Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118777720> ?p ?o ?g. }
- W3118777720 endingPage "81" @default.
- W3118777720 startingPage "81" @default.
- W3118777720 abstract "Type 2 diabetes mellitus (T2DM) is one of the largest public health problems worldwide. Insulin resistance-related metabolic dysfunction and chronic hyperglycemia result in devastating complications and poor prognosis. Even though there are many conventional drugs such as metformin (MET), Thiazolidinediones (TZDs), sulfonylureas (SUF), dipeptidyl peptidase 4 (DPP-4) inhibitors, glucagon like peptide 1 (GLP-1) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors, side effects still exist. As numerous plant extracts with antidiabetic effects have been widely reported, they have the potential to be a great therapeutic agent for type 2 diabetes with less side effects. In this study, sixty-five recent studies regarding plant extracts that alleviate type 2 diabetes were reviewed. Plant extracts regulated blood glucose through the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. The anti-inflammatory and antioxidant properties of plant extracts suppressed c-Jun amino terminal kinase (JNK) and nuclear factor kappa B (NF-κB) pathways, which induce insulin resistance. Lipogenesis and fatty acid oxidation, which are also associated with insulin resistance, are regulated by AMP-activated protein kinase (AMPK) activation. This review focuses on discovering plant extracts that alleviate type 2 diabetes and exploring its therapeutic mechanisms." @default.
- W3118777720 created "2021-01-18" @default.
- W3118777720 creator A5018977246 @default.
- W3118777720 creator A5027051542 @default.
- W3118777720 creator A5036846754 @default.
- W3118777720 creator A5058885060 @default.
- W3118777720 date "2021-01-09" @default.
- W3118777720 modified "2023-10-05" @default.
- W3118777720 title "Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug Discovery" @default.
- W3118777720 cites W1541855131 @default.
- W3118777720 cites W1556721384 @default.
- W3118777720 cites W1605496649 @default.
- W3118777720 cites W1869942395 @default.
- W3118777720 cites W1967667786 @default.
- W3118777720 cites W1971041352 @default.
- W3118777720 cites W1974780985 @default.
- W3118777720 cites W1979340145 @default.
- W3118777720 cites W1984255412 @default.
- W3118777720 cites W1985790075 @default.
- W3118777720 cites W1996220869 @default.
- W3118777720 cites W1998683206 @default.
- W3118777720 cites W2005631387 @default.
- W3118777720 cites W2011574523 @default.
- W3118777720 cites W2016032649 @default.
- W3118777720 cites W2034921827 @default.
- W3118777720 cites W2036622936 @default.
- W3118777720 cites W2056701097 @default.
- W3118777720 cites W2077215237 @default.
- W3118777720 cites W2085567056 @default.
- W3118777720 cites W2093343938 @default.
- W3118777720 cites W2099905857 @default.
- W3118777720 cites W2101705409 @default.
- W3118777720 cites W2105153491 @default.
- W3118777720 cites W2109027353 @default.
- W3118777720 cites W2109554224 @default.
- W3118777720 cites W2118787348 @default.
- W3118777720 cites W2120902612 @default.
- W3118777720 cites W2124877552 @default.
- W3118777720 cites W2152377123 @default.
- W3118777720 cites W2154133061 @default.
- W3118777720 cites W2162481722 @default.
- W3118777720 cites W2171553260 @default.
- W3118777720 cites W2207249397 @default.
- W3118777720 cites W2213069624 @default.
- W3118777720 cites W2237947683 @default.
- W3118777720 cites W2254168655 @default.
- W3118777720 cites W2255443535 @default.
- W3118777720 cites W2264105514 @default.
- W3118777720 cites W2266541538 @default.
- W3118777720 cites W2280954291 @default.
- W3118777720 cites W2295270525 @default.
- W3118777720 cites W2296510841 @default.
- W3118777720 cites W2328184451 @default.
- W3118777720 cites W2337194528 @default.
- W3118777720 cites W2346158578 @default.
- W3118777720 cites W2347144987 @default.
- W3118777720 cites W2395434738 @default.
- W3118777720 cites W2479971468 @default.
- W3118777720 cites W2495941601 @default.
- W3118777720 cites W2519322572 @default.
- W3118777720 cites W2531313400 @default.
- W3118777720 cites W2547609515 @default.
- W3118777720 cites W2554512031 @default.
- W3118777720 cites W2564093285 @default.
- W3118777720 cites W2570066512 @default.
- W3118777720 cites W2572191046 @default.
- W3118777720 cites W2579921278 @default.
- W3118777720 cites W2582388598 @default.
- W3118777720 cites W2588611799 @default.
- W3118777720 cites W2593325807 @default.
- W3118777720 cites W2599082417 @default.
- W3118777720 cites W2618007882 @default.
- W3118777720 cites W2625887862 @default.
- W3118777720 cites W2733167651 @default.
- W3118777720 cites W2734445818 @default.
- W3118777720 cites W2745299522 @default.
- W3118777720 cites W2752039963 @default.
- W3118777720 cites W2754756914 @default.
- W3118777720 cites W2765129278 @default.
- W3118777720 cites W2767382522 @default.
- W3118777720 cites W2767960997 @default.
- W3118777720 cites W2771654487 @default.
- W3118777720 cites W2781978613 @default.
- W3118777720 cites W2783380892 @default.
- W3118777720 cites W2788526343 @default.
- W3118777720 cites W2793194513 @default.
- W3118777720 cites W2799617991 @default.
- W3118777720 cites W2801940916 @default.
- W3118777720 cites W2802278998 @default.
- W3118777720 cites W2803885695 @default.
- W3118777720 cites W2807347600 @default.
- W3118777720 cites W2808824662 @default.
- W3118777720 cites W2810673588 @default.
- W3118777720 cites W2884334418 @default.
- W3118777720 cites W2884952190 @default.
- W3118777720 cites W2886504687 @default.
- W3118777720 cites W2890254416 @default.
- W3118777720 cites W2890262909 @default.