FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118555687> ?p ?o ?g. }

• W3118555687 endingPage "56" @default.
• W3118555687 startingPage "51" @default.
• W3118555687 abstract "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic. The angiotensin-converting enzyme 2 (ACE2) has been proven to be used by SARS-CoV-2 for host cell entry. Considering that angiotensin receptor blockers and ACE inhibitors (ACEIs) upregulate the expression of ACE2 in animal studies, there may be a concern about whether these drugs may increase COVID-19 susceptibility and severity. Recently, there has been a debate among clinicians about whether to continue or to stop ACEIs and angiotensin receptor blockers in the context of COVID-19. Also, some media outlets and health systems have called for the discontinuation of these drugs in the context of suspected COVID-19. This has necessitated an urgent release of guidance on the use of such medications in COVID-19 patients. To date, multiple theories relating to the pure effects of renin-angiotensin-aldosterone system (RAAS) inhibitors on COVID-19 infections have been postulated. Favorable effects include blocking the ACE2 receptors, preventing viral entry into the heart and lungs, and protecting against lung injury in COVID-19. Adverse effects include a possible retrograde feedback mechanism that upregulates ACE2 receptors. This review provides greater insight into the role of the RAAS axis in acute lung injury and the effects of RAAS inhibitors on SARS-CoVs. The hypothesis that RAAS inhibitors facilitate viral insertion and the alternative hypothesis of the beneficial role of these drugs are discussed. Up-to-date published data concerning the RAAS inhibitors and COVID-19 are summarized." @default.
• W3118555687 created "2021-01-18" @default.
• W3118555687 creator A5035180475 @default.
• W3118555687 date "2021-01-01" @default.
• W3118555687 modified "2023-09-30" @default.
• W3118555687 title "Renin-Angiotensin-Aldosterone System (RAAS) Inhibitors and Coronavirus Disease 2019 (COVID-19)" @default.
• W3118555687 cites W1964982019 @default.
• W3118555687 cites W1978525739 @default.
• W3118555687 cites W1983428551 @default.
• W3118555687 cites W2002765492 @default.
• W3118555687 cites W2003471175 @default.
• W3118555687 cites W2028521865 @default.
• W3118555687 cites W2037033420 @default.
• W3118555687 cites W2043757786 @default.
• W3118555687 cites W2054902365 @default.
• W3118555687 cites W2055306864 @default.
• W3118555687 cites W2091671824 @default.
• W3118555687 cites W2093449144 @default.
• W3118555687 cites W2123906295 @default.
• W3118555687 cites W2125943457 @default.
• W3118555687 cites W2144370633 @default.
• W3118555687 cites W2152329221 @default.
• W3118555687 cites W2159560438 @default.
• W3118555687 cites W2773619306 @default.
• W3118555687 cites W2780715796 @default.
• W3118555687 cites W2807942438 @default.
• W3118555687 cites W2947642275 @default.
• W3118555687 cites W2979853831 @default.
• W3118555687 cites W2994488898 @default.
• W3118555687 cites W3001118548 @default.
• W3118555687 cites W3004280078 @default.
• W3118555687 cites W3005655936 @default.
• W3118555687 cites W3007814559 @default.
• W3118555687 cites W3008028633 @default.
• W3118555687 cites W3008827533 @default.
• W3118555687 cites W3009885589 @default.
• W3118555687 cites W3013921190 @default.
• W3118555687 cites W3016010853 @default.
• W3118555687 cites W3016572296 @default.
• W3118555687 cites W3023640683 @default.
• W3118555687 cites W3023751598 @default.
• W3118555687 cites W3023826646 @default.
• W3118555687 cites W3025099648 @default.
• W3118555687 cites W3026112706 @default.
• W3118555687 doi "https://doi.org/10.14423/smj.0000000000001200" @default.
• W3118555687 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7769064" @default.
• W3118555687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33398362" @default.
• W3118555687 hasPublicationYear "2021" @default.
• W3118555687 type Work @default.
• W3118555687 sameAs 3118555687 @default.
• W3118555687 citedByCount "14" @default.
• W3118555687 countsByYear W31185556872021 @default.
• W3118555687 countsByYear W31185556872022 @default.
• W3118555687 countsByYear W31185556872023 @default.
• W3118555687 crossrefType "journal-article" @default.
• W3118555687 hasAuthorship W3118555687A5035180475 @default.
• W3118555687 hasBestOaLocation W31185556872 @default.
• W3118555687 hasConcept C116675565 @default.
• W3118555687 hasConcept C126322002 @default.
• W3118555687 hasConcept C159047783 @default.
• W3118555687 hasConcept C198710026 @default.
• W3118555687 hasConcept C2775946041 @default.
• W3118555687 hasConcept C2777648638 @default.
• W3118555687 hasConcept C2778525890 @default.
• W3118555687 hasConcept C2779134260 @default.
• W3118555687 hasConcept C2910482119 @default.
• W3118555687 hasConcept C3006700255 @default.
• W3118555687 hasConcept C3007834351 @default.
• W3118555687 hasConcept C3008058167 @default.
• W3118555687 hasConcept C524204448 @default.
• W3118555687 hasConcept C71924100 @default.
• W3118555687 hasConcept C84393581 @default.
• W3118555687 hasConcept C98274493 @default.
• W3118555687 hasConceptScore W3118555687C116675565 @default.
• W3118555687 hasConceptScore W3118555687C126322002 @default.
• W3118555687 hasConceptScore W3118555687C159047783 @default.
• W3118555687 hasConceptScore W3118555687C198710026 @default.
• W3118555687 hasConceptScore W3118555687C2775946041 @default.
• W3118555687 hasConceptScore W3118555687C2777648638 @default.
• W3118555687 hasConceptScore W3118555687C2778525890 @default.
• W3118555687 hasConceptScore W3118555687C2779134260 @default.
• W3118555687 hasConceptScore W3118555687C2910482119 @default.
• W3118555687 hasConceptScore W3118555687C3006700255 @default.
• W3118555687 hasConceptScore W3118555687C3007834351 @default.
• W3118555687 hasConceptScore W3118555687C3008058167 @default.
• W3118555687 hasConceptScore W3118555687C524204448 @default.
• W3118555687 hasConceptScore W3118555687C71924100 @default.
• W3118555687 hasConceptScore W3118555687C84393581 @default.
• W3118555687 hasConceptScore W3118555687C98274493 @default.
• W3118555687 hasIssue "1" @default.
• W3118555687 hasLocation W31185556871 @default.
• W3118555687 hasLocation W31185556872 @default.
• W3118555687 hasLocation W31185556873 @default.
• W3118555687 hasOpenAccess W3118555687 @default.
• W3118555687 hasPrimaryLocation W31185556871 @default.
• W3118555687 hasRelatedWork W3007986422 @default.
• W3118555687 hasRelatedWork W3013171238 @default.
• W3118555687 hasRelatedWork W3020699490 @default.

• next