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- W3118863670 abstract "Purpose: Retinal pigment epithelial cell autophagy dysfunction, cellular senescence, and the retinal inflammatory response are key pathogenic factors in age-related macular degeneration (AMD), which has been reviewed in our previously work in 2019. This study aims to identify genes collectively involved in these three biological processes and target drugs in AMD. Methods: The pubmed2ensembl database was used to perform text mining. The GeneCodis database was applied to analyze gene ontology biological process and the KEGG pathway. The STRING database was used to analyze protein–protein interaction analysis and hub genes were identified by the Cytoscape software. The Drug Gene Interaction Database was used to perform drug–gene interactions. Results: We identified 62 genes collectively involved in AMD, autophagy, cellular senescence, and inflammatory response, 19 biological processes including 42 genes, 11 enriched KEGG pathways including 37 genes, and 12 hub genes step by step via the above biomedical databases. Finally, five hub genes (IL-6, VEGF-A, TP53, IL-1β, and transforming growth factor [TGF]-β1) and their specific interaction modes were identified, corresponding with 24 target drugs with therapeutic potential for AMD. Conclusions: IL-6, VEGF-A, TP53, IL-1β, and TGF-β1 are pivotal in autophagy, cellular senescence, and the inflammatory response in AMD, corresponding with 24 drugs with therapeutic potential for AMD, providing definite molecular mechanisms for further research and new possibilities for AMD treatment in the future. Translational Relevance: IL-6, VEGF-A, TP53, IL-1β, and TGF-β1 may be new targets for AMD gene therapy and drug development." @default.
- W3118863670 created "2021-01-18" @default.
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- W3118863670 date "2021-01-08" @default.
- W3118863670 modified "2023-10-02" @default.
- W3118863670 title "Common Genes Involved in Autophagy, Cellular Senescence and the Inflammatory Response in AMD and Drug Discovery Identified via Biomedical Databases" @default.
- W3118863670 cites W1964074574 @default.
- W3118863670 cites W1965256208 @default.
- W3118863670 cites W1967809423 @default.
- W3118863670 cites W1975403576 @default.
- W3118863670 cites W1985029869 @default.
- W3118863670 cites W2005002911 @default.
- W3118863670 cites W2009668465 @default.
- W3118863670 cites W2010011258 @default.
- W3118863670 cites W2011186165 @default.
- W3118863670 cites W2021814263 @default.
- W3118863670 cites W2039298589 @default.
- W3118863670 cites W2054389372 @default.
- W3118863670 cites W2065371135 @default.
- W3118863670 cites W2068001921 @default.
- W3118863670 cites W2074817792 @default.
- W3118863670 cites W2075634939 @default.
- W3118863670 cites W2083651366 @default.
- W3118863670 cites W2084575920 @default.
- W3118863670 cites W2092681483 @default.
- W3118863670 cites W2104488717 @default.
- W3118863670 cites W2139655181 @default.
- W3118863670 cites W2140092994 @default.
- W3118863670 cites W2142663409 @default.
- W3118863670 cites W2145642577 @default.
- W3118863670 cites W2154681615 @default.
- W3118863670 cites W2160226180 @default.
- W3118863670 cites W2162229546 @default.
- W3118863670 cites W2278340732 @default.
- W3118863670 cites W2302291950 @default.
- W3118863670 cites W2321127785 @default.
- W3118863670 cites W2325986363 @default.
- W3118863670 cites W2338221729 @default.
- W3118863670 cites W2339120378 @default.
- W3118863670 cites W2546848075 @default.
- W3118863670 cites W2557491692 @default.
- W3118863670 cites W2559175446 @default.
- W3118863670 cites W2575431311 @default.
- W3118863670 cites W2582372140 @default.
- W3118863670 cites W2588082404 @default.
- W3118863670 cites W2594410394 @default.
- W3118863670 cites W2605674430 @default.
- W3118863670 cites W2613238640 @default.
- W3118863670 cites W2751584274 @default.
- W3118863670 cites W2751953166 @default.
- W3118863670 cites W2782896657 @default.
- W3118863670 cites W2789736393 @default.
- W3118863670 cites W2790056846 @default.
- W3118863670 cites W2791096285 @default.
- W3118863670 cites W2792892933 @default.
- W3118863670 cites W2794632709 @default.
- W3118863670 cites W2799372405 @default.
- W3118863670 cites W2802026713 @default.
- W3118863670 cites W2803087035 @default.
- W3118863670 cites W2810193750 @default.
- W3118863670 cites W2885387074 @default.
- W3118863670 cites W2887684755 @default.
- W3118863670 cites W2896973773 @default.
- W3118863670 cites W2897967198 @default.
- W3118863670 cites W2900600199 @default.
- W3118863670 cites W2902429326 @default.
- W3118863670 cites W2944376069 @default.
- W3118863670 cites W2947209693 @default.
- W3118863670 cites W2950753203 @default.
- W3118863670 cites W2963010656 @default.
- W3118863670 cites W2964556340 @default.
- W3118863670 cites W2985994884 @default.
- W3118863670 cites W2997183251 @default.
- W3118863670 cites W2997542977 @default.
- W3118863670 cites W3008912381 @default.
- W3118863670 cites W3012834768 @default.
- W3118863670 cites W4230260250 @default.
- W3118863670 cites W4236854108 @default.
- W3118863670 cites W4238998321 @default.
- W3118863670 cites W4243659532 @default.
- W3118863670 cites W4245571454 @default.
- W3118863670 cites W4245829749 @default.
- W3118863670 cites W4249053481 @default.
- W3118863670 cites W4249695527 @default.
- W3118863670 cites W4253455650 @default.
- W3118863670 cites W4254351544 @default.
- W3118863670 cites W4254722098 @default.
- W3118863670 cites W56085145 @default.