FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118979076> ?p ?o ?g. }

• W3118979076 endingPage "14" @default.
• W3118979076 startingPage "1" @default.
• W3118979076 abstract "Lung adenocarcinoma (LUAD), which accounts for 60% of non-small-cell lung cancers, is poorly diagnosed and has a low average 5-year survival rate (approximately 20%). It remains the leading cause of cancer-related deaths worldwide. Studies on long noncoding RNAs (lncRNAs) in LUAD-related competing endogenous RNA (ceRNA) networks are limited. We aimed to identify novel prognostic biomarkers for LUAD using bioinformatic tools and data analysis. We systemically integrated differentially expressed genes and clinically significant modules using weighted correlation network analysis. We performed a functional analysis of the collected candidate genes and explored three LUAD-related genes (VWF, PECAM1, and COL1A1) associated with the overall survival rates of patients with LUAD. Based on Cox proportional hazards analysis of candidate mRNAs and lncRNAs together with differentially expressed microRNAs, we constructed ceRNA networks, obtained 12 lncRNAs in the ceRNA networks, and revealed seven novel lncRNAs AC021016.2, AC079630.1, AC116407.1, AC125807.2, AF131215.5, LINC01936, and RHOXF1-AS1. These lncRNAs were found to be associated with overall survival rates and are suitable for the prediction of prognosis by Kaplan-Meier survival and receiver operating characteristic curve analyses. In particular, three lncRNAs—AF131215.5, AC125807.2, and LINC01936—showed an independent prognostic value of overall survival for patients with LUAD. We evaluated the diagnostic capabilities of seven lncRNAs for patients with LUAD using principal component analysis and the Gene Set Variation Analysis index. lncRNAs and crucial genes could be effectively used for distinguishing LUAD tumors from normal tissues in the Gene Expression Omnibus profile. In particular, AC021016.2 showed a significant prognostic value in the validation dataset. Our findings reveal the significance of exploring lncRNAs in cancer-related ceRNAs using bioinformatic strategies." @default.
• W3118979076 created "2021-01-18" @default.
• W3118979076 creator A5012380108 @default.
• W3118979076 creator A5039413301 @default.
• W3118979076 date "2021-01-14" @default.
• W3118979076 modified "2023-10-16" @default.
• W3118979076 title "Potential Prognostic Biomarkers of Lung Adenocarcinoma Based on Bioinformatic Analysis" @default.
• W3118979076 cites W1953677527 @default.
• W3118979076 cites W1966327575 @default.
• W3118979076 cites W1987012261 @default.
• W3118979076 cites W2146512944 @default.
• W3118979076 cites W2159707944 @default.
• W3118979076 cites W2163149604 @default.
• W3118979076 cites W2168759949 @default.
• W3118979076 cites W2341867436 @default.
• W3118979076 cites W2524314645 @default.
• W3118979076 cites W2593897082 @default.
• W3118979076 cites W2604271042 @default.
• W3118979076 cites W2620140547 @default.
• W3118979076 cites W2754970987 @default.
• W3118979076 cites W2772355432 @default.
• W3118979076 cites W2784160822 @default.
• W3118979076 cites W2786224552 @default.
• W3118979076 cites W2795304569 @default.
• W3118979076 cites W2887396609 @default.
• W3118979076 cites W2888431631 @default.
• W3118979076 cites W2889646458 @default.
• W3118979076 cites W2893086662 @default.
• W3118979076 cites W2898394729 @default.
• W3118979076 cites W2902729254 @default.
• W3118979076 cites W2907397344 @default.
• W3118979076 cites W2907892565 @default.
• W3118979076 cites W2937095305 @default.
• W3118979076 cites W2938035358 @default.
• W3118979076 cites W2944072514 @default.
• W3118979076 cites W2947503144 @default.
• W3118979076 cites W2949324159 @default.
• W3118979076 cites W2981853759 @default.
• W3118979076 cites W2990056696 @default.
• W3118979076 cites W2998562464 @default.
• W3118979076 cites W3006464014 @default.
• W3118979076 cites W3032250132 @default.
• W3118979076 cites W3041116333 @default.
• W3118979076 cites W3048849240 @default.
• W3118979076 cites W3087745653 @default.
• W3118979076 doi "https://doi.org/10.1155/2021/8859996" @default.
• W3118979076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7822677" @default.
• W3118979076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33511215" @default.
• W3118979076 hasPublicationYear "2021" @default.
• W3118979076 type Work @default.
• W3118979076 sameAs 3118979076 @default.
• W3118979076 citedByCount "17" @default.
• W3118979076 countsByYear W31189790762021 @default.
• W3118979076 countsByYear W31189790762022 @default.
• W3118979076 countsByYear W31189790762023 @default.
• W3118979076 crossrefType "journal-article" @default.
• W3118979076 hasAuthorship W3118979076A5012380108 @default.
• W3118979076 hasAuthorship W3118979076A5039413301 @default.
• W3118979076 hasBestOaLocation W31189790761 @default.
• W3118979076 hasConcept C104317684 @default.
• W3118979076 hasConcept C10515644 @default.
• W3118979076 hasConcept C121608353 @default.
• W3118979076 hasConcept C126322002 @default.
• W3118979076 hasConcept C143998085 @default.
• W3118979076 hasConcept C145059251 @default.
• W3118979076 hasConcept C2776256026 @default.
• W3118979076 hasConcept C2781182431 @default.
• W3118979076 hasConcept C50382708 @default.
• W3118979076 hasConcept C54355233 @default.
• W3118979076 hasConcept C60365752 @default.
• W3118979076 hasConcept C60644358 @default.
• W3118979076 hasConcept C62203573 @default.
• W3118979076 hasConcept C67705224 @default.
• W3118979076 hasConcept C70721500 @default.
• W3118979076 hasConcept C71924100 @default.
• W3118979076 hasConcept C86803240 @default.
• W3118979076 hasConceptScore W3118979076C104317684 @default.
• W3118979076 hasConceptScore W3118979076C10515644 @default.
• W3118979076 hasConceptScore W3118979076C121608353 @default.
• W3118979076 hasConceptScore W3118979076C126322002 @default.
• W3118979076 hasConceptScore W3118979076C143998085 @default.
• W3118979076 hasConceptScore W3118979076C145059251 @default.
• W3118979076 hasConceptScore W3118979076C2776256026 @default.
• W3118979076 hasConceptScore W3118979076C2781182431 @default.
• W3118979076 hasConceptScore W3118979076C50382708 @default.
• W3118979076 hasConceptScore W3118979076C54355233 @default.
• W3118979076 hasConceptScore W3118979076C60365752 @default.
• W3118979076 hasConceptScore W3118979076C60644358 @default.
• W3118979076 hasConceptScore W3118979076C62203573 @default.
• W3118979076 hasConceptScore W3118979076C67705224 @default.
• W3118979076 hasConceptScore W3118979076C70721500 @default.
• W3118979076 hasConceptScore W3118979076C71924100 @default.
• W3118979076 hasConceptScore W3118979076C86803240 @default.
• W3118979076 hasLocation W31189790761 @default.
• W3118979076 hasLocation W31189790762 @default.
• W3118979076 hasLocation W31189790763 @default.
• W3118979076 hasOpenAccess W3118979076 @default.
• W3118979076 hasPrimaryLocation W31189790761 @default.

• next