Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118696035> ?p ?o ?g. }
- W3118696035 endingPage "111872" @default.
- W3118696035 startingPage "111872" @default.
- W3118696035 abstract "In this study, electrospun scaffolds were fabricated by blending poly(l-lactide-co-ε-caprolactone) (PLCL) and silk fibroin (SF) with different ratios, and further the feasibility of electrospun PLCL/SF scaffolds were evaluated for application of tissue engineered heart valve (TEHV). Scanning electron microscopy (SEM) results showed that the surface of PLCL/SF electrospun scaffolds was smooth and uniform while the mechanical properties were appropriate as valve prosthesis. In vitro cytocompatibility evaluation results demonstrated that all of the PLCL/SF electrospun scaffolds were cytocompatible and valvular interstitial cells (VICs) cultured on PLCL/SF scaffolds of 80/20 & 70/30 ratios exhibited the best cytocompatibility. The in vitro osteogenic differentiation of VICs including alkaline phosphatase (ALP) activity and quantitative polymerase chain reaction (qPCR) assays indicated that PLCL/SF scaffolds of 80/20 & 90/10 ratios behaved better anti-calcification ability. In the in vivo calcification evaluation model of rat subdermal implantation, PLCL/SF scaffolds of 80/20 & 90/10 ratios presented better anti-calcification ability, which was consistent with the in vitro results. Moreover, PLCL/SF scaffolds of 80/20 & 70/30 ratios showed significantly enhanced cell infiltration and M2 macrophage with higher CD206+/CD68+ ratio. Collectively, our data demonstrated that electrospun scaffolds with the PLCL/SF ratio of 80/20 hold great potential as TEHV materials." @default.
- W3118696035 created "2021-01-18" @default.
- W3118696035 creator A5022967729 @default.
- W3118696035 creator A5024268530 @default.
- W3118696035 creator A5056345112 @default.
- W3118696035 creator A5059034854 @default.
- W3118696035 creator A5069878827 @default.
- W3118696035 creator A5074421479 @default.
- W3118696035 creator A5076034363 @default.
- W3118696035 creator A5088832009 @default.
- W3118696035 creator A5090424198 @default.
- W3118696035 date "2021-02-01" @default.
- W3118696035 modified "2023-10-18" @default.
- W3118696035 title "Biofabrication of poly(l-lactide-co-ε-caprolactone)/silk fibroin scaffold for the application as superb anti-calcification tissue engineered prosthetic valve" @default.
- W3118696035 cites W1094536179 @default.
- W3118696035 cites W1143976663 @default.
- W3118696035 cites W1528788646 @default.
- W3118696035 cites W1694481961 @default.
- W3118696035 cites W1967948255 @default.
- W3118696035 cites W1971361807 @default.
- W3118696035 cites W1976632391 @default.
- W3118696035 cites W1982380369 @default.
- W3118696035 cites W1994602476 @default.
- W3118696035 cites W1994910019 @default.
- W3118696035 cites W1998980656 @default.
- W3118696035 cites W2005079126 @default.
- W3118696035 cites W2007142909 @default.
- W3118696035 cites W2016349955 @default.
- W3118696035 cites W2018459477 @default.
- W3118696035 cites W2020050865 @default.
- W3118696035 cites W2022450317 @default.
- W3118696035 cites W2023394919 @default.
- W3118696035 cites W2026799007 @default.
- W3118696035 cites W2038112148 @default.
- W3118696035 cites W2039397292 @default.
- W3118696035 cites W2045924855 @default.
- W3118696035 cites W2050851013 @default.
- W3118696035 cites W2060077653 @default.
- W3118696035 cites W2061108278 @default.
- W3118696035 cites W2064538665 @default.
- W3118696035 cites W2072603386 @default.
- W3118696035 cites W2083156242 @default.
- W3118696035 cites W2083483036 @default.
- W3118696035 cites W2090004724 @default.
- W3118696035 cites W2117019694 @default.
- W3118696035 cites W2120451056 @default.
- W3118696035 cites W2122367477 @default.
- W3118696035 cites W2134560333 @default.
- W3118696035 cites W2148430806 @default.
- W3118696035 cites W2149435973 @default.
- W3118696035 cites W2156682347 @default.
- W3118696035 cites W2159076515 @default.
- W3118696035 cites W2159859242 @default.
- W3118696035 cites W2209695549 @default.
- W3118696035 cites W2319662446 @default.
- W3118696035 cites W2328393980 @default.
- W3118696035 cites W2426849648 @default.
- W3118696035 cites W2578656162 @default.
- W3118696035 cites W2580792129 @default.
- W3118696035 cites W2586644389 @default.
- W3118696035 cites W2621833807 @default.
- W3118696035 cites W2803009092 @default.
- W3118696035 cites W2897033234 @default.
- W3118696035 cites W2901371831 @default.
- W3118696035 cites W2913257775 @default.
- W3118696035 cites W2916079070 @default.
- W3118696035 cites W2924425191 @default.
- W3118696035 cites W2972228367 @default.
- W3118696035 cites W2974104685 @default.
- W3118696035 cites W3015234146 @default.
- W3118696035 cites W3042934867 @default.
- W3118696035 cites W4234854956 @default.
- W3118696035 cites W4242123567 @default.
- W3118696035 doi "https://doi.org/10.1016/j.msec.2021.111872" @default.
- W3118696035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33579497" @default.
- W3118696035 hasPublicationYear "2021" @default.
- W3118696035 type Work @default.
- W3118696035 sameAs 3118696035 @default.
- W3118696035 citedByCount "5" @default.
- W3118696035 countsByYear W31186960352022 @default.
- W3118696035 countsByYear W31186960352023 @default.
- W3118696035 crossrefType "journal-article" @default.
- W3118696035 hasAuthorship W3118696035A5022967729 @default.
- W3118696035 hasAuthorship W3118696035A5024268530 @default.
- W3118696035 hasAuthorship W3118696035A5056345112 @default.
- W3118696035 hasAuthorship W3118696035A5059034854 @default.
- W3118696035 hasAuthorship W3118696035A5069878827 @default.
- W3118696035 hasAuthorship W3118696035A5074421479 @default.
- W3118696035 hasAuthorship W3118696035A5076034363 @default.
- W3118696035 hasAuthorship W3118696035A5088832009 @default.
- W3118696035 hasAuthorship W3118696035A5090424198 @default.
- W3118696035 hasConcept C122302759 @default.
- W3118696035 hasConcept C136229726 @default.
- W3118696035 hasConcept C142724271 @default.
- W3118696035 hasConcept C144796933 @default.
- W3118696035 hasConcept C15920480 @default.
- W3118696035 hasConcept C159985019 @default.
- W3118696035 hasConcept C160160445 @default.