Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118992848> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W3118992848 abstract "Abstract Background Autoimmune disease related hemophagocytic syndrome, in other words, macrophage activation syndrome(MAS), is a rare, but lethal complication of autoimmune disease. At present, specific treatment guidelines for adult MAS have not been formulated, most experience are derived from children, researches about etoposide are scarce. As the importance of etoposide in the initial treatment had been proved in other subtypes of hemophagocytic syndrome, the objective of this study is to investigate the effectiveness of etoposide in the treatment of the adult macrophage activation syndrome. Result 74 patients with autoimmune disease related hemophagocytic syndrome were involved in this study, they were divided into two groups based on initial treatment, group 1(n=53): initial therapy did not contain etoposide, group 2(n=21): initial therapy contained etoposide. The overall response rate and complete response rate of group 2 were significantly higher than group 1(ORR 90.5% vs 24.5%, CRR 33.3% vs 3.8%, P<0.05). Patients with different HLH remission states have significantly different prognosis(P<0.001). Conclusion Adopting VP-16 in initial treatment can significantly increase the OR rate and CR rate of adult MAS patients, and the HLH states influenced the prognosis significantly." @default.
- W3118992848 created "2021-01-18" @default.
- W3118992848 creator A5002422411 @default.
- W3118992848 creator A5014171327 @default.
- W3118992848 creator A5057765179 @default.
- W3118992848 creator A5066862370 @default.
- W3118992848 creator A5069739901 @default.
- W3118992848 creator A5070070561 @default.
- W3118992848 creator A5086270619 @default.
- W3118992848 date "2021-01-14" @default.
- W3118992848 modified "2023-10-17" @default.
- W3118992848 title "Etoposide as an Effective Drug for Adult Macrophage Activation Syndrome: A Retrospective Study" @default.
- W3118992848 doi "https://doi.org/10.21203/rs.3.rs-144071/v1" @default.
- W3118992848 hasPublicationYear "2021" @default.
- W3118992848 type Work @default.
- W3118992848 sameAs 3118992848 @default.
- W3118992848 citedByCount "0" @default.
- W3118992848 crossrefType "posted-content" @default.
- W3118992848 hasAuthorship W3118992848A5002422411 @default.
- W3118992848 hasAuthorship W3118992848A5014171327 @default.
- W3118992848 hasAuthorship W3118992848A5057765179 @default.
- W3118992848 hasAuthorship W3118992848A5066862370 @default.
- W3118992848 hasAuthorship W3118992848A5069739901 @default.
- W3118992848 hasAuthorship W3118992848A5070070561 @default.
- W3118992848 hasAuthorship W3118992848A5086270619 @default.
- W3118992848 hasBestOaLocation W31189928481 @default.
- W3118992848 hasConcept C126322002 @default.
- W3118992848 hasConcept C203014093 @default.
- W3118992848 hasConcept C2776694085 @default.
- W3118992848 hasConcept C2778119113 @default.
- W3118992848 hasConcept C2779079688 @default.
- W3118992848 hasConcept C2779134260 @default.
- W3118992848 hasConcept C2779613421 @default.
- W3118992848 hasConcept C2780035454 @default.
- W3118992848 hasConcept C71924100 @default.
- W3118992848 hasConcept C81182388 @default.
- W3118992848 hasConcept C90924648 @default.
- W3118992848 hasConcept C98274493 @default.
- W3118992848 hasConceptScore W3118992848C126322002 @default.
- W3118992848 hasConceptScore W3118992848C203014093 @default.
- W3118992848 hasConceptScore W3118992848C2776694085 @default.
- W3118992848 hasConceptScore W3118992848C2778119113 @default.
- W3118992848 hasConceptScore W3118992848C2779079688 @default.
- W3118992848 hasConceptScore W3118992848C2779134260 @default.
- W3118992848 hasConceptScore W3118992848C2779613421 @default.
- W3118992848 hasConceptScore W3118992848C2780035454 @default.
- W3118992848 hasConceptScore W3118992848C71924100 @default.
- W3118992848 hasConceptScore W3118992848C81182388 @default.
- W3118992848 hasConceptScore W3118992848C90924648 @default.
- W3118992848 hasConceptScore W3118992848C98274493 @default.
- W3118992848 hasLocation W31189928481 @default.
- W3118992848 hasOpenAccess W3118992848 @default.
- W3118992848 hasPrimaryLocation W31189928481 @default.
- W3118992848 hasRelatedWork W2208498818 @default.
- W3118992848 hasRelatedWork W2316604092 @default.
- W3118992848 hasRelatedWork W2335942567 @default.
- W3118992848 hasRelatedWork W2973089074 @default.
- W3118992848 hasRelatedWork W3118992848 @default.
- W3118992848 hasRelatedWork W3130908087 @default.
- W3118992848 hasRelatedWork W3181993135 @default.
- W3118992848 hasRelatedWork W4251454972 @default.
- W3118992848 hasRelatedWork W4283260044 @default.
- W3118992848 hasRelatedWork W4303444608 @default.
- W3118992848 isParatext "false" @default.
- W3118992848 isRetracted "false" @default.
- W3118992848 magId "3118992848" @default.
- W3118992848 workType "article" @default.