FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118757310> ?p ?o ?g. }

• W3118757310 endingPage "e10671" @default.
• W3118757310 startingPage "e10671" @default.
• W3118757310 abstract "Fibroblast growth factor 2 (FGF2) is a highly pleiotropic cytokine with antifibrotic activity in wound healing. During the process of wound healing and fibrosis, fibroblasts are the key players. Although accumulating evidence has suggested the antagonistic effects of FGF2 in the activation process of fibroblasts, the mechanisms by which FGF2 hinders the fibroblast activation remains incompletely understood. This study aimed to identify the key genes and their regulatory networks in skin fibroblasts treated with FGF2.RNA-seq was performed to identify the differentially expressed mRNA (DEGs) and lncRNA between FGF2-treated fibroblasts and control. DEGs were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Furthermore, the networks between mRNAs and lncRNAs were constructed by Pearson correlation analysis and the networkanalyst website. Finally, hub genes were validated by real time-PCR.Between FGF2-treated fibroblasts and control fibroblasts, a total of 1475 DEGs was obtained. These DEGs were mainly enriched in functions such as the ECM organization, cell adhesion, and cell migration. They were mainly involved in ECM-receptor interaction, PI3K-Akt signaling, and the Hippo pathway. The hub DEGs included COL3A1, COL4A1, LOX, PDGFA, TGFBI, and ITGA10. Subsequent real-time PCR, as well as bioinformatics analysis, consistently demonstrated that the expression of ITGA10 was significantly upregulated while the other five DEGs (COL3A1, COL4A1, LOX, PDGFA, TGFBI) were downregulated in FGF2-treated fibroblasts. Meanwhile, 213 differentially expressed lncRNAs were identified and three key lncRNAs (HOXA-AS2, H19, and SNHG8) were highlighted in FGF2-treated fibroblasts.The current study comprehensively analyzed the FGF2-responsive transcriptional profile and provided candidate mechanisms that may account for FGF2-mediated wound healing." @default.
• W3118757310 created "2021-01-18" @default.
• W3118757310 creator A5002325397 @default.
• W3118757310 creator A5013642068 @default.
• W3118757310 creator A5025721107 @default.
• W3118757310 creator A5037203449 @default.
• W3118757310 creator A5060401991 @default.
• W3118757310 creator A5061116748 @default.
• W3118757310 date "2021-01-15" @default.
• W3118757310 modified "2023-09-23" @default.
• W3118757310 title "RNA sequencing analysis of FGF2-responsive transcriptome in skin fibroblasts" @default.
• W3118757310 cites W1523901771 @default.
• W3118757310 cites W1591280387 @default.
• W3118757310 cites W1926017383 @default.
• W3118757310 cites W1967440568 @default.
• W3118757310 cites W1970940391 @default.
• W3118757310 cites W2003758382 @default.
• W3118757310 cites W2009929357 @default.
• W3118757310 cites W2072303535 @default.
• W3118757310 cites W2079587671 @default.
• W3118757310 cites W2090814621 @default.
• W3118757310 cites W2110892399 @default.
• W3118757310 cites W2124293953 @default.
• W3118757310 cites W2143391967 @default.
• W3118757310 cites W2203577167 @default.
• W3118757310 cites W2256566268 @default.
• W3118757310 cites W2302332254 @default.
• W3118757310 cites W2398601466 @default.
• W3118757310 cites W2402832492 @default.
• W3118757310 cites W2736102792 @default.
• W3118757310 cites W2750719762 @default.
• W3118757310 cites W2758173799 @default.
• W3118757310 cites W2793137301 @default.
• W3118757310 cites W2809820528 @default.
• W3118757310 cites W2892230172 @default.
• W3118757310 cites W2929580832 @default.
• W3118757310 cites W2933620885 @default.
• W3118757310 cites W2944617715 @default.
• W3118757310 cites W2944874362 @default.
• W3118757310 cites W2970147023 @default.
• W3118757310 cites W2995002380 @default.
• W3118757310 cites W2998617660 @default.
• W3118757310 cites W3000005426 @default.
• W3118757310 cites W3000959293 @default.
• W3118757310 cites W3004357407 @default.
• W3118757310 cites W3039257639 @default.
• W3118757310 cites W4252650885 @default.
• W3118757310 doi "https://doi.org/10.7717/peerj.10671" @default.
• W3118757310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7812929" @default.
• W3118757310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33520460" @default.
• W3118757310 hasPublicationYear "2021" @default.
• W3118757310 type Work @default.
• W3118757310 sameAs 3118757310 @default.
• W3118757310 citedByCount "4" @default.
• W3118757310 countsByYear W31187573102022 @default.
• W3118757310 countsByYear W31187573102023 @default.
• W3118757310 crossrefType "journal-article" @default.
• W3118757310 hasAuthorship W3118757310A5002325397 @default.
• W3118757310 hasAuthorship W3118757310A5013642068 @default.
• W3118757310 hasAuthorship W3118757310A5025721107 @default.
• W3118757310 hasAuthorship W3118757310A5037203449 @default.
• W3118757310 hasAuthorship W3118757310A5060401991 @default.
• W3118757310 hasAuthorship W3118757310A5061116748 @default.
• W3118757310 hasBestOaLocation W31187573101 @default.
• W3118757310 hasConcept C104317684 @default.
• W3118757310 hasConcept C118131993 @default.
• W3118757310 hasConcept C150194340 @default.
• W3118757310 hasConcept C152724338 @default.
• W3118757310 hasConcept C162317418 @default.
• W3118757310 hasConcept C170493617 @default.
• W3118757310 hasConcept C2778615650 @default.
• W3118757310 hasConcept C2780269544 @default.
• W3118757310 hasConcept C2780381497 @default.
• W3118757310 hasConcept C54355233 @default.
• W3118757310 hasConcept C74373430 @default.
• W3118757310 hasConcept C81885089 @default.
• W3118757310 hasConcept C86803240 @default.
• W3118757310 hasConcept C95444343 @default.
• W3118757310 hasConceptScore W3118757310C104317684 @default.
• W3118757310 hasConceptScore W3118757310C118131993 @default.
• W3118757310 hasConceptScore W3118757310C150194340 @default.
• W3118757310 hasConceptScore W3118757310C152724338 @default.
• W3118757310 hasConceptScore W3118757310C162317418 @default.
• W3118757310 hasConceptScore W3118757310C170493617 @default.
• W3118757310 hasConceptScore W3118757310C2778615650 @default.
• W3118757310 hasConceptScore W3118757310C2780269544 @default.
• W3118757310 hasConceptScore W3118757310C2780381497 @default.
• W3118757310 hasConceptScore W3118757310C54355233 @default.
• W3118757310 hasConceptScore W3118757310C74373430 @default.
• W3118757310 hasConceptScore W3118757310C81885089 @default.
• W3118757310 hasConceptScore W3118757310C86803240 @default.
• W3118757310 hasConceptScore W3118757310C95444343 @default.
• W3118757310 hasFunder F4320309612 @default.
• W3118757310 hasFunder F4320321001 @default.
• W3118757310 hasLocation W31187573101 @default.
• W3118757310 hasLocation W31187573102 @default.
• W3118757310 hasLocation W31187573103 @default.
• W3118757310 hasLocation W31187573104 @default.

• next