Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118672316> ?p ?o ?g. }
- W3118672316 endingPage "2342" @default.
- W3118672316 startingPage "2330" @default.
- W3118672316 abstract "Lung nociceptor neurons amplify immune cell activity and mucus metaplasia in response to an inhaled allergen challenge in sensitized mice.We sought to identify the cellular mechanisms by which these sensory neurons are activated subsequent to allergen exposure.We used calcium microscopy and electrophysiologic recording to assess whether vagal neurons directly respond to the model allergen ovalbumin (OVA). Next, we generated the first nociceptor-specific FcεR1γ knockdown (TRPV1Cre::FcεR1γfl/fl) mice to assess whether this targeted invalidation would affect the severity of allergic inflammation in response to allergen challenges.Lung-innervating jugular nodose complex ganglion neurons express the high-affinity IgE receptor FcεR1, the levels of which increase in OVA-sensitized mice. FcεR1γ-expressing vagal nociceptor neurons respond directly to OVA complexed with IgE with depolarization, action potential firing, calcium influx, and neuropeptide release. Activation of vagal neurons by IgE-allergen immune complexes, through the release of substance P from their peripheral terminals, directly amplifies TH2 cell influx and polarization in the airways. Allergic airway inflammation is decreased in TRPV1Cre::FcεR1γfl/fl mice and in FcεR1α-/- mice into which bone marrow has been transplanted. Finally, increased in vivo circulating levels of IgE following allergen sensitization enhances the responsiveness of FcεR1 to immune complexes in both mouse jugular nodose complex ganglion neurons and human induced pluripotent stem cell-derived nociceptors.Allergen sensitization triggers a feedforward inflammatory loop between IgE-producing plasma cells, FcεR1-expressing vagal sensory neurons, and TH2 cells, which helps to both initiate and amplify allergic airway inflammation. These data highlight a novel target for reducing allergy, namely, FcεR1γ expressed by nociceptors." @default.
- W3118672316 created "2021-01-18" @default.
- W3118672316 creator A5004599360 @default.
- W3118672316 creator A5005574463 @default.
- W3118672316 creator A5008262521 @default.
- W3118672316 creator A5011190239 @default.
- W3118672316 creator A5013387292 @default.
- W3118672316 creator A5017534594 @default.
- W3118672316 creator A5025073733 @default.
- W3118672316 creator A5026817060 @default.
- W3118672316 creator A5027916487 @default.
- W3118672316 creator A5039697077 @default.
- W3118672316 creator A5044410593 @default.
- W3118672316 creator A5044806364 @default.
- W3118672316 creator A5045911332 @default.
- W3118672316 creator A5050132863 @default.
- W3118672316 creator A5052174808 @default.
- W3118672316 creator A5053861341 @default.
- W3118672316 creator A5055643471 @default.
- W3118672316 creator A5059306059 @default.
- W3118672316 creator A5062576613 @default.
- W3118672316 creator A5065408959 @default.
- W3118672316 creator A5073083125 @default.
- W3118672316 creator A5078748688 @default.
- W3118672316 creator A5085811360 @default.
- W3118672316 date "2021-06-01" @default.
- W3118672316 modified "2023-10-02" @default.
- W3118672316 title "FcεR1-expressing nociceptors trigger allergic airway inflammation" @default.
- W3118672316 cites W1501994333 @default.
- W3118672316 cites W1513929611 @default.
- W3118672316 cites W1618626435 @default.
- W3118672316 cites W1623465125 @default.
- W3118672316 cites W1885892724 @default.
- W3118672316 cites W1955896568 @default.
- W3118672316 cites W1963857381 @default.
- W3118672316 cites W1972108403 @default.
- W3118672316 cites W1979773004 @default.
- W3118672316 cites W1982386486 @default.
- W3118672316 cites W1991488724 @default.
- W3118672316 cites W1995615606 @default.
- W3118672316 cites W1997242740 @default.
- W3118672316 cites W1999195261 @default.
- W3118672316 cites W2008351172 @default.
- W3118672316 cites W2016157874 @default.
- W3118672316 cites W2019447967 @default.
- W3118672316 cites W2022168094 @default.
- W3118672316 cites W2032006246 @default.
- W3118672316 cites W2033072655 @default.
- W3118672316 cites W2036271320 @default.
- W3118672316 cites W2039172739 @default.
- W3118672316 cites W2042457109 @default.
- W3118672316 cites W2044309378 @default.
- W3118672316 cites W2071602597 @default.
- W3118672316 cites W2073183851 @default.
- W3118672316 cites W2074277275 @default.
- W3118672316 cites W2078581339 @default.
- W3118672316 cites W2088102919 @default.
- W3118672316 cites W2089819518 @default.
- W3118672316 cites W2089926531 @default.
- W3118672316 cites W2090597220 @default.
- W3118672316 cites W2105197440 @default.
- W3118672316 cites W2109644936 @default.
- W3118672316 cites W2119256134 @default.
- W3118672316 cites W2124678205 @default.
- W3118672316 cites W2135896102 @default.
- W3118672316 cites W2140422012 @default.
- W3118672316 cites W2143907120 @default.
- W3118672316 cites W2148570600 @default.
- W3118672316 cites W2151301539 @default.
- W3118672316 cites W2154196772 @default.
- W3118672316 cites W2154644397 @default.
- W3118672316 cites W2157118802 @default.
- W3118672316 cites W2158259619 @default.
- W3118672316 cites W2160610710 @default.
- W3118672316 cites W2163379341 @default.
- W3118672316 cites W2166211238 @default.
- W3118672316 cites W2166702964 @default.
- W3118672316 cites W2180347427 @default.
- W3118672316 cites W2332618518 @default.
- W3118672316 cites W2418994609 @default.
- W3118672316 cites W2554691961 @default.
- W3118672316 cites W2583185711 @default.
- W3118672316 cites W2619512349 @default.
- W3118672316 cites W2627046609 @default.
- W3118672316 cites W2750992365 @default.
- W3118672316 cites W2751852104 @default.
- W3118672316 cites W2752706812 @default.
- W3118672316 cites W2755681539 @default.
- W3118672316 cites W2762851710 @default.
- W3118672316 cites W2766963797 @default.
- W3118672316 cites W2791770850 @default.
- W3118672316 cites W2912680846 @default.
- W3118672316 cites W2915048342 @default.
- W3118672316 cites W2922942986 @default.
- W3118672316 cites W2945959380 @default.
- W3118672316 cites W2946250451 @default.
- W3118672316 cites W2952423469 @default.
- W3118672316 cites W2958130081 @default.