Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118581844> ?p ?o ?g. }
- W3118581844 endingPage "253" @default.
- W3118581844 startingPage "253" @default.
- W3118581844 abstract "The increase in osteoporotic fracture worldwide is urging bone tissue engineering research to find new, improved solutions both for the biomaterials used in designing bone scaffolds and the anti-osteoporotic agents capable of promoting bone regeneration. This review aims to report on the latest advances in biomaterials by discussing the types of biomaterials and their properties, with a special emphasis on polymer-ceramic composites. The use of hydroxyapatite in combination with natural/synthetic polymers can take advantage of each of their components properties and has a great potential in bone tissue engineering, in general. A comparison between the benefits and potential limitations of different scaffold fabrication methods lead to a raised awareness of the challenges research face in dealing with osteoporotic fracture. Advances in 3D printing techniques are providing the ways to manufacture improved, complex, and specialized 3D scaffolds, capable of delivering therapeutic factors directly at the osteoporotic skeletal defect site with predefined rate which is essential in order to optimize the osteointegration/healing rate. Among these factors, strontium has the potential to increase osseointegration, osteogenesis, and healing rate. Strontium ranelate as well as other biological active agents are known to be effective in treating osteoporosis due to both anti-resorptive and anabolic properties but has adverse effects that can be reduced/avoided by local release from biomaterials. In this manner, incorporation of these agents in polymer-ceramic composites bone scaffolds can have significant clinical applications for the recovery of fractured osteoporotic bones limiting or removing the risks associated with systemic administration." @default.
- W3118581844 created "2021-01-18" @default.
- W3118581844 creator A5027685617 @default.
- W3118581844 creator A5034457432 @default.
- W3118581844 creator A5036236550 @default.
- W3118581844 creator A5043537694 @default.
- W3118581844 creator A5048757691 @default.
- W3118581844 creator A5074008413 @default.
- W3118581844 creator A5079490208 @default.
- W3118581844 date "2021-01-12" @default.
- W3118581844 modified "2023-09-29" @default.
- W3118581844 title "Advances in Osteoporotic Bone Tissue Engineering" @default.
- W3118581844 cites W1594571717 @default.
- W3118581844 cites W1712933411 @default.
- W3118581844 cites W1849561856 @default.
- W3118581844 cites W1953179980 @default.
- W3118581844 cites W1966316996 @default.
- W3118581844 cites W1975428589 @default.
- W3118581844 cites W1995457368 @default.
- W3118581844 cites W2004519235 @default.
- W3118581844 cites W2007310752 @default.
- W3118581844 cites W2014475515 @default.
- W3118581844 cites W2026182284 @default.
- W3118581844 cites W2030271406 @default.
- W3118581844 cites W2031453471 @default.
- W3118581844 cites W2035510401 @default.
- W3118581844 cites W2041698195 @default.
- W3118581844 cites W2041859989 @default.
- W3118581844 cites W2074226229 @default.
- W3118581844 cites W2078965438 @default.
- W3118581844 cites W2101601223 @default.
- W3118581844 cites W2111195311 @default.
- W3118581844 cites W2119062112 @default.
- W3118581844 cites W2138825667 @default.
- W3118581844 cites W2142186105 @default.
- W3118581844 cites W2142307201 @default.
- W3118581844 cites W2199555817 @default.
- W3118581844 cites W2251974878 @default.
- W3118581844 cites W2295283893 @default.
- W3118581844 cites W2324174124 @default.
- W3118581844 cites W2337959263 @default.
- W3118581844 cites W2338161109 @default.
- W3118581844 cites W23652341 @default.
- W3118581844 cites W2493288681 @default.
- W3118581844 cites W2524977260 @default.
- W3118581844 cites W2597343929 @default.
- W3118581844 cites W2623981860 @default.
- W3118581844 cites W2737721978 @default.
- W3118581844 cites W2740130472 @default.
- W3118581844 cites W2774085282 @default.
- W3118581844 cites W2777648965 @default.
- W3118581844 cites W2782698500 @default.
- W3118581844 cites W2795290522 @default.
- W3118581844 cites W2801339791 @default.
- W3118581844 cites W2807241802 @default.
- W3118581844 cites W2809635035 @default.
- W3118581844 cites W2885616936 @default.
- W3118581844 cites W2886564375 @default.
- W3118581844 cites W2886673382 @default.
- W3118581844 cites W2886738451 @default.
- W3118581844 cites W2886748148 @default.
- W3118581844 cites W2892361598 @default.
- W3118581844 cites W2900288115 @default.
- W3118581844 cites W2919748294 @default.
- W3118581844 cites W2923561240 @default.
- W3118581844 cites W2942762570 @default.
- W3118581844 cites W2953974367 @default.
- W3118581844 cites W2959863118 @default.
- W3118581844 cites W2967938005 @default.
- W3118581844 cites W2972756894 @default.
- W3118581844 cites W2982443409 @default.
- W3118581844 cites W2982895754 @default.
- W3118581844 cites W2988565835 @default.
- W3118581844 cites W2989628793 @default.
- W3118581844 cites W3004363918 @default.
- W3118581844 cites W3004519387 @default.
- W3118581844 cites W3004829929 @default.
- W3118581844 cites W3005414186 @default.
- W3118581844 cites W3006807222 @default.
- W3118581844 cites W3007721233 @default.
- W3118581844 cites W3010423607 @default.
- W3118581844 cites W3011063707 @default.
- W3118581844 cites W3012409677 @default.
- W3118581844 cites W3017058951 @default.
- W3118581844 cites W3022326811 @default.
- W3118581844 cites W3022938424 @default.
- W3118581844 cites W3027722086 @default.
- W3118581844 cites W3037517936 @default.
- W3118581844 cites W3042094028 @default.
- W3118581844 cites W3097268971 @default.
- W3118581844 cites W3106482867 @default.
- W3118581844 cites W3146228058 @default.
- W3118581844 cites W4210962793 @default.
- W3118581844 cites W4231405087 @default.
- W3118581844 cites W594995165 @default.
- W3118581844 cites W2887777513 @default.
- W3118581844 doi "https://doi.org/10.3390/jcm10020253" @default.
- W3118581844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7827332" @default.