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• W3118562156 abstract "Abstract In the present study, we demonstrate the coaction of thioredoxin and glutathione (GSH) systems in mouse liver against iron overload‐induced oxidative stress (OS). Mice were injected intraperitoneally with an iron dextran solution twice a week for 3 weeks. Iron accumulation in mouse liver was demonstrated spectroscopically. To confirm the iron overload model in the liver, the increased gene expression levels of hepcidin ( Hamp ), ferroportin ( Fpn1 ), and ferritin ( Fth1 ), which regulate iron trafficking, were observed by a quantitative polymerase chain reaction. In the case of iron overload, the GSH level and the reduced glutathione/oxidized glutathione ratio, which represents a marker of OS, decreased significantly. An increase in the malondialdehyde level, one of the final products of the lipid peroxidation process, was observed. The gene expression of the thioredoxin system, including thioredoxin ( Trx1 ) and thioredoxin reductase ( TrxR1 ), was examined. Though TrxR1 expression decreased, no changes were observed in Trx1 . The enzyme activity and semiquantitative protein expression of TRXR1 increased. The activity of GSH reductase and GSH peroxidase increased in the iron overload group. The gene and protein expressions of thioredoxininteracting protein, which is an indicator of the commitment of the cell to apoptosis, were elevated significantly. The increased protein expression of Bcl‐2‐related X protein and CASPASE‐3, which is an indicator of apoptosis, increased significantly. In conclusion, excess iron accumulation in mouse liver tissue causes OS, which affects the redox state of the thioredoxin and GSH systems, inducing cell apoptosis and also ferroptosis due to increased lipid peroxidation and the depletion of GSH level." @default.
• W3118562156 created "2021-01-18" @default.
• W3118562156 creator A5008589264 @default.
• W3118562156 creator A5044153414 @default.
• W3118562156 creator A5075297645 @default.
• W3118562156 date "2021-01-03" @default.
• W3118562156 modified "2023-10-18" @default.
• W3118562156 title "Coaction of hepatic thioredoxin and glutathione systems in iron overload‐induced oxidative stress" @default.
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• W3118562156 cites W1977849940 @default.
• W3118562156 cites W1978772332 @default.
• W3118562156 cites W1983310681 @default.
• W3118562156 cites W1988734169 @default.
• W3118562156 cites W1989628365 @default.
• W3118562156 cites W1992900987 @default.
• W3118562156 cites W1997183854 @default.
• W3118562156 cites W2002239849 @default.
• W3118562156 cites W2015031752 @default.
• W3118562156 cites W2021143006 @default.
• W3118562156 cites W2028034405 @default.
• W3118562156 cites W2029342214 @default.
• W3118562156 cites W2033353801 @default.
• W3118562156 cites W2033465391 @default.
• W3118562156 cites W2034902084 @default.
• W3118562156 cites W2047326665 @default.
• W3118562156 cites W2050083026 @default.
• W3118562156 cites W2050276762 @default.
• W3118562156 cites W2059216373 @default.
• W3118562156 cites W2059778114 @default.
• W3118562156 cites W2061391275 @default.
• W3118562156 cites W2061565132 @default.
• W3118562156 cites W2063447619 @default.
• W3118562156 cites W2063487298 @default.
• W3118562156 cites W2068218660 @default.
• W3118562156 cites W2073703119 @default.
• W3118562156 cites W2075588775 @default.
• W3118562156 cites W2076748372 @default.
• W3118562156 cites W2086445948 @default.
• W3118562156 cites W2094776609 @default.
• W3118562156 cites W2096056489 @default.
• W3118562156 cites W2100837269 @default.
• W3118562156 cites W2101108802 @default.
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• W3118562156 cites W2107704801 @default.
• W3118562156 cites W2110942523 @default.
• W3118562156 cites W2112867510 @default.
• W3118562156 cites W2115629004 @default.
• W3118562156 cites W2118519973 @default.
• W3118562156 cites W2122513194 @default.
• W3118562156 cites W2123098050 @default.
• W3118562156 cites W2123130100 @default.
• W3118562156 cites W2125289626 @default.
• W3118562156 cites W2125628477 @default.
• W3118562156 cites W2132403739 @default.
• W3118562156 cites W2133639113 @default.
• W3118562156 cites W2140665078 @default.
• W3118562156 cites W2150887163 @default.
• W3118562156 cites W2153145418 @default.
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• W3118562156 cites W2167450976 @default.
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• W3118562156 cites W2189205651 @default.
• W3118562156 cites W2344775600 @default.
• W3118562156 cites W2346078141 @default.
• W3118562156 cites W2580415908 @default.
• W3118562156 cites W2584260978 @default.
• W3118562156 cites W2621042041 @default.
• W3118562156 cites W2709224048 @default.
• W3118562156 cites W2766930181 @default.
• W3118562156 cites W2789556356 @default.
• W3118562156 cites W2870351107 @default.
• W3118562156 cites W2883979293 @default.
• W3118562156 cites W2888091897 @default.
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• W3118562156 cites W2951027422 @default.
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• W3118562156 cites W2989980593 @default.
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• W3118562156 doi "https://doi.org/10.1002/jbt.22704" @default.
• W3118562156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33393188" @default.
• W3118562156 hasPublicationYear "2021" @default.
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