Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118907265> ?p ?o ?g. }
- W3118907265 endingPage "0271678X2098150" @default.
- W3118907265 startingPage "0271678X2098150" @default.
- W3118907265 abstract "Preclinical and postmortem studies have suggested that regional synaptic density and glucose consumption (CMRGlc) are strongly related. However, the relation between synaptic density and cerebral glucose metabolism in the human brain has not directly been assessed in vivo. Using [11C]UCB-J binding to synaptic vesicle glycoprotein 2 A (SV2A) as indicator for synaptic density and [18F]FDG for measuring cerebral glucose consumption, we studied twenty healthy female subjects (age 29.6 ± 9.9 yrs) who underwent a single-day dual-tracer protocol (GE Signa PET-MR). Global measures of absolute and relative CMRGlc and specific binding of [11C]UCB-J were indeed highly significantly correlated (r > 0.47, p < 0.001). However, regional differences in relative [18F]FDG and [11C]UCB-J uptake were observed, with up to 19% higher [11C]UCB-J uptake in the medial temporal lobe (MTL) and up to 17% higher glucose metabolism in frontal and motor-related areas and thalamus. This pattern has a considerable overlap with the brain regions showing different levels of aerobic glycolysis. Regionally varying energy demands of inhibitory and excitatory synapses at rest may also contribute to this difference. Being unaffected by astroglial and/or microglial energy demands, changes in synaptic density in the MTL may therefore be more sensitive to early detection of pathological conditions compared to changes in glucose metabolism." @default.
- W3118907265 created "2021-01-18" @default.
- W3118907265 creator A5000110993 @default.
- W3118907265 creator A5006794669 @default.
- W3118907265 creator A5016458045 @default.
- W3118907265 creator A5057591711 @default.
- W3118907265 creator A5066111936 @default.
- W3118907265 creator A5081304921 @default.
- W3118907265 date "2021-01-14" @default.
- W3118907265 modified "2023-09-25" @default.
- W3118907265 title "In vivo synaptic density relates to glucose metabolism at rest in healthy subjects, but is strongly modulated by regional differences" @default.
- W3118907265 cites W1962641016 @default.
- W3118907265 cites W1972203766 @default.
- W3118907265 cites W1983924090 @default.
- W3118907265 cites W1987159390 @default.
- W3118907265 cites W1987888423 @default.
- W3118907265 cites W2008595762 @default.
- W3118907265 cites W2011128631 @default.
- W3118907265 cites W2014888437 @default.
- W3118907265 cites W2025767657 @default.
- W3118907265 cites W2038684428 @default.
- W3118907265 cites W2039701538 @default.
- W3118907265 cites W2042422091 @default.
- W3118907265 cites W2045050476 @default.
- W3118907265 cites W2050577000 @default.
- W3118907265 cites W2052889056 @default.
- W3118907265 cites W2068106324 @default.
- W3118907265 cites W2072833030 @default.
- W3118907265 cites W2074905557 @default.
- W3118907265 cites W2076173615 @default.
- W3118907265 cites W2079598623 @default.
- W3118907265 cites W2083556553 @default.
- W3118907265 cites W2083579475 @default.
- W3118907265 cites W2092635505 @default.
- W3118907265 cites W2100279614 @default.
- W3118907265 cites W2100398092 @default.
- W3118907265 cites W2106931873 @default.
- W3118907265 cites W2113359311 @default.
- W3118907265 cites W2121166660 @default.
- W3118907265 cites W2147270524 @default.
- W3118907265 cites W2155957566 @default.
- W3118907265 cites W2168534058 @default.
- W3118907265 cites W2168937351 @default.
- W3118907265 cites W2170978964 @default.
- W3118907265 cites W2204761283 @default.
- W3118907265 cites W2254886489 @default.
- W3118907265 cites W2273026997 @default.
- W3118907265 cites W2276615166 @default.
- W3118907265 cites W2311377444 @default.
- W3118907265 cites W2503767557 @default.
- W3118907265 cites W2581215498 @default.
- W3118907265 cites W2589217068 @default.
- W3118907265 cites W2614237850 @default.
- W3118907265 cites W2617401930 @default.
- W3118907265 cites W2621969480 @default.
- W3118907265 cites W26851485 @default.
- W3118907265 cites W2742230759 @default.
- W3118907265 cites W2744619973 @default.
- W3118907265 cites W2759050422 @default.
- W3118907265 cites W2883737562 @default.
- W3118907265 cites W2884189849 @default.
- W3118907265 cites W2887203046 @default.
- W3118907265 cites W2911724176 @default.
- W3118907265 cites W2933363539 @default.
- W3118907265 cites W2936898982 @default.
- W3118907265 cites W2950389023 @default.
- W3118907265 cites W2972604459 @default.
- W3118907265 cites W2979263588 @default.
- W3118907265 cites W2991944724 @default.
- W3118907265 cites W2997938254 @default.
- W3118907265 cites W2999688222 @default.
- W3118907265 cites W3002807449 @default.
- W3118907265 cites W3025834426 @default.
- W3118907265 cites W3031195566 @default.
- W3118907265 cites W3037822297 @default.
- W3118907265 cites W391810772 @default.
- W3118907265 doi "https://doi.org/10.1177/0271678x20981502" @default.
- W3118907265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8327121" @default.
- W3118907265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33444094" @default.
- W3118907265 hasPublicationYear "2021" @default.
- W3118907265 type Work @default.
- W3118907265 sameAs 3118907265 @default.
- W3118907265 citedByCount "14" @default.
- W3118907265 countsByYear W31189072652021 @default.
- W3118907265 countsByYear W31189072652022 @default.
- W3118907265 countsByYear W31189072652023 @default.
- W3118907265 crossrefType "journal-article" @default.
- W3118907265 hasAuthorship W3118907265A5000110993 @default.
- W3118907265 hasAuthorship W3118907265A5006794669 @default.
- W3118907265 hasAuthorship W3118907265A5016458045 @default.
- W3118907265 hasAuthorship W3118907265A5057591711 @default.
- W3118907265 hasAuthorship W3118907265A5066111936 @default.
- W3118907265 hasAuthorship W3118907265A5081304921 @default.
- W3118907265 hasBestOaLocation W31189072652 @default.
- W3118907265 hasConcept C112592302 @default.
- W3118907265 hasConcept C126322002 @default.
- W3118907265 hasConcept C130316041 @default.
- W3118907265 hasConcept C134018914 @default.