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- W3118776656 abstract "Amaç: Testis torsiyonu birkaç saat içinde tedavi edilmezse erkeklerde testis atrofisine ve kısırlığa neden olabilir. Antioksidan ajanlar testis torsiyonu ile baş etmede hedefler arasındadır. Mirisetin (myricetin, 3, 3, 4, 5, 5, 7-hekzahidroksiflavon, MYR), antioksidan, antikanser, anti-inflamatuar, antiviral ve antidiyabetik aktivitelere sahiptir. Gereç ve Yöntemler: 32 adet Wistar albino erkek sıçan rastgele 4 gruba (n=8) ayrıldı. Grup I sham grup olarak tanımlandı. Grup II, I/R grubunda testis torsiyonu yapıldı. Grup III (MYR 25) ve grup IV'te (MYR 50), detorsiyondan 30 dakika önce 25 ve 50 mg/kg dozlarda MYR intraperitoneal olarak uygulandı. Testis ve akciğer doku örnekleri biyokimyasal olarak incelendi. Bulgular: Testis ve akciğer dokularında MYR, I/R grubuna kıyasla hem yüksek hem de düşük dozlarda TOS, MPO ve MDA seviyelerini azaltmıştır. Ayrıca MYR uygulanan gruplarda I/R grubuna kıyasla SOD değerleri artmıştır. Sonuç: Biyokimyasal parametreler değerlendirildiğinde, MYR testis I/R hasarını takiben testis ve akciğer dokuları üzerinde olumlu etkiler gösterdi." @default.
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- W3118776656 date "2021-01-07" @default.
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- W3118776656 title "Mirisetinin Testiküler İskemi Reperfüzyon ile İndüklenen Testis ve Akciğer Hasarına Karşı Etkileri" @default.
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- W3118776656 doi "https://doi.org/10.31832/smj.783480" @default.
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