Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118552924> ?p ?o ?g. }
- W3118552924 endingPage "1896" @default.
- W3118552924 startingPage "1882" @default.
- W3118552924 abstract "Adults are more likely to suffer from chronic pain than minors, and its underlying mechanism remains unclear. SIRT1 an important age-related protein with function of lifespan extension; whether SIRT1 plays a role in the different pain vulnerability of adult and juvenile remains unclear. Here, we found that the expression level of SIRT1 in dorsal root ganglia (DRG) was related to the pain vulnerability. After nerve injury, the expression of SIRT1 in DRG was decreased in adult rodents whereas increased in juvenile rodents. Differential manipulation of SIRT1 abolished the different pain vulnerability between adult and juvenile rodents. Furthermore, SIRT1 interacted with ClC-3 channel and mediated ClC-3 membrane trafficking and Cl- current in DRG neurons. Differential manipulation of ClC-3 also abolished the difference in pain vulnerability between adult and juvenile rodents. The different anti-inflammatory ability determined the different change trends of SIRT1 and ClC-3 trafficking contributed to the different pain vulnerability in adult and juvenile rodents. In addition, the serum SIRT1 level was negatively correlated with the pain score in patients with chronic pain. These findings revealed the mechanism of the difference in pain vulnerability between adult and juvenile rodents and provided evidence for age-specific treatment of chronic pain." @default.
- W3118552924 created "2021-01-18" @default.
- W3118552924 creator A5016509155 @default.
- W3118552924 creator A5022952042 @default.
- W3118552924 creator A5025713623 @default.
- W3118552924 creator A5026225105 @default.
- W3118552924 creator A5028141611 @default.
- W3118552924 creator A5045925603 @default.
- W3118552924 creator A5048918848 @default.
- W3118552924 creator A5070538645 @default.
- W3118552924 creator A5070999349 @default.
- W3118552924 date "2021-01-05" @default.
- W3118552924 modified "2023-10-14" @default.
- W3118552924 title "Difference of pain vulnerability in adult and juvenile rodents: the role of SIRT1-mediated ClC-3 trafficking in sensory neurons" @default.
- W3118552924 cites W1440648612 @default.
- W3118552924 cites W1980353756 @default.
- W3118552924 cites W1981546597 @default.
- W3118552924 cites W1985802000 @default.
- W3118552924 cites W1988768211 @default.
- W3118552924 cites W1999834026 @default.
- W3118552924 cites W2009740794 @default.
- W3118552924 cites W2017462460 @default.
- W3118552924 cites W2035605437 @default.
- W3118552924 cites W2042707882 @default.
- W3118552924 cites W2046728004 @default.
- W3118552924 cites W2047010161 @default.
- W3118552924 cites W2050293532 @default.
- W3118552924 cites W2071653080 @default.
- W3118552924 cites W2075043109 @default.
- W3118552924 cites W2083095159 @default.
- W3118552924 cites W2097948853 @default.
- W3118552924 cites W2098190102 @default.
- W3118552924 cites W2098432330 @default.
- W3118552924 cites W2114805652 @default.
- W3118552924 cites W2124898423 @default.
- W3118552924 cites W2125121177 @default.
- W3118552924 cites W2138809708 @default.
- W3118552924 cites W2143527146 @default.
- W3118552924 cites W2149079606 @default.
- W3118552924 cites W2154587590 @default.
- W3118552924 cites W2159332152 @default.
- W3118552924 cites W2162362319 @default.
- W3118552924 cites W2504860466 @default.
- W3118552924 cites W2533290068 @default.
- W3118552924 cites W2541434109 @default.
- W3118552924 cites W2562335395 @default.
- W3118552924 cites W2588609998 @default.
- W3118552924 cites W2588928653 @default.
- W3118552924 cites W2605480835 @default.
- W3118552924 cites W2742156795 @default.
- W3118552924 cites W2765574238 @default.
- W3118552924 cites W2790175420 @default.
- W3118552924 cites W2794489806 @default.
- W3118552924 cites W2795803493 @default.
- W3118552924 cites W2803933977 @default.
- W3118552924 cites W2805997389 @default.
- W3118552924 cites W2891660975 @default.
- W3118552924 cites W2897399234 @default.
- W3118552924 cites W2909148913 @default.
- W3118552924 cites W2910933675 @default.
- W3118552924 cites W2944592785 @default.
- W3118552924 cites W2968762275 @default.
- W3118552924 cites W2986437494 @default.
- W3118552924 cites W3006898855 @default.
- W3118552924 doi "https://doi.org/10.1097/j.pain.0000000000002176" @default.
- W3118552924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33433144" @default.
- W3118552924 hasPublicationYear "2021" @default.
- W3118552924 type Work @default.
- W3118552924 sameAs 3118552924 @default.
- W3118552924 citedByCount "5" @default.
- W3118552924 countsByYear W31185529242021 @default.
- W3118552924 countsByYear W31185529242022 @default.
- W3118552924 countsByYear W31185529242023 @default.
- W3118552924 crossrefType "journal-article" @default.
- W3118552924 hasAuthorship W3118552924A5016509155 @default.
- W3118552924 hasAuthorship W3118552924A5022952042 @default.
- W3118552924 hasAuthorship W3118552924A5025713623 @default.
- W3118552924 hasAuthorship W3118552924A5026225105 @default.
- W3118552924 hasAuthorship W3118552924A5028141611 @default.
- W3118552924 hasAuthorship W3118552924A5045925603 @default.
- W3118552924 hasAuthorship W3118552924A5048918848 @default.
- W3118552924 hasAuthorship W3118552924A5070538645 @default.
- W3118552924 hasAuthorship W3118552924A5070999349 @default.
- W3118552924 hasConcept C115961737 @default.
- W3118552924 hasConcept C126322002 @default.
- W3118552924 hasConcept C169760540 @default.
- W3118552924 hasConcept C2776281502 @default.
- W3118552924 hasConcept C2781118164 @default.
- W3118552924 hasConcept C2992926266 @default.
- W3118552924 hasConcept C38652104 @default.
- W3118552924 hasConcept C41008148 @default.
- W3118552924 hasConcept C54355233 @default.
- W3118552924 hasConcept C71924100 @default.
- W3118552924 hasConcept C86803240 @default.
- W3118552924 hasConcept C94487597 @default.
- W3118552924 hasConcept C95713431 @default.
- W3118552924 hasConceptScore W3118552924C115961737 @default.
- W3118552924 hasConceptScore W3118552924C126322002 @default.