FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118711266> ?p ?o ?g. }

• W3118711266 endingPage "166" @default.
• W3118711266 startingPage "156" @default.
• W3118711266 abstract "Abstract Leukemic cells display some alterations in metabolic pathways, which play a role in leukemogenesis and in patients’ prognosis. To evaluate the characteristics and the impact of this metabolic reprogramming, we explore the bone marrow samples from 54 de novo acute myeloid leukemia (AML) patients, using an untargeted metabolomics approach based on proton high-resolution magic angle spinning-nuclear magnetic resonance. The spectra obtained were subjected to multivariate statistical analysis to find specific metabolome alterations and biomarkers correlated to clinical features. We found that patients display a large diversity of metabolic profiles, according to the different AML cytologic subtypes and molecular statuses. The link between metabolism and molecular status was particularly strong for the oncometabolite 2-hydroxyglutarate (2-HG), whose intracellular production is directly linked to the presence of isocitrate dehydrogenase mutations. Moreover, patients’ prognosis was strongly impacted by several metabolites, such as 2-HG that appeared as a good prognostic biomarker in our cohort. Conversely, deregulations in phospholipid metabolism had a negative impact on prognosis through 2 main metabolites (phosphocholine and phosphoethanolamine), which could be potential aggressiveness biomarkers. Finally, we highlighted an overexpression of glutathione and alanine in chemoresistant patients. Overall, our results demonstrate that different metabolic pathways could be activated in leukemic cells according to their phenotype and maturation levels. This confirms that metabolic reprogramming strongly influences prognosis of patients and underscores a particular role of certain metabolites and associated pathways in AML prognosis, suggesting common mechanisms developed by leukemic cells to maintain their aggressiveness even after well-conducted induction chemotherapy." @default.
• W3118711266 created "2021-01-18" @default.
• W3118711266 creator A5005591161 @default.
• W3118711266 creator A5019754040 @default.
• W3118711266 creator A5029449586 @default.
• W3118711266 creator A5061502217 @default.
• W3118711266 creator A5067360242 @default.
• W3118711266 date "2021-01-06" @default.
• W3118711266 modified "2023-10-16" @default.
• W3118711266 title "The metabolic reprogramming in acute myeloid leukemia patients depends on their genotype and is a prognostic marker" @default.
• W3118711266 cites W1527939041 @default.
• W3118711266 cites W1834978976 @default.
• W3118711266 cites W1972614642 @default.
• W3118711266 cites W1975267683 @default.
• W3118711266 cites W1975705021 @default.
• W3118711266 cites W1980904297 @default.
• W3118711266 cites W1985197354 @default.
• W3118711266 cites W1994322821 @default.
• W3118711266 cites W2023014046 @default.
• W3118711266 cites W2035935275 @default.
• W3118711266 cites W2035972383 @default.
• W3118711266 cites W2059758368 @default.
• W3118711266 cites W2063441242 @default.
• W3118711266 cites W2064599696 @default.
• W3118711266 cites W2066236650 @default.
• W3118711266 cites W2080452140 @default.
• W3118711266 cites W2096258216 @default.
• W3118711266 cites W2111866362 @default.
• W3118711266 cites W2134450454 @default.
• W3118711266 cites W2325815501 @default.
• W3118711266 cites W2485931681 @default.
• W3118711266 cites W2516006356 @default.
• W3118711266 cites W2582892663 @default.
• W3118711266 cites W2597755234 @default.
• W3118711266 cites W2605757478 @default.
• W3118711266 cites W2611946404 @default.
• W3118711266 cites W2766586060 @default.
• W3118711266 cites W2770656572 @default.
• W3118711266 cites W2782192099 @default.
• W3118711266 cites W2793196942 @default.
• W3118711266 cites W2796145897 @default.
• W3118711266 cites W2797582589 @default.
• W3118711266 cites W2803962537 @default.
• W3118711266 cites W2809388839 @default.
• W3118711266 cites W2889481010 @default.
• W3118711266 cites W2901666024 @default.
• W3118711266 cites W2909472453 @default.
• W3118711266 cites W2914831074 @default.
• W3118711266 cites W2918585906 @default.
• W3118711266 cites W2953705511 @default.
• W3118711266 cites W2966025128 @default.
• W3118711266 cites W2979422509 @default.
• W3118711266 cites W2981560623 @default.
• W3118711266 cites W2989700374 @default.
• W3118711266 cites W2999433265 @default.
• W3118711266 cites W4231346141 @default.
• W3118711266 cites W4241534679 @default.
• W3118711266 doi "https://doi.org/10.1182/bloodadvances.2020002981" @default.
• W3118711266 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7805315" @default.
• W3118711266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33570627" @default.
• W3118711266 hasPublicationYear "2021" @default.
• W3118711266 type Work @default.
• W3118711266 sameAs 3118711266 @default.
• W3118711266 citedByCount "23" @default.
• W3118711266 countsByYear W31187112662021 @default.
• W3118711266 countsByYear W31187112662022 @default.
• W3118711266 countsByYear W31187112662023 @default.
• W3118711266 crossrefType "journal-article" @default.
• W3118711266 hasAuthorship W3118711266A5005591161 @default.
• W3118711266 hasAuthorship W3118711266A5019754040 @default.
• W3118711266 hasAuthorship W3118711266A5029449586 @default.
• W3118711266 hasAuthorship W3118711266A5061502217 @default.
• W3118711266 hasAuthorship W3118711266A5067360242 @default.
• W3118711266 hasBestOaLocation W31187112661 @default.
• W3118711266 hasConcept C104317684 @default.
• W3118711266 hasConcept C126322002 @default.
• W3118711266 hasConcept C127716648 @default.
• W3118711266 hasConcept C134018914 @default.
• W3118711266 hasConcept C135870905 @default.
• W3118711266 hasConcept C1491633281 @default.
• W3118711266 hasConcept C181199279 @default.
• W3118711266 hasConcept C192989942 @default.
• W3118711266 hasConcept C203014093 @default.
• W3118711266 hasConcept C21565614 @default.
• W3118711266 hasConcept C2776330855 @default.
• W3118711266 hasConcept C2776923060 @default.
• W3118711266 hasConcept C2777150147 @default.
• W3118711266 hasConcept C2777477808 @default.
• W3118711266 hasConcept C2778461978 @default.
• W3118711266 hasConcept C2778729363 @default.
• W3118711266 hasConcept C2778918659 @default.
• W3118711266 hasConcept C2779282312 @default.
• W3118711266 hasConcept C41625074 @default.
• W3118711266 hasConcept C502942594 @default.
• W3118711266 hasConcept C54355233 @default.
• W3118711266 hasConcept C55493867 @default.
• W3118711266 hasConcept C60644358 @default.
• W3118711266 hasConcept C62231903 @default.

• next