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• W3118645466 abstract "Abstract Background Randomization is the foundation of any clinical trial involving treatment comparison. It helps mitigate selection bias, promotes similarity of treatment groups with respect to important known and unknown confounders, and contributes to the validity of statistical tests. Various restricted randomization procedures with different probabilistic structures and different statistical properties are available. The goal of this paper is to present a systematic roadmap for the choice and application of a restricted randomization procedure in a clinical trial. Methods We survey available restricted randomization procedures for sequential allocation of subjects in a randomized, comparative, parallel group clinical trial with equal (1:1) allocation. We explore statistical properties of these procedures, including balance/randomness tradeoff, type I error rate and power. We perform head-to-head comparisons of different procedures through simulation under various experimental scenarios, including cases when common model assumptions are violated. We also provide some real-life clinical trial examples to illustrate the thinking process for selecting a randomization procedure for implementation in practice. Results Restricted randomization procedures targeting 1:1 allocation vary in the degree of balance/randomness they induce, and more importantly, they vary in terms of validity and efficiency of statistical inference when common model assumptions are violated (e.g. when outcomes are affected by a linear time trend; measurement error distribution is misspecified; or selection bias is introduced in the experiment). Some procedures are more robust than others. Covariate-adjusted analysis may be essential to ensure validity of the results. Special considerations are required when selecting a randomization procedure for a clinical trial with very small sample size. Conclusions The choice of randomization design, data analytic technique (parametric or nonparametric), and analysis strategy (randomization-based or population model-based) are all very important considerations. Randomization-based tests are robust and valid alternatives to likelihood-based tests and should be considered more frequently by clinical investigators." @default.
• W3118645466 created "2021-01-18" @default.
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• W3118645466 date "2021-08-16" @default.
• W3118645466 modified "2023-10-06" @default.
• W3118645466 title "A roadmap to using randomization in clinical trials" @default.
• W3118645466 cites W105627024 @default.
• W3118645466 cites W1626634199 @default.
• W3118645466 cites W1827191207 @default.
• W3118645466 cites W1922493017 @default.
• W3118645466 cites W1964933824 @default.
• W3118645466 cites W1967848210 @default.
• W3118645466 cites W1969237525 @default.
• W3118645466 cites W1973574532 @default.
• W3118645466 cites W1982461541 @default.
• W3118645466 cites W1984899636 @default.
• W3118645466 cites W1985444897 @default.
• W3118645466 cites W1991058132 @default.
• W3118645466 cites W1996711428 @default.
• W3118645466 cites W1996795378 @default.
• W3118645466 cites W2000366267 @default.
• W3118645466 cites W2001203833 @default.
• W3118645466 cites W2005415125 @default.
• W3118645466 cites W2007316542 @default.
• W3118645466 cites W2012404408 @default.
• W3118645466 cites W2017329532 @default.
• W3118645466 cites W2025612029 @default.
• W3118645466 cites W2028021641 @default.
• W3118645466 cites W2028418359 @default.
• W3118645466 cites W2028894296 @default.
• W3118645466 cites W2031037217 @default.
• W3118645466 cites W2041801117 @default.
• W3118645466 cites W2042355708 @default.
• W3118645466 cites W2047311731 @default.
• W3118645466 cites W2057002358 @default.
• W3118645466 cites W2066452432 @default.
• W3118645466 cites W2069386303 @default.
• W3118645466 cites W2074407985 @default.
• W3118645466 cites W2075487640 @default.
• W3118645466 cites W2076302145 @default.
• W3118645466 cites W2077747785 @default.
• W3118645466 cites W2080083219 @default.
• W3118645466 cites W2080377533 @default.
• W3118645466 cites W2080940701 @default.
• W3118645466 cites W2103116273 @default.
• W3118645466 cites W2103550289 @default.
• W3118645466 cites W2109976761 @default.
• W3118645466 cites W2110516792 @default.
• W3118645466 cites W2114306298 @default.
• W3118645466 cites W2121392364 @default.
• W3118645466 cites W2122296425 @default.
• W3118645466 cites W2127023478 @default.
• W3118645466 cites W2136666944 @default.
• W3118645466 cites W2142304663 @default.
• W3118645466 cites W2142909591 @default.
• W3118645466 cites W2145195807 @default.
• W3118645466 cites W2149360415 @default.
• W3118645466 cites W2154398839 @default.
• W3118645466 cites W2165563020 @default.
• W3118645466 cites W2210109300 @default.
• W3118645466 cites W2239089357 @default.
• W3118645466 cites W2298338128 @default.
• W3118645466 cites W2312982528 @default.
• W3118645466 cites W2320535868 @default.
• W3118645466 cites W2322640064 @default.
• W3118645466 cites W2327587665 @default.
• W3118645466 cites W2331511638 @default.
• W3118645466 cites W2336031627 @default.
• W3118645466 cites W2336103857 @default.
• W3118645466 cites W2403001963 @default.
• W3118645466 cites W2467022164 @default.
• W3118645466 cites W2474213459 @default.
• W3118645466 cites W2474664935 @default.
• W3118645466 cites W2475862289 @default.
• W3118645466 cites W2493289085 @default.
• W3118645466 cites W2532941789 @default.
• W3118645466 cites W2551378118 @default.
• W3118645466 cites W2605499277 @default.
• W3118645466 cites W2616762518 @default.
• W3118645466 cites W2769583258 @default.
• W3118645466 cites W2771645665 @default.
• W3118645466 cites W2771882799 @default.
• W3118645466 cites W2883778763 @default.
• W3118645466 cites W2912683616 @default.
• W3118645466 cites W2914030870 @default.
• W3118645466 cites W2944133897 @default.
• W3118645466 cites W2948648397 @default.
• W3118645466 cites W2994655586 @default.

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