FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118743600> ?p ?o ?g. }

• W3118743600 endingPage "399" @default.
• W3118743600 startingPage "384" @default.
• W3118743600 abstract "Most studies that have examined the transcriptional response to GH have been performed with a single tissue. Thus, the current study performed RNASeq across three insulin-sensitive tissues of GH-treated GH deficient (GHKO) mice.GHKO mice were injected with recombinant human GH (hGH) or vehicle daily for 5 days and adipose, liver, and muscle tissues were collected 4 h after the final injection. RNA was isolated from the tissues and sequenced. Genes that were differentially expressed between GH and vehicle treatments were further analyzed. Enrichment analysis and topology-aware pathway analysis were performed.GHKO mice treated with hGH had expected phenotypic alterations, with increased body, fat, fluid, liver, and muscle mass, and increased serum IGF-1 and insulin. 55 Genes were differentially expressed in all three tissues, including the canonical GH targets Igf1, Igfals, and Cish. Enrichment analysis confirmed the canonical GH response in select tissues, such as cell proliferation, metabolism, and fibrosis. The JAK/STAT pathway was the only pathway significantly altered in all three tissues.As expected, GH caused expression changes of many known target genes, although new candidate GH targets were identified. Liver and muscle appear to be more GH sensitive than adipose tissue due to the larger number of DEG and pathways significantly altered, but adipose still has a characteristic GH response. The diversity of changes uncovered in all three tissues after 5 days of GH treatment highlights the multiplicity of GH's effects in its target tissues." @default.
• W3118743600 created "2021-01-18" @default.
• W3118743600 creator A5012588350 @default.
• W3118743600 creator A5031412238 @default.
• W3118743600 creator A5042731959 @default.
• W3118743600 creator A5054006122 @default.
• W3118743600 creator A5062142179 @default.
• W3118743600 creator A5067315285 @default.
• W3118743600 creator A5069215770 @default.
• W3118743600 creator A5070652111 @default.
• W3118743600 date "2021-01-12" @default.
• W3118743600 modified "2023-10-14" @default.
• W3118743600 title "Transcriptome profiling of insulin sensitive tissues from GH deficient mice following GH treatment" @default.
• W3118743600 cites W1578717458 @default.
• W3118743600 cites W1764233934 @default.
• W3118743600 cites W1940253467 @default.
• W3118743600 cites W1966611402 @default.
• W3118743600 cites W1971544693 @default.
• W3118743600 cites W1973309749 @default.
• W3118743600 cites W1987364229 @default.
• W3118743600 cites W1989275114 @default.
• W3118743600 cites W1989277387 @default.
• W3118743600 cites W1999022163 @default.
• W3118743600 cites W2016669978 @default.
• W3118743600 cites W2028850435 @default.
• W3118743600 cites W2030601224 @default.
• W3118743600 cites W2030729252 @default.
• W3118743600 cites W2042564244 @default.
• W3118743600 cites W2054121324 @default.
• W3118743600 cites W2066916173 @default.
• W3118743600 cites W2071447707 @default.
• W3118743600 cites W2079264385 @default.
• W3118743600 cites W2095380669 @default.
• W3118743600 cites W2110687686 @default.
• W3118743600 cites W2119467744 @default.
• W3118743600 cites W2129582583 @default.
• W3118743600 cites W2135030836 @default.
• W3118743600 cites W2137918056 @default.
• W3118743600 cites W2148043260 @default.
• W3118743600 cites W2150439293 @default.
• W3118743600 cites W2154672297 @default.
• W3118743600 cites W2156136676 @default.
• W3118743600 cites W2159482845 @default.
• W3118743600 cites W2169587764 @default.
• W3118743600 cites W2174734928 @default.
• W3118743600 cites W2314743173 @default.
• W3118743600 cites W2324996294 @default.
• W3118743600 cites W2566771799 @default.
• W3118743600 cites W2611137559 @default.
• W3118743600 cites W2767914218 @default.
• W3118743600 cites W2776528345 @default.
• W3118743600 cites W2901332105 @default.
• W3118743600 cites W2944545583 @default.
• W3118743600 cites W2945066741 @default.
• W3118743600 cites W2950595506 @default.
• W3118743600 cites W2961423484 @default.
• W3118743600 cites W3006306388 @default.
• W3118743600 cites W3036759995 @default.
• W3118743600 cites W3044374557 @default.
• W3118743600 cites W3091894104 @default.
• W3118743600 cites W4231254854 @default.
• W3118743600 cites W4243979784 @default.
• W3118743600 cites W4255156463 @default.
• W3118743600 cites W4294216483 @default.
• W3118743600 doi "https://doi.org/10.1007/s11102-020-01118-z" @default.
• W3118743600 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8122029" @default.
• W3118743600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33433889" @default.
• W3118743600 hasPublicationYear "2021" @default.
• W3118743600 type Work @default.
• W3118743600 sameAs 3118743600 @default.
• W3118743600 citedByCount "3" @default.
• W3118743600 countsByYear W31187436002023 @default.
• W3118743600 crossrefType "journal-article" @default.
• W3118743600 hasAuthorship W3118743600A5012588350 @default.
• W3118743600 hasAuthorship W3118743600A5031412238 @default.
• W3118743600 hasAuthorship W3118743600A5042731959 @default.
• W3118743600 hasAuthorship W3118743600A5054006122 @default.
• W3118743600 hasAuthorship W3118743600A5062142179 @default.
• W3118743600 hasAuthorship W3118743600A5067315285 @default.
• W3118743600 hasAuthorship W3118743600A5069215770 @default.
• W3118743600 hasAuthorship W3118743600A5070652111 @default.
• W3118743600 hasBestOaLocation W31187436002 @default.
• W3118743600 hasConcept C104317684 @default.
• W3118743600 hasConcept C126322002 @default.
• W3118743600 hasConcept C134018914 @default.
• W3118743600 hasConcept C150194340 @default.
• W3118743600 hasConcept C162317418 @default.
• W3118743600 hasConcept C171089720 @default.
• W3118743600 hasConcept C2779306644 @default.
• W3118743600 hasConcept C2780559512 @default.
• W3118743600 hasConcept C54355233 @default.
• W3118743600 hasConcept C71924100 @default.
• W3118743600 hasConcept C86803240 @default.
• W3118743600 hasConceptScore W3118743600C104317684 @default.
• W3118743600 hasConceptScore W3118743600C126322002 @default.
• W3118743600 hasConceptScore W3118743600C134018914 @default.
• W3118743600 hasConceptScore W3118743600C150194340 @default.
• W3118743600 hasConceptScore W3118743600C162317418 @default.

• next