FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118985871> ?p ?o ?g. }

• W3118985871 endingPage "7" @default.
• W3118985871 startingPage "2" @default.
• W3118985871 abstract "The impressive success of current cancer immunotherapy in some patients but lack of effectiveness in most patients suggests that additional strategies to promote antitumor immunity are needed. How cancer cells die, whether spontaneously or in response to therapeutic intervention, has a profound effect on the type of immune response mobilized. Here, we review research that highlights a previously unappreciated role of gasdermin-mediated inflammatory death (pyroptosis) to promote antitumor immunity and identifies gasdermin E as a tumor suppressor. Immune elimination of tumor cells by natural killer cells and cytotoxic T lymphocytes, which is the final key event in antitumor immunity, was previously thought to be noninflammatory. The research shows that gasdermin expression in tumor cells converts immune cell-mediated killing to inflammatory pyroptosis when cell death-inducing granzymes directly cleave and activate gasdermins. Granzyme B cleaves gasdermin E, and granzyme A cleaves gasdermin B. The data suggest the potential to harness pyroptosis in the tumor to ignite an effective immune response to immunologically cold tumors. Gasdermin expression also augments toxicity of cancer therapy-gasdermin E expression by B-cell leukemias and lymphomas is a root cause of chimeric antigen receptor (CAR) T-cell cytokine storm, and its expression in normal tissues promotes the toxicity of chemotherapeutic drugs. Even though our knowledge about the role of pyroptosis in cancer is growing, there is still a lot to learn-what activates it, how it is regulated, when it is beneficial, and how it can be harnessed therapeutically to improve cancer immunotherapy or reduce therapy-related toxicity." @default.
• W3118985871 created "2021-01-18" @default.
• W3118985871 creator A5003060618 @default.
• W3118985871 creator A5032499056 @default.
• W3118985871 creator A5042973046 @default.
• W3118985871 date "2021-01-01" @default.
• W3118985871 modified "2023-10-12" @default.
• W3118985871 title "Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?" @default.
• W3118985871 cites W1507793297 @default.
• W3118985871 cites W1550660916 @default.
• W3118985871 cites W1864325817 @default.
• W3118985871 cites W1882905539 @default.
• W3118985871 cites W1983254279 @default.
• W3118985871 cites W2035553271 @default.
• W3118985871 cites W2090859543 @default.
• W3118985871 cites W2109265522 @default.
• W3118985871 cites W2118278569 @default.
• W3118985871 cites W2320177900 @default.
• W3118985871 cites W2418806051 @default.
• W3118985871 cites W2461756806 @default.
• W3118985871 cites W2461915818 @default.
• W3118985871 cites W2462773201 @default.
• W3118985871 cites W2517997111 @default.
• W3118985871 cites W2536322725 @default.
• W3118985871 cites W2560541542 @default.
• W3118985871 cites W2564122215 @default.
• W3118985871 cites W2599240318 @default.
• W3118985871 cites W2608687752 @default.
• W3118985871 cites W2750254726 @default.
• W3118985871 cites W2768102094 @default.
• W3118985871 cites W2792307022 @default.
• W3118985871 cites W2810326672 @default.
• W3118985871 cites W2885385214 @default.
• W3118985871 cites W2885788218 @default.
• W3118985871 cites W2888725678 @default.
• W3118985871 cites W2900507152 @default.
• W3118985871 cites W2936083981 @default.
• W3118985871 cites W2945002892 @default.
• W3118985871 cites W2949795425 @default.
• W3118985871 cites W2966261467 @default.
• W3118985871 cites W2976271971 @default.
• W3118985871 cites W2993434511 @default.
• W3118985871 cites W2999534343 @default.
• W3118985871 cites W3003208487 @default.
• W3118985871 cites W3011500848 @default.
• W3118985871 cites W3012485477 @default.
• W3118985871 cites W3016811071 @default.
• W3118985871 cites W3034318868 @default.
• W3118985871 doi "https://doi.org/10.1158/2326-6066.cir-20-0525" @default.
• W3118985871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7789047" @default.
• W3118985871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33397791" @default.
• W3118985871 hasPublicationYear "2021" @default.
• W3118985871 type Work @default.
• W3118985871 sameAs 3118985871 @default.
• W3118985871 citedByCount "57" @default.
• W3118985871 countsByYear W31189858712021 @default.
• W3118985871 countsByYear W31189858712022 @default.
• W3118985871 countsByYear W31189858712023 @default.
• W3118985871 crossrefType "journal-article" @default.
• W3118985871 hasAuthorship W3118985871A5003060618 @default.
• W3118985871 hasAuthorship W3118985871A5032499056 @default.
• W3118985871 hasAuthorship W3118985871A5042973046 @default.
• W3118985871 hasBestOaLocation W31189858711 @default.
• W3118985871 hasConcept C121608353 @default.
• W3118985871 hasConcept C167672396 @default.
• W3118985871 hasConcept C17172800 @default.
• W3118985871 hasConcept C183193105 @default.
• W3118985871 hasConcept C203014093 @default.
• W3118985871 hasConcept C2776062744 @default.
• W3118985871 hasConcept C2776090121 @default.
• W3118985871 hasConcept C2776914184 @default.
• W3118985871 hasConcept C2777209026 @default.
• W3118985871 hasConcept C2777701055 @default.
• W3118985871 hasConcept C2779341262 @default.
• W3118985871 hasConcept C2780380082 @default.
• W3118985871 hasConcept C2780674031 @default.
• W3118985871 hasConcept C502942594 @default.
• W3118985871 hasConcept C54355233 @default.
• W3118985871 hasConcept C71924100 @default.
• W3118985871 hasConcept C86803240 @default.
• W3118985871 hasConcept C8891405 @default.
• W3118985871 hasConceptScore W3118985871C121608353 @default.
• W3118985871 hasConceptScore W3118985871C167672396 @default.
• W3118985871 hasConceptScore W3118985871C17172800 @default.
• W3118985871 hasConceptScore W3118985871C183193105 @default.
• W3118985871 hasConceptScore W3118985871C203014093 @default.
• W3118985871 hasConceptScore W3118985871C2776062744 @default.
• W3118985871 hasConceptScore W3118985871C2776090121 @default.
• W3118985871 hasConceptScore W3118985871C2776914184 @default.
• W3118985871 hasConceptScore W3118985871C2777209026 @default.
• W3118985871 hasConceptScore W3118985871C2777701055 @default.
• W3118985871 hasConceptScore W3118985871C2779341262 @default.
• W3118985871 hasConceptScore W3118985871C2780380082 @default.
• W3118985871 hasConceptScore W3118985871C2780674031 @default.
• W3118985871 hasConceptScore W3118985871C502942594 @default.
• W3118985871 hasConceptScore W3118985871C54355233 @default.
• W3118985871 hasConceptScore W3118985871C71924100 @default.
• W3118985871 hasConceptScore W3118985871C86803240 @default.

• next