FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118780931> ?p ?o ?g. }

• W3118780931 abstract "Background: Triptolide (TP), a naturally derived compound from Tripterygium wilfordii , has been proven effective in protecting against cardiovascular system, but the molecular mechanisms underlying its protective effects are poorly understood. In the current study, we sought to test the potential protective role of TP in the regulation of vascular calcification in a rat model and explore whether TP attenuates medial vascular calcification by upregulating miRNA-204. Methods: Vitamin D3 plus nicotine (VDN) was used to induce a vascular calcification (VC) model of rat aorta. Von Kossa and Hematoxylin-Eosin staining were applied to assess the degree of calcification of rat aortas. Calcium content and alkaline phosphatase activity were measured. Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was applied to quantify miRNA-204 expression. The localization of runt-related transcription factor-2 (RUNX2) and bone morphogenetic protein-2 (BMP2) expressions were detected by immunohistochemistry and western blotting. Results: Administration of TP greatly reduced vascular calcification in a dose-dependent manner compared with VC controls. The increase in ALP activity and calcium content was ameliorated by TP. Moreover, protein expression levels of BMP2 and RUNX2 were significantly reduced in calcified aortas. MiRNA-204 expression was increased in the TP-treated groups compared with VC controls and the effects of TP were reversed by the intravenous injection of miRNA-204-interfering lentivirus. However, the miRNA-204-overexpressing lentivirus had no additional effects on ALP activity, calcium content, BMP2 and RUNX2 expressions compared with those from TP group. Conclusion: TP inhibited BMP2 and RUNX2 expression and attenuated vascular calcification via upregulating the level of miRNA-204. TP appears to be a potential new therapeutic option for treating vascular calcification." @default.
• W3118780931 created "2021-01-18" @default.
• W3118780931 creator A5018454282 @default.
• W3118780931 creator A5019224827 @default.
• W3118780931 creator A5026205317 @default.
• W3118780931 creator A5028330071 @default.
• W3118780931 creator A5039423055 @default.
• W3118780931 creator A5042365149 @default.
• W3118780931 creator A5070812231 @default.
• W3118780931 creator A5071272252 @default.
• W3118780931 creator A5074144990 @default.
• W3118780931 creator A5079687655 @default.
• W3118780931 creator A5079815478 @default.
• W3118780931 date "2021-01-11" @default.
• W3118780931 modified "2023-10-10" @default.
• W3118780931 title "Triptolide Attenuates Vascular Calcification by Upregulating Expression of miRNA-204" @default.
• W3118780931 cites W1605998570 @default.
• W3118780931 cites W1978209251 @default.
• W3118780931 cites W1994342907 @default.
• W3118780931 cites W2010461414 @default.
• W3118780931 cites W2021193475 @default.
• W3118780931 cites W2023423781 @default.
• W3118780931 cites W2035102417 @default.
• W3118780931 cites W2048158076 @default.
• W3118780931 cites W2057636545 @default.
• W3118780931 cites W2061046080 @default.
• W3118780931 cites W2067619593 @default.
• W3118780931 cites W2071054065 @default.
• W3118780931 cites W2075397447 @default.
• W3118780931 cites W2089381466 @default.
• W3118780931 cites W2108116509 @default.
• W3118780931 cites W2118407487 @default.
• W3118780931 cites W2148413329 @default.
• W3118780931 cites W2150762378 @default.
• W3118780931 cites W2154833555 @default.
• W3118780931 cites W2160745333 @default.
• W3118780931 cites W2166199725 @default.
• W3118780931 cites W2225805422 @default.
• W3118780931 cites W2604210246 @default.
• W3118780931 cites W2768417209 @default.
• W3118780931 cites W2768478624 @default.
• W3118780931 cites W2790481979 @default.
• W3118780931 cites W2791712097 @default.
• W3118780931 cites W2889593798 @default.
• W3118780931 cites W2922795099 @default.
• W3118780931 cites W2939361294 @default.
• W3118780931 cites W2946612387 @default.
• W3118780931 cites W4293247451 @default.
• W3118780931 doi "https://doi.org/10.3389/fphar.2020.581230" @default.
• W3118780931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7883594" @default.
• W3118780931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33597871" @default.
• W3118780931 hasPublicationYear "2021" @default.
• W3118780931 type Work @default.
• W3118780931 sameAs 3118780931 @default.
• W3118780931 citedByCount "3" @default.
• W3118780931 countsByYear W31187809312023 @default.
• W3118780931 crossrefType "journal-article" @default.
• W3118780931 hasAuthorship W3118780931A5018454282 @default.
• W3118780931 hasAuthorship W3118780931A5019224827 @default.
• W3118780931 hasAuthorship W3118780931A5026205317 @default.
• W3118780931 hasAuthorship W3118780931A5028330071 @default.
• W3118780931 hasAuthorship W3118780931A5039423055 @default.
• W3118780931 hasAuthorship W3118780931A5042365149 @default.
• W3118780931 hasAuthorship W3118780931A5070812231 @default.
• W3118780931 hasAuthorship W3118780931A5071272252 @default.
• W3118780931 hasAuthorship W3118780931A5074144990 @default.
• W3118780931 hasAuthorship W3118780931A5079687655 @default.
• W3118780931 hasAuthorship W3118780931A5079815478 @default.
• W3118780931 hasBestOaLocation W31187809311 @default.
• W3118780931 hasConcept C126322002 @default.
• W3118780931 hasConcept C134018914 @default.
• W3118780931 hasConcept C160160445 @default.
• W3118780931 hasConcept C181199279 @default.
• W3118780931 hasConcept C185592680 @default.
• W3118780931 hasConcept C190283241 @default.
• W3118780931 hasConcept C202751555 @default.
• W3118780931 hasConcept C2776363554 @default.
• W3118780931 hasConcept C2780309369 @default.
• W3118780931 hasConcept C2781164371 @default.
• W3118780931 hasConcept C30352789 @default.
• W3118780931 hasConcept C55493867 @default.
• W3118780931 hasConcept C66694092 @default.
• W3118780931 hasConcept C71924100 @default.
• W3118780931 hasConcept C86803240 @default.
• W3118780931 hasConceptScore W3118780931C126322002 @default.
• W3118780931 hasConceptScore W3118780931C134018914 @default.
• W3118780931 hasConceptScore W3118780931C160160445 @default.
• W3118780931 hasConceptScore W3118780931C181199279 @default.
• W3118780931 hasConceptScore W3118780931C185592680 @default.
• W3118780931 hasConceptScore W3118780931C190283241 @default.
• W3118780931 hasConceptScore W3118780931C202751555 @default.
• W3118780931 hasConceptScore W3118780931C2776363554 @default.
• W3118780931 hasConceptScore W3118780931C2780309369 @default.
• W3118780931 hasConceptScore W3118780931C2781164371 @default.
• W3118780931 hasConceptScore W3118780931C30352789 @default.
• W3118780931 hasConceptScore W3118780931C55493867 @default.
• W3118780931 hasConceptScore W3118780931C66694092 @default.
• W3118780931 hasConceptScore W3118780931C71924100 @default.
• W3118780931 hasConceptScore W3118780931C86803240 @default.
• W3118780931 hasLocation W31187809311 @default.

• next