Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118582685> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3118582685 endingPage "14" @default.
- W3118582685 startingPage "8" @default.
- W3118582685 abstract "The conventional notions of pseudogenes being ‘junk DNA’ have largely been offset as research studies have established their role in multiple biological processes. Our studies towards identification of genetic modulators employing C. elegans model, that associate reproductive health and age-related neurodegenerative diseases, led us to identification and functional characterization of a pseudogene T04B2.1, which when knocked down, exacerbates the aggregation of α-Synuclein and β-Amyloid proteins, induces lipid deposition and alters morphometric endpoints in worms. Whole transcriptome analysis of worms under knockdown condition of T04B2.1 revealed an altered expression of 187 sequences, most of these being non-coding RNAs, miRNAs and piRNAs modulating the RNAi regulatory processes. Our gene ontology and pathway enrichment analysis demonstrated the role of T04B2.1 in protein quality control, metabolic pathways and development. We further performed a signature motif search and successfully identified a common motif that is present between all piRNA and miRNA molecules, which are significantly altered upon T04B2.1 silencing. This study unveils the non-conventional regulatory role of pseudogene T04B2.1 with respect to effects associated with neurodegenerative diseases and encourages further studies to decipher the regulatory mechanism governed by pseudogenes." @default.
- W3118582685 created "2021-01-18" @default.
- W3118582685 creator A5027463081 @default.
- W3118582685 creator A5050235279 @default.
- W3118582685 creator A5074172532 @default.
- W3118582685 date "2021-02-01" @default.
- W3118582685 modified "2023-09-23" @default.
- W3118582685 title "Not a piece of junk anymore: Pseudogene T04B2.1 performs non-conventional regulatory role and modulates aggregation of α- synuclein and β-amyloid proteins in C. elegans" @default.
- W3118582685 cites W1709815505 @default.
- W3118582685 cites W1975396085 @default.
- W3118582685 cites W1992548377 @default.
- W3118582685 cites W1994538163 @default.
- W3118582685 cites W2002559713 @default.
- W3118582685 cites W2012383052 @default.
- W3118582685 cites W2015423672 @default.
- W3118582685 cites W2068773764 @default.
- W3118582685 cites W2076260070 @default.
- W3118582685 cites W2091591117 @default.
- W3118582685 cites W2128491398 @default.
- W3118582685 cites W2138910750 @default.
- W3118582685 cites W2156008341 @default.
- W3118582685 cites W2161076846 @default.
- W3118582685 cites W2162558393 @default.
- W3118582685 cites W2163485494 @default.
- W3118582685 cites W2165503155 @default.
- W3118582685 cites W2169456326 @default.
- W3118582685 cites W2179438025 @default.
- W3118582685 cites W2755307222 @default.
- W3118582685 cites W2898280147 @default.
- W3118582685 cites W2898731714 @default.
- W3118582685 cites W2992652960 @default.
- W3118582685 cites W4294214907 @default.
- W3118582685 doi "https://doi.org/10.1016/j.bbrc.2020.12.029" @default.
- W3118582685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33412418" @default.
- W3118582685 hasPublicationYear "2021" @default.
- W3118582685 type Work @default.
- W3118582685 sameAs 3118582685 @default.
- W3118582685 citedByCount "2" @default.
- W3118582685 countsByYear W31185826852022 @default.
- W3118582685 countsByYear W31185826852023 @default.
- W3118582685 crossrefType "journal-article" @default.
- W3118582685 hasAuthorship W3118582685A5027463081 @default.
- W3118582685 hasAuthorship W3118582685A5050235279 @default.
- W3118582685 hasAuthorship W3118582685A5074172532 @default.
- W3118582685 hasConcept C104317684 @default.
- W3118582685 hasConcept C119056186 @default.
- W3118582685 hasConcept C141231307 @default.
- W3118582685 hasConcept C147724379 @default.
- W3118582685 hasConcept C150194340 @default.
- W3118582685 hasConcept C162317418 @default.
- W3118582685 hasConcept C166703698 @default.
- W3118582685 hasConcept C173396325 @default.
- W3118582685 hasConcept C2778944004 @default.
- W3118582685 hasConcept C34957205 @default.
- W3118582685 hasConcept C54355233 @default.
- W3118582685 hasConcept C67705224 @default.
- W3118582685 hasConcept C70721500 @default.
- W3118582685 hasConcept C86803240 @default.
- W3118582685 hasConcept C95444343 @default.
- W3118582685 hasConceptScore W3118582685C104317684 @default.
- W3118582685 hasConceptScore W3118582685C119056186 @default.
- W3118582685 hasConceptScore W3118582685C141231307 @default.
- W3118582685 hasConceptScore W3118582685C147724379 @default.
- W3118582685 hasConceptScore W3118582685C150194340 @default.
- W3118582685 hasConceptScore W3118582685C162317418 @default.
- W3118582685 hasConceptScore W3118582685C166703698 @default.
- W3118582685 hasConceptScore W3118582685C173396325 @default.
- W3118582685 hasConceptScore W3118582685C2778944004 @default.
- W3118582685 hasConceptScore W3118582685C34957205 @default.
- W3118582685 hasConceptScore W3118582685C54355233 @default.
- W3118582685 hasConceptScore W3118582685C67705224 @default.
- W3118582685 hasConceptScore W3118582685C70721500 @default.
- W3118582685 hasConceptScore W3118582685C86803240 @default.
- W3118582685 hasConceptScore W3118582685C95444343 @default.
- W3118582685 hasFunder F4320320767 @default.
- W3118582685 hasLocation W31185826851 @default.
- W3118582685 hasOpenAccess W3118582685 @default.
- W3118582685 hasPrimaryLocation W31185826851 @default.
- W3118582685 hasRelatedWork W1816943760 @default.
- W3118582685 hasRelatedWork W1861196385 @default.
- W3118582685 hasRelatedWork W2026561311 @default.
- W3118582685 hasRelatedWork W2063775754 @default.
- W3118582685 hasRelatedWork W2087274128 @default.
- W3118582685 hasRelatedWork W2135802673 @default.
- W3118582685 hasRelatedWork W2141084979 @default.
- W3118582685 hasRelatedWork W2508597590 @default.
- W3118582685 hasRelatedWork W3081138180 @default.
- W3118582685 hasRelatedWork W4200083385 @default.
- W3118582685 hasVolume "539" @default.
- W3118582685 isParatext "false" @default.
- W3118582685 isRetracted "false" @default.
- W3118582685 magId "3118582685" @default.
- W3118582685 workType "article" @default.