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• W3118980003 abstract "Background Motor symptoms in Parkinson's disease (PD) patients might be related to high-level task-control deficits. We aimed at investigating the dynamics between sensorimotor network and top-down control networks (frontal–parietal, cingulo-opercular, and cerebellar) in PD and at determining the effects of levodopa on the dynamics of these networks. Methods We investigated dynamic functional connectivity (dFC), during resting state functional magnetic resonance imaging, between sensorimotor network and top-down control networks in 36 PD patients (OFF medication, PD-OFF) and 36 healthy volunteers. We further assessed the effect of medication on dFC in18 PD patients who were also scanned ON medication. Results The dFC analyses identified three discrete states: State I (35.68%) characterized by connections between the cerebellum and sensorimotor network, State II (34.17%) with connections between the sensorimotor and frontal–parietal network, and State III (30.15%) with connection between the sensorimotor and cingulo-opercular network. PD patients have significantly fewer occurrences and overall spent less time (shorter dwell time) in State II compared to healthy controls. After levodopa intake, dwell time improved toward normal. The change in dwell time before and after taking levodopa was negatively related to the respective changes in Unified Parkinson's Disease Rating Scale, Part III. PD-OFF showed significantly decreased connectivity between sensorimotor and control networks and increased connectivity within control networks. These changes were partially improved after levodopa intake. Conclusions Dopamine depletion in PD is associated with abnormalities in temporal and spatial properties between cognitive control and sensorimotor network, possibly contributing to clinical deficits. Levodopa partially restores the network function toward the values observed in healthy volunteers. © 2021 International Parkinson and Movement Disorder Society" @default.
• W3118980003 created "2021-01-18" @default.
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• W3118980003 date "2021-01-06" @default.
• W3118980003 modified "2023-10-02" @default.
• W3118980003 title "Dynamics of Top‐Down Control and Motor Networks in Parkinson's Disease" @default.
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• W3118980003 cites W1540982673 @default.
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• W3118980003 cites W1968248619 @default.
• W3118980003 cites W1973542862 @default.
• W3118980003 cites W1976623182 @default.
• W3118980003 cites W1983183519 @default.
• W3118980003 cites W1985408596 @default.
• W3118980003 cites W1992214067 @default.
• W3118980003 cites W1998444969 @default.
• W3118980003 cites W1999718518 @default.
• W3118980003 cites W2001156057 @default.
• W3118980003 cites W2002314838 @default.
• W3118980003 cites W2006883575 @default.
• W3118980003 cites W2011561395 @default.
• W3118980003 cites W2014133325 @default.
• W3118980003 cites W2016521818 @default.
• W3118980003 cites W2016954751 @default.
• W3118980003 cites W2039812529 @default.
• W3118980003 cites W2043977660 @default.
• W3118980003 cites W2048335199 @default.
• W3118980003 cites W2053491932 @default.
• W3118980003 cites W2054417801 @default.
• W3118980003 cites W2056145524 @default.
• W3118980003 cites W2057166223 @default.
• W3118980003 cites W2060563640 @default.
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• W3118980003 cites W2064963539 @default.
• W3118980003 cites W2064996887 @default.
• W3118980003 cites W2078653473 @default.
• W3118980003 cites W2079590167 @default.
• W3118980003 cites W2085101987 @default.
• W3118980003 cites W2085632971 @default.
• W3118980003 cites W2087175814 @default.
• W3118980003 cites W2094134651 @default.
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• W3118980003 cites W2120423211 @default.
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• W3118980003 cites W2126838454 @default.
• W3118980003 cites W2130974692 @default.
• W3118980003 cites W2138790588 @default.
• W3118980003 cites W2140978740 @default.
• W3118980003 cites W2145039080 @default.
• W3118980003 cites W2150104440 @default.
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• W3118980003 cites W2159549823 @default.
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• W3118980003 doi "https://doi.org/10.1002/mds.28461" @default.
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