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- W3118778885 abstract "Theiler’s murine encephalomyelitis virus (TMEV) infection is a murine model for a variety of human diseases including virus-induced myocarditis as well as diseases of the central nervous system (CNS) like multiple sclerosis (MS) or epilepsy. The different clinical and pathohistological outcomes after TMEV infection depend on the selected mouse and virus strain as well as the route of infection. In this thesis, a murine model for inducing demyelinating spinal cord (SC) lesions via direct intraspinal (i.s.) TMEV infection was established and used in susceptible as well as resistant mice. The aims of this study were to directly compare the clinical outcome and pathohistological findings with focus on a.) the temporal development of clinical signs as well as b.) inflammatory and degenerative changes within SC and c.) virus spread and establishment of virus persistence as well as the emergence of peripheral nerve (PN) lesions after TMEV infection. The results indicate that i.s. TMEV infection offers the advantage of inducing TMEV-induced demyelinating disease (TMEV-IDD) in susceptible mice after a markedly shortened time span. This enables the investigation of virus-induced SC lesions in a time- and cost-efficient manner. Moreover, the i.s. infection model allows the investigation of TMEV-induced demyelinating SC lesions in resistant B6 mice. Furthermore, the emergence of PN lesions in both strains offers the opportunity to use i.s. TMEV infection as a model for human PN lesions, comparable to those seen in several subtypes of Guillain-Barre syndrome. In conclusion, i.s. TMEV infection of susceptible and resistant mice constitutes a promising model for studying demyelinating disease in both, CNS and peripheral nervous system." @default.
- W3118778885 created "2021-01-18" @default.
- W3118778885 creator A5070685358 @default.
- W3118778885 date "2020-01-01" @default.
- W3118778885 modified "2023-09-23" @default.
- W3118778885 title "Intraspinal Infection with Theiler’s Murine Encephalomyelitis Virus in Resistant and Susceptible Mouse Strains" @default.
- W3118778885 hasPublicationYear "2020" @default.
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