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• W3118701059 endingPage "e0245287" @default.
• W3118701059 startingPage "e0245287" @default.
• W3118701059 abstract "Patients with locally/regionally advanced melanoma were treated with neoadjuvant combination immunotherapy with high-dose interferon α-2b (HDI) and ipilimumab in a phase I clinical trial. Tumor specimens were obtained prior to the initiation of neoadjuvant therapy, at the time of surgery and progression if available. In this study, gene expression profiles of tumor specimens (N = 27) were investigated using the NanoString nCounter® platform to evaluate associations with clinical outcomes (pathologic response, radiologic response, relapse-free survival (RFS), and overall survival (OS)) and define biomarkers associated with tumor response. The Tumor Inflammation Signature (TIS), an 18-gene signature that enriches for response to Programmed cell death protein 1 (PD-1) checkpoint blockade, was also evaluated for association with clinical response and survival. It was observed that neoadjuvant ipilimumab-HDI therapy demonstrated an upregulation of immune-related genes, chemokines, and transcription regulator genes involved in immune cell activation, function, or cell proliferation. Importantly, increased expression of baseline pro-inflammatory genes CCL19 , CD3D , CD8A , CD22 , LY9 , IL12RB1 , C1S , C7 , AMICA1 , TIAM1 , TIGIT , THY1 was associated with longer OS ( p < 0.05). In addition, multiple genes that encode a component or a regulator of the extracellular matrix such as MMP2 and COL1A2 were identified post-treatment as being associated with longer RFS and OS. In all baseline tissues, high TIS scores were associated with longer OS ( p = 0.0166). Also, downregulated expression of cell proliferation-related genes such as CUL1 , CCND1 and AAMP at baseline was associated with pathological and radiological response (unadjusted p < 0.01). In conclusion, we identified numerous genes that play roles in multiple biological pathways involved in immune activation, immune suppression and cell proliferation correlating with pathological/radiological responses following neoadjuvant immunotherapy highlighting the complexity of immune responses modulated by immunotherapy. Our observations suggest that TIS may be a useful biomarker for predicting survival outcomes with combination immunotherapy." @default.
• W3118701059 created "2021-01-18" @default.
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• W3118701059 date "2021-01-11" @default.
• W3118701059 modified "2023-10-10" @default.
• W3118701059 title "CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma" @default.
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• W3118701059 doi "https://doi.org/10.1371/journal.pone.0245287" @default.
• W3118701059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7799833" @default.
• W3118701059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33428680" @default.
• W3118701059 hasPublicationYear "2021" @default.
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