FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118797736> ?p ?o ?g. }

• W3118797736 abstract "Purpose : To investigate the susceptibility of carbapenemase-producing Enterobacterales (CPE) to mecillinam based on the recently updated European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints for uncomplicated Urinary Tract Infection (uUTI). Methods : The challenge collection consisted of 105 molecularly characterized Enterobacterales [ Klebsiella spp. ( N = 49), Escherichia coli ( N = 30), Enterobacter cloacae ( n = 13), Citrobacter freundii ( N = 9), Proteus mirabilis ( N = 3), and Raoultella ornithinolytica ( N = 1)]. Isolates produced OXA-48 ( N = 18), OXA-48-like ( N = 18), VIM ( N = 22), NDM ( N = 22), KPC ( N = 12), IMI ( N = 9), IMP ( N = 6), GES ( N = 1), OXA-58 ( N = 2) or combinations thereof ( N = 5). MICs of carbapenems were determined by agar gradient diffusion (AGD). MICs of mecillinam were assessed by agar dilution (reference method) and compared to disk diffusion (DD) and AGD. Results : Overall 23/105 CPE (21.9%) were susceptible to mecillinam. Susceptibility was observed in E. coli ( N = 12), E. cloacae ( N = 7), and Klebsiella pneumoniae ( N = 4) producing IMI, OXA-48, OXA-48-like, and NDM-1 carbapenemases. MIC 50 for mecillinam in all isolates was 128 mg/L while MIC 50 for meropenem was 8 mg/L. Lower MICs for mecillinam were found in IMI (MIC 50 8 mg/L) and OXA-48-like (MIC 50 16 mg/L) producers. The comparison of the different susceptibility methods showed very major errors of 12.2% with AGD and 8.5% with disk diffusion when compared to the reference method. Conclusion : Mecillinam susceptibility was restricted to isolates producing IMI-, OXA-48-like, and NDM-1 carbapenemases and was documented despite high carbapenem MICs in some isolates. Mecillinam could be a promising oral antimicrobial in uUTI caused by E. coli and E. cloacae isolates carrying IMI- and OXA-48-like carbapenemases; however, susceptibility testing by AGD and disk diffusion remains problematic." @default.
• W3118797736 created "2021-01-18" @default.
• W3118797736 creator A5014174297 @default.
• W3118797736 creator A5037246171 @default.
• W3118797736 creator A5041454251 @default.
• W3118797736 creator A5056590826 @default.
• W3118797736 creator A5066013679 @default.
• W3118797736 date "2021-01-12" @default.
• W3118797736 modified "2023-10-14" @default.
• W3118797736 title "Susceptibility of Clinical Enterobacterales Isolates With Common and Rare Carbapenemases to Mecillinam" @default.
• W3118797736 cites W1838438316 @default.
• W3118797736 cites W1858576343 @default.
• W3118797736 cites W2001543316 @default.
• W3118797736 cites W2042787365 @default.
• W3118797736 cites W2060561490 @default.
• W3118797736 cites W2120750073 @default.
• W3118797736 cites W2121470545 @default.
• W3118797736 cites W2129143216 @default.
• W3118797736 cites W2142232742 @default.
• W3118797736 cites W2155810132 @default.
• W3118797736 cites W2160450972 @default.
• W3118797736 cites W2466231021 @default.
• W3118797736 cites W2559621415 @default.
• W3118797736 cites W2563726319 @default.
• W3118797736 cites W2603934523 @default.
• W3118797736 cites W2607194758 @default.
• W3118797736 cites W2768462908 @default.
• W3118797736 cites W2778650888 @default.
• W3118797736 cites W2805026993 @default.
• W3118797736 cites W2891842241 @default.
• W3118797736 cites W2901374579 @default.
• W3118797736 cites W2922057176 @default.
• W3118797736 cites W2922647599 @default.
• W3118797736 cites W2948530572 @default.
• W3118797736 cites W2956213575 @default.
