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• W3118885655 abstract "There are conflicting data about localization of poly(ADP-ribose)polymerase-1 and its product poly(ADP-ribose) in mitochondria. To finally clarify the discussion, we investigated with biochemical and cell biological methods the potential presence of poly(ADP-ribose) polymerase-1 in these organelles. Our data show that endogenous and overexpressed poly(ADP-ribose)polymerase 1 is only localized to the nucleus with a clear exclusion of cytosolic compartments. In addition, highly purified mitochondria devoid of nuclear contaminations do not contain poly(ADP-ribose)polymerase-1. Although no poly(ADP-ribose)polymerase-1 enzyme is detectable in mitochondria, a shorter variant of its product poly(ADP-ribose) is present, associated specifically with a small subset of mitochondrial proteins as revealed by immunoprecipitation and protein fingerprint analysis. These proteins are located at key-points of the Krebs-cycle, are chaperones involved in mitochondrial functionality and quality-control, and are RNA-binding proteins important for transcript stability, respectively. Of note, despite the fact that especially poly(ADP-ribose)polymerase-1 is its own major target for modification, we could not detect this enzyme by mass spectrometry in these organelles. These data suggests a new way of targeted nuclear-mitochondrial signaling, mediated by nuclear poly(ADP-ribosyl)ation dependent on poly(ADP-ribose)polymerase-1." @default.
• W3118885655 created "2021-01-18" @default.
• W3118885655 creator A5011789298 @default.
• W3118885655 creator A5021983212 @default.
• W3118885655 creator A5057573463 @default.
• W3118885655 creator A5068077927 @default.
• W3118885655 date "2021-01-08" @default.
• W3118885655 modified "2023-09-26" @default.
• W3118885655 title "Mitochondria are devoid of poly(ADP‐ribose)polymerase‐1, but harbor its product oligo(ADP‐ribose)" @default.
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• W3118885655 doi "https://doi.org/10.1002/jcb.29887" @default.
• W3118885655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33417272" @default.
• W3118885655 hasPublicationYear "2021" @default.
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