FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118938983> ?p ?o ?g. }

• W3118938983 endingPage "974" @default.
• W3118938983 startingPage "958" @default.
• W3118938983 abstract "Abstract Gestational exposure to environmental pollutants can induce oxidative injury and apoptosis since the fetal organs are sensitively vulnerable to these chemicals. In this work, we have investigated the renal anti‐apoptotic efficiency of linseed (LS) against the oxidative stress‐mediated upregulation of the fetal apoptosis‐related genes following the prenatal intoxication with diesel nanoparticles (DNPs) and/or fenitrothion (FNT). A fifty‐six timed‐pregnant rats were equally divided to eight groups; control, LS (20% in diet), DNPs (0.5 mg/kg by intratracheal inoculation), FNT (3.76 mg/kg by gavage), DNPs+FNT, LS + DNPs, LS + FNT, and LS + DNPs+FNT. The transmission electron microscope analysis revealed the spherical shape of diesel particles with a homogeneous nanosized range (20–92.3 nm) and the crystallinity was confirmed by electron diffraction microscopy. Administration of DNPs and/or FNT significantly increased fetal renal malondialdehyde, nitric oxide, and glutathione reductase as compared with the control group. However, they declined the level of glutathione together with the activities of glutathione peroxidase, glutathione‐S‐transferase, superoxide dismutase, and catalase. Furthermore, DNPs and/or FNT elicited many histopathological changes in fetal renal cells, markedly up‐regulated apoptosis‐related gene expressions (p53, p21 caspase‐3, and caspase‐9), and evoked DNA breaks as detected by comet assay. Interestingly, LS supplementation significantly ameliorated the disturbances in oxidant/antioxidant biomarkers, downregulated the apoptosis gene expressions, and alleviated DNA damage alongside renal cell architecture. These findings reveal that the antioxidant and anti‐apoptotic characteristics of LS are acceptable defender pointers for the renal injury especially during gestational exposure to DNPs and/or FNT." @default.
• W3118938983 created "2021-01-18" @default.
• W3118938983 creator A5004717471 @default.
• W3118938983 creator A5024505088 @default.
• W3118938983 creator A5030431043 @default.
• W3118938983 creator A5051669394 @default.
• W3118938983 creator A5090692853 @default.
• W3118938983 date "2021-01-04" @default.
• W3118938983 modified "2023-09-27" @default.
• W3118938983 title "Linseed ameliorates renal apoptosis in rat fetuses induced by single or combined exposure to diesel nanoparticles or fenitrothion by inhibiting transcriptional activation of p21/p53 and caspase‐3/9 through pro‐oxidant stimulus" @default.
• W3118938983 cites W1545899030 @default.
• W3118938983 cites W1575245978 @default.
• W3118938983 cites W1581414347 @default.
• W3118938983 cites W1632725235 @default.
• W3118938983 cites W1768247331 @default.
• W3118938983 cites W1812614540 @default.
• W3118938983 cites W1934565948 @default.
• W3118938983 cites W1966794054 @default.
• W3118938983 cites W1968023303 @default.
• W3118938983 cites W1969148054 @default.
• W3118938983 cites W1978794982 @default.
• W3118938983 cites W1983799581 @default.
• W3118938983 cites W1990244207 @default.
• W3118938983 cites W1991263862 @default.
• W3118938983 cites W1992168438 @default.
• W3118938983 cites W1995272322 @default.
• W3118938983 cites W1996027116 @default.
• W3118938983 cites W1997788169 @default.
• W3118938983 cites W2000072147 @default.
• W3118938983 cites W2002786142 @default.
• W3118938983 cites W2008757142 @default.
• W3118938983 cites W2017470431 @default.
• W3118938983 cites W2023577374 @default.
• W3118938983 cites W2024337476 @default.
• W3118938983 cites W2035333762 @default.
• W3118938983 cites W2044081025 @default.
• W3118938983 cites W2052534784 @default.
• W3118938983 cites W2053670661 @default.
• W3118938983 cites W2055993373 @default.
• W3118938983 cites W2057766916 @default.
• W3118938983 cites W2059278874 @default.
• W3118938983 cites W2059857863 @default.
• W3118938983 cites W2060035882 @default.
• W3118938983 cites W2062669701 @default.
• W3118938983 cites W2062703926 @default.
• W3118938983 cites W2067773266 @default.
• W3118938983 cites W2071240988 @default.
• W3118938983 cites W2073549425 @default.
• W3118938983 cites W2073889150 @default.
• W3118938983 cites W2078730881 @default.
• W3118938983 cites W2080406513 @default.
• W3118938983 cites W2082654436 @default.
• W3118938983 cites W2082902668 @default.
• W3118938983 cites W2088866343 @default.
• W3118938983 cites W2089147128 @default.
• W3118938983 cites W2092629964 @default.
• W3118938983 cites W2094061196 @default.
• W3118938983 cites W2099024183 @default.
• W3118938983 cites W2118603147 @default.
• W3118938983 cites W2121522081 @default.
• W3118938983 cites W2121966499 @default.
• W3118938983 cites W2123545197 @default.
• W3118938983 cites W2130562385 @default.
• W3118938983 cites W2140697633 @default.
• W3118938983 cites W2142078834 @default.
• W3118938983 cites W2153541503 @default.
• W3118938983 cites W2157530259 @default.
• W3118938983 cites W2165178639 @default.
• W3118938983 cites W2165601251 @default.
• W3118938983 cites W2168098741 @default.
• W3118938983 cites W2198191364 @default.
• W3118938983 cites W2267907650 @default.
• W3118938983 cites W2276402733 @default.
• W3118938983 cites W2299921258 @default.
• W3118938983 cites W2342300953 @default.
• W3118938983 cites W2342953619 @default.
• W3118938983 cites W2415799310 @default.
• W3118938983 cites W2553105863 @default.
• W3118938983 cites W2563656879 @default.
• W3118938983 cites W2590937578 @default.
• W3118938983 cites W2616129231 @default.
• W3118938983 cites W2728557398 @default.
• W3118938983 cites W2756041018 @default.
• W3118938983 cites W2761836525 @default.
• W3118938983 cites W2800636988 @default.
• W3118938983 cites W2810572494 @default.
• W3118938983 cites W2883007868 @default.
• W3118938983 cites W2899415029 @default.
• W3118938983 cites W2908925188 @default.
• W3118938983 cites W2947264263 @default.
• W3118938983 cites W2948214942 @default.
• W3118938983 cites W2968190332 @default.
• W3118938983 cites W2969377001 @default.
• W3118938983 cites W3004456739 @default.
• W3118938983 cites W3036912751 @default.
• W3118938983 cites W33317596 @default.
• W3118938983 cites W4255968098 @default.
• W3118938983 cites W4293247451 @default.

• next