• W3118797736 cites W2989881887 @default.
• W3118797736 cites W2991332260 @default.
• W3118797736 cites W3089605874 @default.
• W3118797736 cites W4240831450 @default.
• W3118797736 doi "https://doi.org/10.3389/fmicb.2020.627267" @default.
• W3118797736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7835630" @default.
• W3118797736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33510739" @default.
• W3118797736 hasPublicationYear "2021" @default.
• W3118797736 type Work @default.
• W3118797736 sameAs 3118797736 @default.
• W3118797736 citedByCount "10" @default.
• W3118797736 countsByYear W31187977362022 @default.
• W3118797736 countsByYear W31187977362023 @default.
• W3118797736 crossrefType "journal-article" @default.
• W3118797736 hasAuthorship W3118797736A5014174297 @default.
• W3118797736 hasAuthorship W3118797736A5037246171 @default.
• W3118797736 hasAuthorship W3118797736A5041454251 @default.
• W3118797736 hasAuthorship W3118797736A5056590826 @default.
• W3118797736 hasAuthorship W3118797736A5066013679 @default.
• W3118797736 hasBestOaLocation W31187977361 @default.
• W3118797736 hasConcept C104317684 @default.
• W3118797736 hasConcept C176947019 @default.
• W3118797736 hasConcept C2775945818 @default.
• W3118797736 hasConcept C2777058267 @default.
• W3118797736 hasConcept C2777402170 @default.
• W3118797736 hasConcept C2777637488 @default.
• W3118797736 hasConcept C2777894859 @default.
• W3118797736 hasConcept C2778039505 @default.
• W3118797736 hasConcept C2778709256 @default.
• W3118797736 hasConcept C2778910516 @default.
• W3118797736 hasConcept C2778983983 @default.
• W3118797736 hasConcept C2780493024 @default.
• W3118797736 hasConcept C4937899 @default.
• W3118797736 hasConcept C523546767 @default.
• W3118797736 hasConcept C54355233 @default.
• W3118797736 hasConcept C547475151 @default.
• W3118797736 hasConcept C55493867 @default.
• W3118797736 hasConcept C86803240 @default.
• W3118797736 hasConcept C89423630 @default.
• W3118797736 hasConceptScore W3118797736C104317684 @default.
• W3118797736 hasConceptScore W3118797736C176947019 @default.
• W3118797736 hasConceptScore W3118797736C2775945818 @default.
• W3118797736 hasConceptScore W3118797736C2777058267 @default.
• W3118797736 hasConceptScore W3118797736C2777402170 @default.
• W3118797736 hasConceptScore W3118797736C2777637488 @default.
• W3118797736 hasConceptScore W3118797736C2777894859 @default.
• W3118797736 hasConceptScore W3118797736C2778039505 @default.
• W3118797736 hasConceptScore W3118797736C2778709256 @default.
• W3118797736 hasConceptScore W3118797736C2778910516 @default.
• W3118797736 hasConceptScore W3118797736C2778983983 @default.
• W3118797736 hasConceptScore W3118797736C2780493024 @default.
• W3118797736 hasConceptScore W3118797736C4937899 @default.
• W3118797736 hasConceptScore W3118797736C523546767 @default.
• W3118797736 hasConceptScore W3118797736C54355233 @default.
• W3118797736 hasConceptScore W3118797736C547475151 @default.
• W3118797736 hasConceptScore W3118797736C55493867 @default.
• W3118797736 hasConceptScore W3118797736C86803240 @default.
• W3118797736 hasConceptScore W3118797736C89423630 @default.
• W3118797736 hasFunder F4320311052 @default.
• W3118797736 hasFunder F4320324811 @default.
• W3118797736 hasLocation W31187977361 @default.
• W3118797736 hasLocation W31187977362 @default.
• W3118797736 hasOpenAccess W3118797736 @default.
• W3118797736 hasPrimaryLocation W31187977361 @default.
• W3118797736 hasRelatedWork W1972725879 @default.

• next