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- W3118966532 abstract "Hepatocellular carcinoma (HCC) is a leading cause of mortality worldwide. There is yet no effective therapy available for advanced HCC. A major limitation to develop therapeutic treatments is the lack of accurate in vitro models recapitulating key-features of this disease. Here, we report a co-culture spheroid model combining human hepatic stellate cells and hepatocytes, which are the key cell types involved in HCC development. This model emulates HCC pathological features, such as a collagen-rich fibrotic capsule, acting as a barrier for drug delivery." @default.
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- W3118966532 date "2020-01-01" @default.
- W3118966532 modified "2023-10-14" @default.
- W3118966532 title "Modelling the tumor micro-environment in hepatocellular carcinoma using multi-cellular spheroids" @default.
- W3118966532 hasPublicationYear "2020" @default.
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