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• W3118584668 abstract "We report herein the discovery of a positron emission tomography (PET) tracer for the (NOD)-like receptor protein 3 (NLRP3). Our recent medicinal chemistry campaign on developing sulfonamide-based NLRP3 inhibitors led to an analog, 1, with a methoxy substituent amenable to labeling with carbon-11. PET/CT imaging studies indicated that [11C]1 exhibited rapid blood-brain barrier (BBB) penetration and moderate brain uptake, as well as blockable uptake in the brain. [11C]1, thus suggesting the potential to serve as a useful tool for imaging NLRP3 inflammasome in living brains." @default.
• W3118584668 created "2021-01-18" @default.
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• W3118584668 date "2021-02-01" @default.
• W3118584668 modified "2023-10-12" @default.
• W3118584668 title "Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome" @default.
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• W3118584668 doi "https://doi.org/10.1016/j.bmcl.2021.127777" @default.
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