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- W3118705118 abstract "African trypanosomes are early divergent protozoan parasites responsible for high mortality and morbidity as well as a great economic burden among the world's poorest populations. Trypanosomes undergo antigenic variation in their mammalian hosts, a highly sophisticated immune evasion mechanism. Their nuclear organization and mechanisms for gene expression control present several conventional features but also a number of striking differences to the mammalian counterparts. Some of these unorthodox characteristics, such as lack of controlled transcription initiation or enhancer sequences, render their monogenic antigen transcription, which is critical for successful antigenic variation, even more enigmatic. Recent technological developments have advanced our understanding of nuclear organization and gene expression control in trypanosomes, opening novel research avenues. This review is focused on Trypanosoma brucei nuclear organization and how it impacts gene expression, with an emphasis on antigen expression. It highlights several dedicated sub-nuclear bodies that compartmentalize specific functions, whilst outlining similarities and differences to more complex eukaryotes. Notably, understanding the mechanisms underpinning antigen as well as general gene expression control is of great importance, as it might help designing effective control strategies against these organisms." @default.
- W3118705118 created "2021-01-18" @default.
- W3118705118 creator A5021396236 @default.
- W3118705118 date "2021-01-07" @default.
- W3118705118 modified "2023-09-25" @default.
- W3118705118 title "A nuclear enterprise: zooming in on nuclear organization and gene expression control in the African trypanosome" @default.
- W3118705118 cites W1503113774 @default.
- W3118705118 cites W1506886301 @default.
- W3118705118 cites W1567582741 @default.
- W3118705118 cites W1576894338 @default.
- W3118705118 cites W1753097875 @default.
- W3118705118 cites W1832149706 @default.
- W3118705118 cites W1907070203 @default.
- W3118705118 cites W1934638475 @default.
- W3118705118 cites W1961772435 @default.
- W3118705118 cites W1963773259 @default.
- W3118705118 cites W1964184081 @default.
- W3118705118 cites W1969670694 @default.
- W3118705118 cites W1973062929 @default.
- W3118705118 cites W1980608545 @default.
- W3118705118 cites W1981494299 @default.
- W3118705118 cites W1983455858 @default.
- W3118705118 cites W1983970357 @default.
- W3118705118 cites W1984022579 @default.
- W3118705118 cites W1985557583 @default.
- W3118705118 cites W1988904557 @default.
- W3118705118 cites W1989150820 @default.
- W3118705118 cites W1990031610 @default.
- W3118705118 cites W1996255730 @default.
- W3118705118 cites W1996415959 @default.
- W3118705118 cites W1999440327 @default.
- W3118705118 cites W1999617465 @default.
- W3118705118 cites W2011326960 @default.
- W3118705118 cites W2013078522 @default.
- W3118705118 cites W2014619760 @default.
- W3118705118 cites W2016469359 @default.
- W3118705118 cites W2020067096 @default.
- W3118705118 cites W2026382372 @default.
- W3118705118 cites W2027479769 @default.
- W3118705118 cites W2031395158 @default.
- W3118705118 cites W2031922297 @default.
- W3118705118 cites W2032618417 @default.
- W3118705118 cites W2034383160 @default.
- W3118705118 cites W2041036553 @default.
- W3118705118 cites W2041634189 @default.
- W3118705118 cites W2044138508 @default.
- W3118705118 cites W2045828490 @default.
- W3118705118 cites W2048769514 @default.
- W3118705118 cites W2061993563 @default.
- W3118705118 cites W2065943045 @default.
- W3118705118 cites W2067686625 @default.
- W3118705118 cites W2071780594 @default.
- W3118705118 cites W2078336790 @default.
- W3118705118 cites W2080413629 @default.
- W3118705118 cites W2081553037 @default.
- W3118705118 cites W2084929037 @default.
- W3118705118 cites W2091721155 @default.
- W3118705118 cites W2091794350 @default.
- W3118705118 cites W2092215837 @default.
- W3118705118 cites W2095453275 @default.
- W3118705118 cites W2096262820 @default.
- W3118705118 cites W2096985831 @default.
- W3118705118 cites W2097227527 @default.
- W3118705118 cites W2098549100 @default.
- W3118705118 cites W2098648205 @default.
- W3118705118 cites W2099889296 @default.
- W3118705118 cites W2100845718 @default.
- W3118705118 cites W2101956881 @default.
- W3118705118 cites W2103550307 @default.
- W3118705118 cites W2105688902 @default.
- W3118705118 cites W2106241373 @default.
- W3118705118 cites W2108709147 @default.
- W3118705118 cites W2110419228 @default.
- W3118705118 cites W2111565312 @default.
- W3118705118 cites W2111806909 @default.
- W3118705118 cites W2111957248 @default.
- W3118705118 cites W2112973138 @default.
- W3118705118 cites W2115094314 @default.
- W3118705118 cites W2117791601 @default.
- W3118705118 cites W2119326760 @default.
- W3118705118 cites W2119852049 @default.
- W3118705118 cites W2120937476 @default.
- W3118705118 cites W2123943121 @default.
- W3118705118 cites W2125281851 @default.
- W3118705118 cites W2127394968 @default.
- W3118705118 cites W2130652958 @default.
- W3118705118 cites W2131472651 @default.
- W3118705118 cites W2132025509 @default.
- W3118705118 cites W2134441385 @default.
- W3118705118 cites W2137559575 @default.
- W3118705118 cites W2138659224 @default.
- W3118705118 cites W2141206612 @default.
- W3118705118 cites W2141805043 @default.
- W3118705118 cites W2144704949 @default.
- W3118705118 cites W2144924990 @default.
- W3118705118 cites W2146783179 @default.
- W3118705118 cites W2147963299 @default.
- W3118705118 cites W2150215006 @default.