @default.
• W3118542260 hasPublicationYear "2021" @default.
• W3118542260 type Work @default.
• W3118542260 sameAs 3118542260 @default.
• W3118542260 citedByCount "31" @default.
• W3118542260 countsByYear W31185422602021 @default.
• W3118542260 countsByYear W31185422602022 @default.
• W3118542260 countsByYear W31185422602023 @default.
• W3118542260 crossrefType "journal-article" @default.
• W3118542260 hasAuthorship W3118542260A5016081392 @default.
• W3118542260 hasAuthorship W3118542260A5021269330 @default.
• W3118542260 hasAuthorship W3118542260A5023102968 @default.
• W3118542260 hasAuthorship W3118542260A5024744454 @default.
• W3118542260 hasAuthorship W3118542260A5027042022 @default.
• W3118542260 hasAuthorship W3118542260A5040378824 @default.

• next