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• W3118932689 abstract "Circulating tumor cells (CTCs) have been considered as an alternative to tissue biopsy for providing both germline-specific and tumor-derived genetic variations. Single-cell analysis of CTCs enables in-depth investigation of tumor heterogeneity and individualized clinical assessment. However, common CTC enrichment techniques generally have limitations of low throughput and cell damage. Herein, based on micropore-arrayed filtration membrane and microfluidic chip, we established an integrated CTC isolation platform with high-throughput, high-efficiency, and less cell damage. We observed a capture rate of around 85% and a purity of 60.4% by spiking tumor cells (PC-9) into healthy blood samples. Detection of CTCs from lung cancer patients demonstrated a positive detectable rate of 87.5%. Additionally, single CTCs, ctDNA and liver biopsy tissue of a representative advanced lung cancer patient were collected and sequenced, which revealed comprehensive genetic information of CTCs while reflected the differences in genetic profiles between different biological samples. This work provides a promising tool for CTCs isolation and further analysis at single-cell resolution with potential clinical value." @default.
• W3118932689 created "2021-01-18" @default.
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• W3118932689 date "2021-01-02" @default.
• W3118932689 modified "2023-09-27" @default.
• W3118932689 title "Design and Clinical Application of an Integrated Microfluidic Device for Circulating Tumor Cells Isolation and Single-Cell Analysis" @default.
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• W3118932689 doi "https://doi.org/10.3390/mi12010049" @default.
• W3118932689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7824094" @default.
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• W3118932689 hasPublicationYear "2021" @default.
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