Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118687954> ?p ?o ?g. }
- W3118687954 abstract "Abstract Prenatal alcohol exposure (PAE) causes permanent cognitive disability. The enteric microbiome generates microbial-dependent products (MDPs) that may contribute to disorders including autism, depression, and anxiety; it is unknown whether similar alterations occur in PAE. Using a mouse PAE model, we performed untargeted metabolome analyses upon the maternal–fetal dyad at gestational day 17.5. Hierarchical clustering by principal component analysis and Pearson’s correlation of maternal plasma (813 metabolites) both identified MDPs as significant predictors for PAE. The majority were phenolic acids enriched in PAE. Correlational network analyses revealed that alcohol altered plasma MDP-metabolite relationships, and alcohol-exposed maternal plasma was characterized by a subnetwork dominated by phenolic acids. Twenty-nine MDPs were detected in fetal liver and sixteen in fetal brain, where their impact is unknown. Several of these, including 4-ethylphenylsulfate, oxindole, indolepropionate, p-cresol sulfate, catechol sulfate, and salicylate, are implicated in other neurological disorders. We conclude that MDPs constitute a characteristic biosignature that distinguishes PAE. These MDPs are abundant in human plasma, where they influence physiology and disease. Their altered abundance here may reflect alcohol’s known effects on microbiota composition and gut permeability. We propose that the maternal microbiome and its MDPs are a previously unrecognized influence upon the pathologies that typify PAE." @default.
- W3118687954 created "2021-01-18" @default.
- W3118687954 creator A5012798503 @default.
- W3118687954 creator A5027711549 @default.
- W3118687954 creator A5042057797 @default.
- W3118687954 creator A5042319569 @default.
- W3118687954 creator A5047172508 @default.
- W3118687954 creator A5056239549 @default.
- W3118687954 creator A5071385773 @default.
- W3118687954 creator A5077067230 @default.
- W3118687954 date "2021-01-08" @default.
- W3118687954 modified "2023-10-17" @default.
- W3118687954 title "An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder" @default.
- W3118687954 cites W1716352502 @default.
- W3118687954 cites W1831301545 @default.
- W3118687954 cites W1885149309 @default.
- W3118687954 cites W1914622032 @default.
- W3118687954 cites W1972473451 @default.
- W3118687954 cites W1977429705 @default.
- W3118687954 cites W1993830991 @default.
- W3118687954 cites W2008871272 @default.
- W3118687954 cites W2011336591 @default.
- W3118687954 cites W2013165349 @default.
- W3118687954 cites W2013269826 @default.
- W3118687954 cites W2034801500 @default.
- W3118687954 cites W2057981650 @default.
- W3118687954 cites W2073714219 @default.
- W3118687954 cites W2086727869 @default.
- W3118687954 cites W2088781465 @default.
- W3118687954 cites W2090147676 @default.
- W3118687954 cites W2097136349 @default.
- W3118687954 cites W2101218751 @default.
- W3118687954 cites W2105096193 @default.
- W3118687954 cites W2106974808 @default.
- W3118687954 cites W2109329073 @default.
- W3118687954 cites W2110065044 @default.
- W3118687954 cites W2117029190 @default.
- W3118687954 cites W2130739949 @default.
- W3118687954 cites W2134897177 @default.
- W3118687954 cites W2143575031 @default.
- W3118687954 cites W2153947402 @default.
- W3118687954 cites W2155897723 @default.
- W3118687954 cites W2159675211 @default.
- W3118687954 cites W2191882717 @default.
- W3118687954 cites W2233635691 @default.
- W3118687954 cites W2292048640 @default.
- W3118687954 cites W2345604850 @default.
- W3118687954 cites W2492998196 @default.
- W3118687954 cites W2527872371 @default.
- W3118687954 cites W2558041282 @default.
- W3118687954 cites W2568352511 @default.
- W3118687954 cites W2577402974 @default.
- W3118687954 cites W2587766414 @default.
- W3118687954 cites W2592148887 @default.
- W3118687954 cites W2593775879 @default.
- W3118687954 cites W2600022567 @default.
- W3118687954 cites W2627092521 @default.
- W3118687954 cites W2737435763 @default.
- W3118687954 cites W2787902098 @default.
- W3118687954 cites W2792288381 @default.
- W3118687954 cites W2793407886 @default.
- W3118687954 cites W2799820352 @default.
- W3118687954 cites W2800336108 @default.
- W3118687954 cites W2800763374 @default.
- W3118687954 cites W2803938554 @default.
- W3118687954 cites W2804460705 @default.
- W3118687954 cites W2809475922 @default.
- W3118687954 cites W2809954937 @default.
- W3118687954 cites W2857010441 @default.
- W3118687954 cites W2900697674 @default.
- W3118687954 cites W2911143260 @default.
- W3118687954 cites W2912173893 @default.
- W3118687954 cites W2913620138 @default.
- W3118687954 cites W2921403009 @default.
- W3118687954 cites W2940592696 @default.
- W3118687954 cites W2948003108 @default.
- W3118687954 cites W2963083369 @default.
- W3118687954 cites W2967133951 @default.
- W3118687954 cites W2969023820 @default.
- W3118687954 cites W2978837562 @default.
- W3118687954 cites W2988550413 @default.
- W3118687954 cites W4254687493 @default.
- W3118687954 cites W969697792 @default.
- W3118687954 doi "https://doi.org/10.1038/s41598-020-80093-8" @default.
- W3118687954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7794323" @default.
- W3118687954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33420159" @default.
- W3118687954 hasPublicationYear "2021" @default.
- W3118687954 type Work @default.
- W3118687954 sameAs 3118687954 @default.
- W3118687954 citedByCount "20" @default.
- W3118687954 countsByYear W31186879542021 @default.
- W3118687954 countsByYear W31186879542022 @default.
- W3118687954 countsByYear W31186879542023 @default.
- W3118687954 crossrefType "journal-article" @default.
- W3118687954 hasAuthorship W3118687954A5012798503 @default.
- W3118687954 hasAuthorship W3118687954A5027711549 @default.
- W3118687954 hasAuthorship W3118687954A5042057797 @default.
- W3118687954 hasAuthorship W3118687954A5042319569 @default.
- W3118687954 hasAuthorship W3118687954A5047172508 @default.
- W3118687954 hasAuthorship W3118687954A5056239549 @default.