FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118807574> ?p ?o ?g. }

• W3118807574 endingPage "1377" @default.
• W3118807574 startingPage "1366" @default.
• W3118807574 abstract "Rationale: Choosing the best ventilation strategy for acute respiratory distress syndrome (ARDS) is complex, yet it is highly relevant to clinicians during a respiratory pandemic. Objectives: To compare the effects of low Vt, high Vt, high positive end-expiratory pressure (PEEP), prone ventilation, high-frequency oscillation, and venovenous extracorporeal membrane oxygenation (VV ECMO) on mortality in ARDS. Methods: We performed a network meta-analysis of randomized trials. We applied the Grading of Recommendations Assessment, Development and Evaluation methodology to discern the relative effect of interventions on mortality. Measurements and Main Results: We analyzed 34 trials including 9,085 adults with primarily moderate-to-severe ARDS (median baseline PaO2/FiO2, 118; interquartile range, 110–143). Prone positioning combined with low Vt was the best strategy (risk ratio [RR], 0.74 [95% confidence interval (CI), 0.60–0.92] vs. low Vt; high certainty). VV ECMO was also rated among the best (RR, 0.78 [95% CI, 0.58–1.05] vs. low Vt; RR, 0.66; [95% CI, 0.49–0.88] vs. high Vt) but was rated with lower certainty because VV ECMO was restricted to very severe ARDS (mean baseline PaO2/FiO2<75). High PEEP combined with low Vt was rated intermediately (RR, 0.91 [95% CI, 0.81–1.03] vs. low Vt; low certainty; RR, 0.77 [95% CI, 0.65–0.91] vs. high Vt; moderate certainty). High Vt was rated worst (RR, 1.19 [95% CI, 1.02–1.37] vs. low Vt; moderate certainty), and we found no support for high-frequency oscillation or high Vt with prone ventilation. Conclusions: These findings suggest that combining low Vt with prone ventilation is associated with the greatest reduction in mortality for critically ill adults with moderate-to-severe ARDS." @default.
• W3118807574 created "2021-01-18" @default.
• W3118807574 creator A5005422010 @default.
• W3118807574 creator A5011364849 @default.
• W3118807574 creator A5030817657 @default.
• W3118807574 creator A5031717153 @default.
• W3118807574 creator A5046860959 @default.
• W3118807574 creator A5077525366 @default.
• W3118807574 creator A5082689235 @default.
• W3118807574 date "2021-06-01" @default.
• W3118807574 modified "2023-09-26" @default.
• W3118807574 title "Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe Acute Respiratory Distress Syndrome. A Network Meta-Analysis" @default.
• W3118807574 cites W1608567126 @default.
• W3118807574 cites W1803784511 @default.
• W3118807574 cites W1823772832 @default.
• W3118807574 cites W1964239337 @default.
• W3118807574 cites W1974404062 @default.
• W3118807574 cites W1981680557 @default.
• W3118807574 cites W1989724333 @default.
• W3118807574 cites W1995393294 @default.
• W3118807574 cites W2009478257 @default.
• W3118807574 cites W2009574966 @default.
• W3118807574 cites W2009713463 @default.
• W3118807574 cites W2020821849 @default.
• W3118807574 cites W2031765198 @default.
• W3118807574 cites W2032669171 @default.
• W3118807574 cites W2037593179 @default.
• W3118807574 cites W2040233478 @default.
• W3118807574 cites W2045215663 @default.
• W3118807574 cites W2057139283 @default.
• W3118807574 cites W2069232520 @default.
• W3118807574 cites W2087615666 @default.
• W3118807574 cites W2090132603 @default.
• W3118807574 cites W2091808438 @default.
• W3118807574 cites W2093043874 @default.
• W3118807574 cites W2101299963 @default.
• W3118807574 cites W2104961217 @default.
• W3118807574 cites W2106923828 @default.
• W3118807574 cites W2109346853 @default.
• W3118807574 cites W2109704422 @default.
• W3118807574 cites W2111861407 @default.
• W3118807574 cites W2115626471 @default.
• W3118807574 cites W2116685432 @default.
• W3118807574 cites W2120076396 @default.
• W3118807574 cites W2122731291 @default.
• W3118807574 cites W2122789293 @default.
• W3118807574 cites W2126385340 @default.
• W3118807574 cites W2126930838 @default.
• W3118807574 cites W2128951939 @default.
• W3118807574 cites W2131666904 @default.
• W3118807574 cites W2133531206 @default.
• W3118807574 cites W2134275835 @default.
• W3118807574 cites W2134592673 @default.
• W3118807574 cites W2139350281 @default.
• W3118807574 cites W2141392701 @default.
• W3118807574 cites W2144625636 @default.
• W3118807574 cites W2147279870 @default.
• W3118807574 cites W2161095279 @default.
• W3118807574 cites W2161328469 @default.
• W3118807574 cites W2162001089 @default.
• W3118807574 cites W2163053457 @default.
• W3118807574 cites W2165094816 @default.
• W3118807574 cites W2165852759 @default.
• W3118807574 cites W2286228001 @default.
• W3118807574 cites W2302077120 @default.
• W3118807574 cites W2333411966 @default.
• W3118807574 cites W2333922183 @default.
• W3118807574 cites W2597070792 @default.
• W3118807574 cites W2606304149 @default.
• W3118807574 cites W2610582798 @default.
• W3118807574 cites W2626627673 @default.
• W3118807574 cites W2758688195 @default.
• W3118807574 cites W2766211624 @default.
• W3118807574 cites W2775771164 @default.
• W3118807574 cites W2793513555 @default.
• W3118807574 cites W2803603947 @default.
• W3118807574 cites W2902259954 @default.
• W3118807574 cites W2902560094 @default.
• W3118807574 cites W2911047707 @default.
• W3118807574 cites W2912354430 @default.
• W3118807574 cites W2944755457 @default.
• W3118807574 cites W2965088939 @default.
• W3118807574 cites W2965320936 @default.
• W3118807574 cites W2989533562 @default.
• W3118807574 cites W3013176450 @default.
• W3118807574 cites W3014754749 @default.
• W3118807574 cites W3035437790 @default.
• W3118807574 cites W3080826687 @default.
• W3118807574 cites W3092777721 @default.
• W3118807574 cites W4235968888 @default.
• W3118807574 cites W4239645904 @default.
• W3118807574 doi "https://doi.org/10.1164/rccm.202008-3039oc" @default.
• W3118807574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33406009" @default.
• W3118807574 hasPublicationYear "2021" @default.
• W3118807574 type Work @default.
• W3118807574 sameAs 3118807574 @default.
• W3118807574 citedByCount "44" @default.
• W3118807574 countsByYear W31188075742021 @default.

• next