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• W3119012938 startingPage "723" @default.
• W3119012938 abstract "Increased apoptotic lymphocytes have been correlated to a high incidence of infection in poorly controlled diabetes. This study aimed to determine whether altered voltage-dependent anion channel (VDAC)-hexokinase (HK) association contributes to the increase in apoptosis. Mouse peripheral blood lymphocytes (PBL) exposed to high glucose (Glc)/palmitic acid (PA) were used as the in vitro model, which was compared with PBL isolated from alloxan-induced diabetic mice (in vivo model). Our results showed a significant increase in apoptosis as indicated by the apoptotic index, caspase-3 activity, mitochondrial membrane potential and ultrastructural study. HK and glucose-6-phosphate dehydrogenase (G6PDH) activities were markedly reduced with a profound increase in glucose-6-phosphate level. Co-immunoprecipitation confirms HK interaction with VDAC, an outer mitochondrial membrane protein. Inhibited glycolytic enzyme, i.e. HK and reduced HK-VDAC interaction in our study could contribute to increased apoptosis in lymphocytes exposed to high Glc/PA. Targeting HK-VDAC interaction may therefore provide therapeutic potential for the treatment of diabetes-associated infection." @default.
• W3119012938 created "2021-01-18" @default.
• W3119012938 creator A5011158817 @default.
• W3119012938 creator A5086088560 @default.
• W3119012938 date "2021-01-12" @default.
• W3119012938 modified "2023-10-18" @default.
• W3119012938 title "Altered VDAC-HK association and apoptosis in mouse peripheral blood lymphocytes exposed to diabetic condition: an <i>in vitro</i> and <i>in vivo</i> study" @default.
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• W3119012938 doi "https://doi.org/10.1080/13813455.2020.1867187" @default.
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