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- W3118751708 abstract "Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2 cells can arise in the embryonic thymus from shared T cell precursors, preceding the emergence of CD4+CD8+ (double-positive) T cells. Thymic ILC2 cells migrated to mucosal tissues, with colonization of the intestinal lamina propria. Expression of the transcription factor RORα repressed T cell development while promoting ILC2 development in the thymus. From RNA-seq, assay for transposase-accessible chromatin sequencing (ATAC-seq) and chromatin immunoprecipitation followed by sequencing (ChIP-seq) data, we propose a revised transcriptional circuit to explain the co-development of T cells and ILC2 cells from common progenitors in the thymus. When Notch signaling is present, BCL11B dampens Nfil3 and Id2 expression, permitting E protein-directed T cell commitment. However, concomitant expression of RORα overrides the repression of Nfil3 and Id2 repression, allowing ID2 to repress E proteins and promote ILC2 differentiation. Thus, we demonstrate that RORα expression represents a critical checkpoint at the bifurcation of the T cell and ILC2 lineages in the embryonic thymus." @default.
- W3118751708 created "2021-01-18" @default.
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- W3118751708 date "2021-01-11" @default.
- W3118751708 modified "2023-09-26" @default.
- W3118751708 title "RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus" @default.
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- W3118751708 doi "https://doi.org/10.1038/s41590-020-00833-w" @default.
- W3118751708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7116838" @default.
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- W3118751708 hasPublicationYear "2021" @default.
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