Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118577024> ?p ?o ?g. }
- W3118577024 abstract "Abstract Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc patients and 92 age-/sex-matched healthy controls were recruited for the cross-sectional analysis. The longitudinal analysis comprised 30 patients with SSc associated interstitial lung disease (ILD) routinely treated with cyclophosphamide. Hsp90 was increased in SSc compared to healthy controls. Hsp90 correlated positively with C-reactive protein and negatively with pulmonary function tests: forced vital capacity and diffusing capacity for carbon monoxide (DLCO). In patients with diffuse cutaneous (dc) SSc, Hsp90 positively correlated with the modified Rodnan skin score. In SSc-ILD patients treated with cyclophosphamide, no differences in Hsp90 were found between baseline and after 1, 6, or 12 months of therapy. However, baseline Hsp90 predicts the 12-month change in DLCO. This study shows that Hsp90 plasma levels are increased in SSc patients compared to age-/sex-matched healthy controls. Elevated Hsp90 in SSc is associated with increased inflammatory activity, worse lung functions, and in dcSSc, with the extent of skin involvement. Baseline plasma Hsp90 predicts the 12-month change in DLCO in SSc-ILD patients treated with cyclophosphamide." @default.
- W3118577024 created "2021-01-18" @default.
- W3118577024 creator A5019621028 @default.
- W3118577024 creator A5031588644 @default.
- W3118577024 creator A5032641681 @default.
- W3118577024 creator A5057948163 @default.
- W3118577024 creator A5059312680 @default.
- W3118577024 creator A5062096932 @default.
- W3118577024 creator A5064499724 @default.
- W3118577024 creator A5068642197 @default.
- W3118577024 creator A5069564967 @default.
- W3118577024 creator A5076848079 @default.
- W3118577024 creator A5079921904 @default.
- W3118577024 creator A5089477356 @default.
- W3118577024 date "2021-01-07" @default.
- W3118577024 modified "2023-10-18" @default.
- W3118577024 title "Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study" @default.
- W3118577024 cites W1549404046 @default.
- W3118577024 cites W178900729 @default.
- W3118577024 cites W1965586395 @default.
- W3118577024 cites W1970190279 @default.
- W3118577024 cites W2002044132 @default.
- W3118577024 cites W2037658248 @default.
- W3118577024 cites W2044225151 @default.
- W3118577024 cites W2044304089 @default.
- W3118577024 cites W2046329541 @default.
- W3118577024 cites W2055198492 @default.
- W3118577024 cites W2074353479 @default.
- W3118577024 cites W2083485692 @default.
- W3118577024 cites W2086518433 @default.
- W3118577024 cites W2088929311 @default.
- W3118577024 cites W2103533975 @default.
- W3118577024 cites W2104061566 @default.
- W3118577024 cites W2104755183 @default.
- W3118577024 cites W2126228008 @default.
- W3118577024 cites W2132919995 @default.
- W3118577024 cites W2137417707 @default.
- W3118577024 cites W2144562554 @default.
- W3118577024 cites W2157261840 @default.
- W3118577024 cites W2165812090 @default.
- W3118577024 cites W2347093301 @default.
- W3118577024 cites W2508060872 @default.
- W3118577024 cites W2519768493 @default.
- W3118577024 cites W2586979555 @default.
- W3118577024 cites W2588889117 @default.
- W3118577024 cites W2604596332 @default.
- W3118577024 cites W2736363887 @default.
- W3118577024 cites W2772664042 @default.
- W3118577024 cites W2885354567 @default.
- W3118577024 cites W2898042272 @default.
- W3118577024 cites W2953044679 @default.
- W3118577024 cites W2985676661 @default.
- W3118577024 cites W2995067265 @default.
- W3118577024 cites W3000906987 @default.
- W3118577024 cites W3003765072 @default.
- W3118577024 cites W3008900858 @default.
- W3118577024 cites W3118785335 @default.
- W3118577024 cites W4211001791 @default.
- W3118577024 doi "https://doi.org/10.1038/s41598-020-79139-8" @default.
- W3118577024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7791137" @default.
- W3118577024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33414495" @default.
- W3118577024 hasPublicationYear "2021" @default.
- W3118577024 type Work @default.
- W3118577024 sameAs 3118577024 @default.
- W3118577024 citedByCount "3207" @default.
- W3118577024 countsByYear W31185770242020 @default.
- W3118577024 countsByYear W31185770242021 @default.
- W3118577024 countsByYear W31185770242022 @default.
- W3118577024 countsByYear W31185770242023 @default.
- W3118577024 crossrefType "journal-article" @default.
- W3118577024 hasAuthorship W3118577024A5019621028 @default.
- W3118577024 hasAuthorship W3118577024A5031588644 @default.
- W3118577024 hasAuthorship W3118577024A5032641681 @default.
- W3118577024 hasAuthorship W3118577024A5057948163 @default.
- W3118577024 hasAuthorship W3118577024A5059312680 @default.
- W3118577024 hasAuthorship W3118577024A5062096932 @default.
- W3118577024 hasAuthorship W3118577024A5064499724 @default.
- W3118577024 hasAuthorship W3118577024A5068642197 @default.
- W3118577024 hasAuthorship W3118577024A5069564967 @default.
- W3118577024 hasAuthorship W3118577024A5076848079 @default.
- W3118577024 hasAuthorship W3118577024A5079921904 @default.
- W3118577024 hasAuthorship W3118577024A5089477356 @default.
- W3118577024 hasBestOaLocation W31185770241 @default.
- W3118577024 hasConcept C104317684 @default.
- W3118577024 hasConcept C126322002 @default.
- W3118577024 hasConcept C142724271 @default.
- W3118577024 hasConcept C16020263 @default.
- W3118577024 hasConcept C165637977 @default.
- W3118577024 hasConcept C180032290 @default.
- W3118577024 hasConcept C185592680 @default.
- W3118577024 hasConcept C205260736 @default.
- W3118577024 hasConcept C2776694085 @default.
- W3118577024 hasConcept C2776755627 @default.
- W3118577024 hasConcept C2777543607 @default.
- W3118577024 hasConcept C2777714996 @default.
- W3118577024 hasConcept C2779967694 @default.
- W3118577024 hasConcept C3018587741 @default.
- W3118577024 hasConcept C55493867 @default.
- W3118577024 hasConcept C55520419 @default.
- W3118577024 hasConcept C71924100 @default.