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- W3118830064 abstract "Triple negative breast cancer (TNBC) remains challenging because of heterogeneous responses to chemotherapy. Incomplete response is associated with a greater risk of metastatic progression. Therefore, treatments that target chemotherapy-resistant TNBC and enhance chemosensitivity would improve outcomes for these high-risk patients. Breast cancer stem cell-like cells (BCSCs) have been proposed to represent a chemotherapy-resistant subpopulation responsible for tumor initiation, progression and metastases. Targeting this population could lead to improved TNBC disease control. Here, we describe a novel multi-kinase inhibitor, 108600, that targets the TNBC BCSC population. 108600 treatment suppresses growth, colony and mammosphere forming capacity of BCSCs and induces G2M arrest and apoptosis of TNBC cells. In vivo, 108600 treatment of mice bearing triple negative tumors results in the induction of apoptosis and overcomes chemotherapy resistance. Finally, treatment with 108600 and chemotherapy suppresses growth of pre-established TNBC metastases, providing additional support for the clinical translation of this agent to clinical trials." @default.
- W3118830064 created "2021-01-18" @default.
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- W3118830064 date "2021-08-03" @default.
- W3118830064 modified "2023-10-06" @default.
- W3118830064 title "Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease" @default.
- W3118830064 cites W1505803934 @default.
- W3118830064 cites W1573213785 @default.
- W3118830064 cites W1792537923 @default.
- W3118830064 cites W1923452435 @default.
- W3118830064 cites W1934086060 @default.
- W3118830064 cites W1966672378 @default.
- W3118830064 cites W1966836247 @default.
- W3118830064 cites W1974441369 @default.
- W3118830064 cites W1974821746 @default.
- W3118830064 cites W1980959445 @default.
- W3118830064 cites W1996165605 @default.
- W3118830064 cites W1999356404 @default.
- W3118830064 cites W2002821487 @default.
- W3118830064 cites W2005894923 @default.
- W3118830064 cites W2006411424 @default.
- W3118830064 cites W2009117004 @default.
- W3118830064 cites W2009141757 @default.
- W3118830064 cites W2010839009 @default.
- W3118830064 cites W2012258557 @default.
- W3118830064 cites W2013787880 @default.
- W3118830064 cites W2015658471 @default.
- W3118830064 cites W2017975901 @default.
- W3118830064 cites W2022609682 @default.
- W3118830064 cites W2023316892 @default.
- W3118830064 cites W2023427658 @default.
- W3118830064 cites W2033473694 @default.
- W3118830064 cites W2040892143 @default.
- W3118830064 cites W2043240543 @default.
- W3118830064 cites W2051882112 @default.
- W3118830064 cites W2052391242 @default.
- W3118830064 cites W2054879402 @default.
- W3118830064 cites W2070244957 @default.
- W3118830064 cites W2073759231 @default.
- W3118830064 cites W2076615711 @default.
- W3118830064 cites W2079348088 @default.
- W3118830064 cites W2081681244 @default.
- W3118830064 cites W2086828029 @default.
- W3118830064 cites W2088938650 @default.
- W3118830064 cites W2102512718 @default.
- W3118830064 cites W2104343339 @default.
- W3118830064 cites W2104452138 @default.
- W3118830064 cites W2106195342 @default.
- W3118830064 cites W2109678171 @default.
- W3118830064 cites W2110164171 @default.
- W3118830064 cites W2111278368 @default.
- W3118830064 cites W2118605519 @default.
- W3118830064 cites W2122796162 @default.
- W3118830064 cites W2125179719 @default.
- W3118830064 cites W2136741851 @default.
- W3118830064 cites W2137724647 @default.
- W3118830064 cites W2143270175 @default.
- W3118830064 cites W2146117608 @default.
- W3118830064 cites W2146672317 @default.
- W3118830064 cites W2147415463 @default.
- W3118830064 cites W2148429670 @default.
- W3118830064 cites W2159352431 @default.
- W3118830064 cites W2161422385 @default.
- W3118830064 cites W2166464943 @default.
- W3118830064 cites W2168086498 @default.
- W3118830064 cites W2168759561 @default.
- W3118830064 cites W2169923596 @default.
- W3118830064 cites W2170105403 @default.
- W3118830064 cites W2170140374 @default.
- W3118830064 cites W2172988438 @default.
- W3118830064 cites W2192016206 @default.
- W3118830064 cites W2273462154 @default.
- W3118830064 cites W2311739996 @default.
- W3118830064 cites W2417776710 @default.
- W3118830064 cites W2506489222 @default.
- W3118830064 cites W2558450893 @default.
- W3118830064 cites W2559931724 @default.
- W3118830064 cites W2586761827 @default.
- W3118830064 cites W2603112157 @default.
- W3118830064 cites W2604777823 @default.
- W3118830064 cites W2606001457 @default.
- W3118830064 cites W2769851446 @default.
- W3118830064 cites W2785427555 @default.
- W3118830064 cites W2888667754 @default.
- W3118830064 cites W2907859211 @default.
- W3118830064 cites W2908516870 @default.
- W3118830064 cites W2911718257 @default.
- W3118830064 cites W2971246083 @default.