FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118792314> ?p ?o ?g. }

• W3118792314 endingPage "754" @default.
• W3118792314 startingPage "742" @default.
• W3118792314 abstract "We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of risk.We conducted a case-control study nested within a population-based cohort with up to 8 visits of oral swab collection for each subject over an 11-year period in a high-risk area for esophageal cancer in China. The oral microbiome was evaluated with 16S ribosomal RNA (rRNA) gene sequencing in 428 pre-diagnostic oral specimens from 84 cases with esophageal lesions of severe squamous dysplasia and above (SDA) and 168 matched healthy controls. DESeq analysis was performed to identify taxa of differential abundance. Differential oral species together with subject characteristics were evaluated for their potential in predicting SDA risk by constructing conditional logistic regression models.A total of 125 taxa including 37 named species showed significantly different abundance between SDA cases and controls (all P<0.05 & false discovery rate-adjusted Q<0.10). A multivariate logistic model including 11 SDA lesion-related species and family history of esophageal cancer provided an area under the receiver operating characteristic curve (AUC) of 0.89 (95% CI, 0.84-0.93). Cross-validation and sensitivity analysis, excluding cases diagnosed within 1 year of collection of the baseline specimen and their matched controls, or restriction to screen-endoscopic-detected or clinically diagnosed case-control triads, or using only bacterial data measured at the baseline, yielded AUCs>0.84.The oral microbiome may play an etiological and predictive role in esophageal cancer, and it holds promise as a non-invasive early warning biomarker for risk stratification for esophageal cancer screening programs." @default.
• W3118792314 created "2021-01-18" @default.
• W3118792314 creator A5001854734 @default.
• W3118792314 creator A5007422884 @default.
• W3118792314 creator A5018694636 @default.
• W3118792314 creator A5031009696 @default.
• W3118792314 creator A5032689906 @default.
• W3118792314 creator A5033944228 @default.
• W3118792314 creator A5043237595 @default.
• W3118792314 creator A5043254171 @default.
• W3118792314 creator A5049466352 @default.
• W3118792314 creator A5052394970 @default.
• W3118792314 creator A5058479146 @default.
• W3118792314 creator A5059345306 @default.
• W3118792314 creator A5059913318 @default.
• W3118792314 creator A5060002817 @default.
• W3118792314 creator A5062954647 @default.
• W3118792314 creator A5063793551 @default.
• W3118792314 creator A5068564548 @default.
• W3118792314 creator A5070734537 @default.
• W3118792314 creator A5090056004 @default.
• W3118792314 creator A5090942170 @default.
• W3118792314 date "2020-01-01" @default.
• W3118792314 modified "2023-10-05" @default.
• W3118792314 title "Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China: A nested case-control study" @default.
• W3118792314 cites W1557859957 @default.
• W3118792314 cites W1859685733 @default.
• W3118792314 cites W1967071879 @default.
• W3118792314 cites W1971211622 @default.
• W3118792314 cites W1989889539 @default.
• W3118792314 cites W2026551679 @default.
• W3118792314 cites W2060163194 @default.
• W3118792314 cites W2093250796 @default.
• W3118792314 cites W2128122422 @default.
• W3118792314 cites W2154888801 @default.
• W3118792314 cites W2156536854 @default.
• W3118792314 cites W2158457654 @default.
• W3118792314 cites W2165214578 @default.
• W3118792314 cites W2167417749 @default.
• W3118792314 cites W2179438025 @default.
• W3118792314 cites W2194293427 @default.
• W3118792314 cites W2260354739 @default.
• W3118792314 cites W2268632680 @default.
• W3118792314 cites W2273454643 @default.
• W3118792314 cites W2483668820 @default.
• W3118792314 cites W2537571631 @default.
• W3118792314 cites W2595463139 @default.
• W3118792314 cites W2603845179 @default.
• W3118792314 cites W2736267459 @default.
• W3118792314 cites W2740103697 @default.
• W3118792314 cites W2749884966 @default.
• W3118792314 cites W2762906919 @default.
• W3118792314 cites W2771173285 @default.
• W3118792314 cites W2783101416 @default.
• W3118792314 cites W2797413896 @default.
• W3118792314 cites W2801970806 @default.
• W3118792314 cites W2889646458 @default.
• W3118792314 cites W2906334322 @default.
• W3118792314 cites W2945346908 @default.
• W3118792314 cites W2952838603 @default.
• W3118792314 cites W2965379763 @default.
• W3118792314 cites W4211048478 @default.
• W3118792314 doi "https://doi.org/10.21147/j.issn.1000-9604.2020.06.07" @default.
• W3118792314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7797237" @default.
• W3118792314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33446997" @default.
• W3118792314 hasPublicationYear "2020" @default.
• W3118792314 type Work @default.
• W3118792314 sameAs 3118792314 @default.
• W3118792314 citedByCount "13" @default.
• W3118792314 countsByYear W31187923142021 @default.
• W3118792314 countsByYear W31187923142022 @default.
• W3118792314 countsByYear W31187923142023 @default.
• W3118792314 crossrefType "journal-article" @default.
• W3118792314 hasAuthorship W3118792314A5001854734 @default.
• W3118792314 hasAuthorship W3118792314A5007422884 @default.
• W3118792314 hasAuthorship W3118792314A5018694636 @default.
• W3118792314 hasAuthorship W3118792314A5031009696 @default.
• W3118792314 hasAuthorship W3118792314A5032689906 @default.
• W3118792314 hasAuthorship W3118792314A5033944228 @default.
• W3118792314 hasAuthorship W3118792314A5043237595 @default.
• W3118792314 hasAuthorship W3118792314A5043254171 @default.
• W3118792314 hasAuthorship W3118792314A5049466352 @default.
• W3118792314 hasAuthorship W3118792314A5052394970 @default.
• W3118792314 hasAuthorship W3118792314A5058479146 @default.
• W3118792314 hasAuthorship W3118792314A5059345306 @default.
• W3118792314 hasAuthorship W3118792314A5059913318 @default.
• W3118792314 hasAuthorship W3118792314A5060002817 @default.
• W3118792314 hasAuthorship W3118792314A5062954647 @default.
• W3118792314 hasAuthorship W3118792314A5063793551 @default.
• W3118792314 hasAuthorship W3118792314A5068564548 @default.
• W3118792314 hasAuthorship W3118792314A5070734537 @default.
• W3118792314 hasAuthorship W3118792314A5090056004 @default.
• W3118792314 hasAuthorship W3118792314A5090942170 @default.
• W3118792314 hasBestOaLocation W31187923141 @default.
• W3118792314 hasConcept C121608353 @default.
• W3118792314 hasConcept C126322002 @default.
• W3118792314 hasConcept C143121216 @default.
• W3118792314 hasConcept C143998085 @default.

• next